Leases - Additional Information (Details) - USD ($) $ in Thousands	1 Months Ended		3 Months Ended			6 Months Ended
	Jun. 30, 2023	Apr. 30, 2022	Jun. 30, 2024	Mar. 31, 2024	Jun. 30, 2023	Jun. 30, 2024	Jun. 30, 2023	Dec. 31, 2023	Jun. 01, 2023	Apr. 01, 2022
Operating Leased Assets [Line Items]
Existence of option to extend				true
Option to extend, description						Certain leases include one or more options to renew, exercisable at the Company’s sole discretion, with renewal terms that can extend the lease from approximately one year to ten years.
Lease renewal term (in years)										5 years
Lease term										10 years
Right-of-use asset			$ 103,282			$ 103,282		$ 109,793
Present value of operating lease liabilities			110,131			110,131		112,392
Impairment loss of leasehold improvements						1,536
Lease payment over sublease term						10,400
Leases Payments			$ 5,361		$ 3,875	$ 8,957	$ 7,289
Weighted average remaining lease term	8 years 5 months 19 days		7 years 5 months 15 days		8 years 5 months 19 days	7 years 5 months 15 days	8 years 5 months 19 days
Weighted average incremental borrowing rate	13.00%		13.00%		13.00%	13.00%	13.00%
Spring House, PA [Member]
Operating Leased Assets [Line Items]
Right-of-use asset										$ 3,546
Tenant improvement allowance		$ 1,184
Present value of operating lease liabilities										1,210
Leasehold Improvements										$ 2,336
Irvine, CA [Member]
Operating Leased Assets [Line Items]
Lease renewal term (in years)									5 years
Lease term									6 years
Right-of-use asset								1,830
Present value of operating lease liabilities								768
Leasehold Improvements								$ 1,062
Cambridge Massachusetts [Member]
Operating Leased Assets [Line Items]
Impairment loss of leasehold improvements				$ 1,536
Impairment loss				1,731
Impairment loss				3,267
General and Administrative Expenses [Member] | Cambridge Massachusetts [Member]
Operating Leased Assets [Line Items]
Impairment loss				540
Research and Development Expenses [Member] | Cambridge Massachusetts [Member]
Operating Leased Assets [Line Items]
Impairment loss				$ 2,727
Maximum [Member]
Operating Leased Assets [Line Items]
Operating lease, remaining term						9 years
Lease renewal term (in years)			10 years			10 years
Minimum [Member]
Operating Leased Assets [Line Items]
Operating lease, remaining term						1 year
Lease renewal term (in years)			1 year			1 year
Minimum [Member] | Spring House, PA [Member]
Operating Leased Assets [Line Items]
Leases Payments		$ 3,029
Minimum [Member] | Irvine, CA [Member]
Operating Leased Assets [Line Items]
Leases Payments	$ 1,079