Leases - Additional Information (Details) - USD ($) $ in Thousands	1 Months Ended		3 Months Ended
	Jun. 30, 2023	Apr. 30, 2022	Mar. 31, 2024	Mar. 31, 2023	Dec. 31, 2023	Jun. 01, 2023	Apr. 01, 2022
Operating Leased Assets [Line Items]
Existence of option to extend			true
Option to extend, description			Certain leases include one or more options to renew, exercisable at the Company’s sole discretion, with renewal terms that can extend the lease from approximately one year to ten years.
Lease renewal term (in years)							5 years
Lease term							10 years
Right-of-use asset			$ 105,669		$ 109,793
Present value of operating lease liabilities			112,174		112,392
Impairment loss of leasehold improvements			1,536
Lease payment over sublease term			10,400
Leases Payments			$ 3,596	$ 3,413
Weighted average remaining lease term			7 years 8 months 12 days	8 years 8 months 4 days
Weighted average incremental borrowing rate			13.00%	13.00%
Spring House, PA [Member]
Operating Leased Assets [Line Items]
Right-of-use asset							$ 3,546
Tenant improvement allowance		$ 1,184
Present value of operating lease liabilities							1,210
Leasehold Improvements							$ 2,336
Irvine, CA [Member]
Operating Leased Assets [Line Items]
Lease renewal term (in years)						5 years
Lease term						6 years
Right-of-use asset					1,830
Present value of operating lease liabilities					768
Leasehold Improvements					$ 1,062
Cambridge Massachusetts [Member]
Operating Leased Assets [Line Items]
Impairment loss of leasehold improvements			$ 1,536
Impairment loss			1,731
Impairment loss			3,267
General and Administrative Expenses [Member] | Cambridge Massachusetts [Member]
Operating Leased Assets [Line Items]
Impairment loss			540
Research and Development Expenses [Member] | Cambridge Massachusetts [Member]
Operating Leased Assets [Line Items]
Impairment loss			$ 2,727
Maximum [Member]
Operating Leased Assets [Line Items]
Operating lease, remaining term			9 years
Lease renewal term (in years)			10 years
Minimum [Member]
Operating Leased Assets [Line Items]
Operating lease, remaining term			1 year
Lease renewal term (in years)			1 year
Minimum [Member] | Spring House, PA [Member]
Operating Leased Assets [Line Items]
Leases Payments		$ 3,029
Minimum [Member] | Irvine, CA [Member]
Operating Leased Assets [Line Items]
Leases Payments	$ 1,079