Condensed Consolidated Statements of Cash Flows - USD ($) $ in Thousands		6 Months Ended
		Jun. 30, 2023	Jun. 30, 2022
Cash flows from operating activities:
Net income (loss)		$ (24,622)	$ (121,359)
Adjustments to reconcile net income (loss) to net cash provided by (used in) operating activities:
Stock-based compensation expense		20,342	11,827
Depreciation and amortization expense		2,927	3,255
Non-cash operating lease cost		4,247	2,305
Net (accretion) amortization of (discounts) premiums on investments		(236)	547
Amortization of debt issuance costs		337	328
Loss on extinguishment of debt		1,625	0
Change in fair value of warrant liabilities		(132)	0
Collaboration (profit) loss sharing - related party		5,713	(705)
Changes in operating assets and liabilities:
Prepaid expenses and other current and other non-current assets		3,579	(10,145)
Collaboration receivable - related party		(7,559)	0
Inventories		(5,340)	0
Deferred income - related party		2,817
Deferred revenue - related party		(951)	(2,709)
Accounts payable		(3,092)	709
Operating lease liabilities		(577)	(2,130)
Accrued expenses and other current and long-term liabilities (3)	[1]	(9,678)	1,735
Net cash used in operating activities		(10,600)	(116,342)
Cash flows from investing activities:
Purchases of property and equipment		(5,301)	(5,113)
Purchases of investments		(4,426)	(36,138)
Sales and maturities of investments		22,983	77,622
Net cash provided by investing activities		13,256	36,371
Cash flows from financing activities:
Proceeds from exercise of stock options		356	387
Proceeds from issuance of common stock from at the market equity offering		11,730	0
Issuance of common stock under ESPP		1,229	892
Proceeds from issuance of debt, net of issuance costs		103,378	27,606
Repayment of notes payable		(52,860)	(1,907)
Net cash provided by financing activities		63,833	26,978
Net increase (decrease) in cash, cash equivalents, and restricted cash		66,489	(52,993)
Effect of exchange rate changes on cash, cash equivalents, and restricted cash		1	0
Cash, cash equivalents and restricted cash at beginning of period		171,215	188,002
Cash, cash equivalents and restricted cash at end of period		237,705	135,009
Supplemental disclosure of cash flow information:
Cash paid for interest		2,869	1,836
Supplemental disclosure of non-cash investing and financing activities:
Property and equipment purchases included in accounts payable and accrued expenses		943	597
Prepaid rent reclassified to right-of-use assets		2,336	4,962
Lease liability arising from obtaining right-of-use assets		1,210	4,370
Recognition of warrant liabilities		2,100	0
Warrants issued related to Term Loan and recorded as debt discount		$ 2,785	$ 0

[1] Includes related party amounts of ($3,398) and $1,379 at June 30, 2023 and 2022, respectively (see Note 16)