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Related Party Transactions - Additional Information (Detail) - USD ($)
$ / shares in Units, $ in Thousands
1 Months Ended 3 Months Ended 6 Months Ended
Jul. 31, 2022
Jun. 30, 2023
Jun. 30, 2022
Jun. 30, 2023
Jun. 30, 2022
Dec. 31, 2022
Feb. 29, 2016
Related Party Transaction [Line Items]              
Transaction price allocated under collaborative arrangement   $ 31,372   $ 31,372   $ 34,770  
Deferred income - related party   $ 2,817   $ 2,817   $ 0  
Common stock at a purchase price   $ 0.001   $ 0.001   $ 0.001  
Nestle Health Science [Member]              
Related Party Transaction [Line Items]              
Collaboration revenue - related party   $ 620 $ (1,024) $ (197) $ 528    
Deferred revenue   95,738   95,738   $ 94,713 $ 120,000
Payments under agreements with related party   0   0      
Due from related party   0   0   0  
Nestle Health Science [Member] | 2021 License Agreement [Member]              
Related Party Transaction [Line Items]              
Collaboration revenue - related party   125,853 1,413 126,975 2,181    
Deferred revenue   0   0   1,976  
Payments under agreements with related party   0 $ 0 13,419 $ 0    
Due from related party   7,559   7,559   0  
TPC, Inc. [Member] | Research and Development Expenses [Member]              
Related Party Transaction [Line Items]              
Option Payment1   833   833      
Accrued Expenses and Other Liabilities [Member] | Nestle Health Science [Member] | 2021 License Agreement [Member]              
Related Party Transaction [Line Items]              
Transaction price allocated under collaborative arrangement   $ 31,372   $ 31,372   $ 34,770  
Other Noncurrent Assets [Member] | TPC, Inc. [Member]              
Related Party Transaction [Line Items]              
Option Payment1 $ 833