Collaboration Profit and Loss - Additional Information (Detail) - USD ($) $ in Thousands		3 Months Ended		6 Months Ended
	Jul. 01, 2021	Jun. 30, 2023	Jun. 30, 2022	Jun. 30, 2023	Jun. 30, 2022	Dec. 31, 2022	Jul. 21, 2021
Business Acquisition [Line Items]
Transaction price allocated under collaborative arrangement		$ 31,372		$ 31,372		$ 34,770
2021 License Agreement [Member]
Business Acquisition [Line Items]
Collaborative arrangement sharing of pre-launch costs, percentage	50.00%
Topic 808 [Member] | Nestle Health Science [Member] | 2021 License Agreement [Member]
Business Acquisition [Line Items]
Transaction price allocated under collaborative arrangement							$ 35,500
Topic 808 [Member] | Total Liabilities [Member] | Nestle Health Science [Member] | 2021 License Agreement [Member]
Business Acquisition [Line Items]
Transaction price allocated under collaborative arrangement	$ 35,500						$ 35,500
Topic 808 [Member] | Accrued Expenses and Other Current Liabilities [Member] | Nestle Health Science [Member] | 2021 License Agreement [Member]
Business Acquisition [Line Items]
Transaction price allocated under collaborative arrangement		31,372		31,372		$ 34,770
Research and Development Expenses [Member] | Topic 808 [Member] | Nestle Health Science [Member] | 2021 License Agreement [Member]
Business Acquisition [Line Items]
Cost associated with pre-launch activities		645	$ 1,538	1,446	$ 3,173
General and Administrative Expenses [Member] | Topic 808 [Member] | Nestle Health Science [Member] | 2021 License Agreement [Member]
Business Acquisition [Line Items]
Cost associated with pre-launch activities		$ 1,539	$ 2,176	$ 4,242	$ 4,614