Nature of the Business and Basis of Presentation - Additional Information (Detail) - USD ($)	1 Months Ended	3 Months Ended				6 Months Ended
	May 31, 2023	Jun. 30, 2023	Mar. 31, 2023	Jun. 30, 2022	Mar. 31, 2022	Jun. 30, 2023	Jun. 30, 2022	Dec. 31, 2022
Nature Of Business And Basis Of Presentation [Line Items]
Entity incorporated month and year						2010-10
Entity incorporation, state or country code						DE
Accumulated deficit		$ 889,133,000				$ 889,133,000		$ 864,511,000
Cash and cash equivalents		229,520,000				229,520,000		$ 163,030,000
Net operating cash outflows						(10,600,000)	$ (116,342,000)
Net Income (Loss)		46,552,000	$ (71,174,000)	$ (64,735,000)	$ (56,624,000)	(24,622,000)	$ (121,359,000)
Twenty Twenty One License Agreement [Member]
Nature Of Business And Basis Of Presentation [Line Items]
Milestones payments received	$ 125,000,000	$ 125,000,000				$ 125,000,000