Nature of the Business and Basis of Presentation - Additional Information (Detail) - USD ($) $ / shares in Units, $ in Thousands			3 Months Ended
	Apr. 27, 2023	Apr. 26, 2023	Mar. 31, 2023	Mar. 31, 2022	Dec. 31, 2022
Nature Of Business And Basis Of Presentation [Line Items]
Entity incorporated month and year			2010-10
Entity incorporation, state or country code			DE
Accumulated deficit			$ 935,685		$ 864,511
Net operating cash outflows			(76,584)	$ (66,445)
Net Income (Loss) Attributable to Parent			$ (71,174)	$ (56,624)
Common stock issued			126,592,604		125,222,273
Common stock at a purchase price			$ 0.001		$ 0.001
Subsequent Event [Member] | Twenty Twenty One License Agreement [Member]
Nature Of Business And Basis Of Presentation [Line Items]
MilestonesPayments		$ 125,000
Subsequent Event [Member] | Term Loan Facility [Member] | Oaktree Fund Administration, LLC [Member]
Nature Of Business And Basis Of Presentation [Line Items]
Credit facility, aggregate principal amount	$ 250,000
Tranche A-1 [Member] | Subsequent Event [Member] | Term Loan Facility [Member] | Oaktree Fund Administration, LLC [Member]
Nature Of Business And Basis Of Presentation [Line Items]
Credit facility, aggregate principal amount	80,000
Tranche A-2 [Member] | Subsequent Event [Member] | Term Loan Facility [Member] | Oaktree Fund Administration, LLC [Member]
Nature Of Business And Basis Of Presentation [Line Items]
Credit facility, aggregate principal amount	30,000
Tranche A Loan [Member] | Subsequent Event [Member] | Term Loan Facility [Member] | Oaktree Fund Administration, LLC [Member]
Nature Of Business And Basis Of Presentation [Line Items]
Credit facility, aggregate principal amount	110,000
Tranche A Loan [Member] | Subsequent Event [Member] | Term Loan Facility [Member] | Hercules Capital Inc [Member]
Nature Of Business And Basis Of Presentation [Line Items]
Repayments of existing credit facility	$ 53,380
Nestle Health Science [Member]
Nature Of Business And Basis Of Presentation [Line Items]
Payment due and payable			$ 125,000