Income Taxes - Schedule of Net Deferred Tax Assets (Detail) - USD ($) $ in Thousands	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Deferred tax assets:
Net operating loss carryforwards	$ 132,560	$ 108,189
Research and development tax credit carryforwards	48,854	53,133
Section 174 capitalized research and development expenses	38,894	0
Stock-based compensation expense	20,048	16,045
Lease Liability	29,717	6,635
Deferred revenue	29,922	36,666
Accrued expenses	4,044	2,475
Section 163(j) limitation	2,303	1,368
Depreciation and amortization	396	247
Other	200	274
Total deferred tax assets	306,938	225,032
Deferred tax liabilities:
Depreciation and amortization	0	0
Right of use assets	(29,568)	(4,918)
Total deferred tax liabilities	(29,568)	(4,918)
Valuation allowance	(277,370)	(220,114)	$ (193,736)	$ (157,346)
Net deferred tax assets	$ 0	$ 0