Income Taxes - Additional Information (Detail) - USD ($)	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Income Tax Disclosure [Line Items]
Income tax benefit	$ 0	$ 0	$ 0
Capitalized research and development costs	160,586,000
Unrecognized tax benefits	$ 0	$ 0	$ 0	$ 0
Massachusetts [Member]
Income Tax Disclosure [Line Items]
Net operating loss carry forwards, expiration year, start	2035
Future Tax Years [Member] | Maximum [Member]
Income Tax Disclosure [Line Items]
Taxable income on NOL	80.00%
Federal [Member]
Income Tax Disclosure [Line Items]
Net operating loss carryforwards	$ 501,789,000
Research and development performance period	5 years
Federal [Member] | Before 2018 [Member]
Income Tax Disclosure [Line Items]
Net operating loss carryforwards	$ 119,800,000
Net operating loss carry forwards, expiration year, start	2035
Federal [Member] | After 2017 [Member]
Income Tax Disclosure [Line Items]
Net operating loss carryforwards	$ 381,989,000
Federal [Member] | Research and Development Tax Credit [Member]
Income Tax Disclosure [Line Items]
Tax credit carryforwards	$ 50,248,000
Tax credit carryforwards, expiration year, start	2031
Federal [Member] | Orphan Drug Credit Carryforwards [Member]
Income Tax Disclosure [Line Items]
Tax credit carryforwards	$ 25,623,000
Foreign [Member]
Income Tax Disclosure [Line Items]
Research and development performance period	15 years
State [Member]
Income Tax Disclosure [Line Items]
Net operating loss carryforwards	$ 481,862,000
State [Member] | Research and Development Tax Credit [Member]
Income Tax Disclosure [Line Items]
Tax credit carryforwards	$ 12,925,000
Tax credit carryforwards, expiration year, start	2028