Leases - Additional Information (Details) - USD ($)	1 Months Ended					12 Months Ended
	Dec. 31, 2022	Apr. 30, 2022	Sep. 30, 2021	Aug. 31, 2021	Jul. 31, 2021	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020	Dec. 01, 2022	Apr. 01, 2022	Sep. 01, 2021	Aug. 01, 2021	Jul. 01, 2021
Operating Leased Assets [Line Items]
Existence of option to extend						true
Option to extend, description						Certain leases include one or more options to renew, exercisable at the Company’s sole discretion, with renewal terms that can extend the lease from approximately one year to five years.
Lease renewal term (in years)										5 years	7 years
Lease term										10 years	10 years		10 years
Right-of-use asset	$ 110,984,000					$ 110,984,000	$ 18,208,000				$ 56,065,000		$ 5,900,000
Tenant improvement allowance		$ 1,223,000			$ 770,000
Present value of operating lease liabilities	111,543,000					111,543,000	24,568,000				54,206,000		2,327,000
Leasehold Improvements											$ 1,859,000		$ 3,573,000
Leases Payments						7,809,000	$ 6,821,000	$ 6,302,000
Asset retirement obligation	$ 452,000					$ 452,000
Weighted average remaining lease term	8 years 11 months 1 day					8 years 11 months 1 day	6 years 1 month 13 days
Weighted average incremental borrowing rate	13.00%					13.00%	10.00%
October 2021 [Member]
Operating Leased Assets [Line Items]
Right-of-use asset												$ 7,602,000
March 2022 [Member]
Operating Leased Assets [Line Items]
Right-of-use asset												2,662,000
Lease Amendment [Member]
Operating Leased Assets [Line Items]
Right-of-use asset									$ 32,837,000
Present value of operating lease liabilities									$ 32,837,000
Spring House, PA
Operating Leased Assets [Line Items]
Right-of-use asset	$ 0					$ 0
Present value of operating lease liabilities	$ 0					$ 0
Office Space [Member]
Operating Leased Assets [Line Items]
Present value of operating lease liabilities												7,602,000
Laboratory Space [Member]
Operating Leased Assets [Line Items]
Tenant improvement allowance				$ 767,000
Present value of operating lease liabilities												1,273,000
Leasehold Improvements												$ 1,389,000
Office and Laboratory Space [Member]
Operating Leased Assets [Line Items]
Lease term												10 years
Maximum [Member]
Operating Leased Assets [Line Items]
Operating lease, remaining term						10 years
Lease renewal term (in years)	5 years					5 years
Minimum [Member]
Operating Leased Assets [Line Items]
Operating lease, remaining term						2 years
Lease renewal term (in years)	1 year					1 year
Leases Payments		$ 2,980,000	$ 101,548,000		$ 4,052,000
Minimum [Member] | October 2021 [Member]
Operating Leased Assets [Line Items]
Leases Payments				12,125,000
Minimum [Member] | March 2022 [Member]
Operating Leased Assets [Line Items]
Leases Payments				$ 2,449,000
Minimum [Member] | Lease Amendment [Member]
Operating Leased Assets [Line Items]
Tenant improvement allowance	$ 1,000,000
Leases Payments	$ 60,022,000