3.22.2 html 216 280 1 true 64 0 false 5 false false R1.htm 100000 - Document - Document and Entity Information Sheet http://serestherapeutics.com/20220630/taxonomy/role/Role_DocumentDocumentAndEntityInformation Document and Entity Information Cover 1 false false R2.htm 100010 - Statement - Condensed Consolidated Balance Sheets Sheet http://serestherapeutics.com/20220630/taxonomy/role/Role_StatementCondensedConsolidatedBalanceSheets Condensed Consolidated Balance Sheets Statements 2 false false R3.htm 100040 - Statement - Condensed Consolidated Balance Sheets (Parenthetical) Sheet http://serestherapeutics.com/20220630/taxonomy/role/Role_StatementCondensedConsolidatedBalanceSheetsParenthetical Condensed Consolidated Balance Sheets (Parenthetical) Statements 3 false false R4.htm 100050 - Statement - Condensed Consolidated Statements of Operations and Comprehensive Income (Loss) Sheet http://serestherapeutics.com/20220630/taxonomy/role/StatementCondensedConsolidatedStatementsOfOperationsAndComprehensiveIncomeLoss Condensed Consolidated Statements of Operations and Comprehensive Income (Loss) Statements 4 false false R5.htm 100070 - Statement - Condensed Consolidated Statement of Stockholders' Equity (Deficit) Sheet http://serestherapeutics.com/20220630/taxonomy/role/Role_StatementCondensedConsolidatedStatementOfStockholdersEquityDeficit Condensed Consolidated Statement of Stockholders' Equity (Deficit) Statements 5 false false R6.htm 100080 - Statement - Condensed Consolidated Statements of Cash Flows Sheet http://serestherapeutics.com/20220630/taxonomy/role/Role_StatementCondensedConsolidatedStatementsOfCashFlows Condensed Consolidated Statements of Cash Flows Statements 6 false false R7.htm 100090 - Statement - Condensed Consolidated Statements of Cash Flows (Parenthetical) Sheet http://serestherapeutics.com/20220630/taxonomy/role/StatementCondensedConsolidatedStatementsOfCashFlowsParenthetical Condensed Consolidated Statements of Cash Flows (Parenthetical) Statements 7 false false R8.htm 100100 - Disclosure - Nature of the Business and Basis of Presentation Sheet http://serestherapeutics.com/20220630/taxonomy/role/Role_DisclosureNatureOfBusinessAndBasisOfPresentation Nature of the Business and Basis of Presentation Notes 8 false false R9.htm 100110 - Disclosure - Summary of Significant Accounting Policies Sheet http://serestherapeutics.com/20220630/taxonomy/role/Role_DisclosureSummaryOfSignificantAccountingPolicies Summary of Significant Accounting Policies Notes 9 false false R10.htm 100120 - Disclosure - Fair Value Measurements Sheet http://serestherapeutics.com/20220630/taxonomy/role/Role_DisclosureFairValueMeasurements Fair Value Measurements Notes 10 false false R11.htm 100130 - Disclosure - Investments Sheet http://serestherapeutics.com/20220630/taxonomy/role/Role_DisclosureInvestments Investments Notes 11 false false R12.htm 100140 - Disclosure - Property and Equipment, Net Sheet http://serestherapeutics.com/20220630/taxonomy/role/Role_DisclosurePropertyAndEquipmentNet Property and Equipment, Net Notes 12 false false R13.htm 100150 - Disclosure - Accrued Expenses and Other Current Liabilities Sheet http://serestherapeutics.com/20220630/taxonomy/role/Role_DisclosureAccruedExpensesAndOtherCurrentLiabilities Accrued Expenses and Other Current Liabilities Notes 13 false false R14.htm 100160 - Disclosure - Leases Sheet http://serestherapeutics.com/20220630/taxonomy/role/DisclosureLeases Leases Notes 14 false false R15.htm 100170 - Disclosure - Note Payable Sheet http://serestherapeutics.com/20220630/taxonomy/role/Role_DisclosureNotePayable Note Payable Notes 15 false false R16.htm 100180 - Disclosure - Common Stock and Stock-Based Awards Sheet http://serestherapeutics.com/20220630/taxonomy/role/Role_DisclosureCommonStockAndStockBasedAwards Common Stock and Stock-Based Awards Notes 16 false false R17.htm 100190 - Disclosure - Net Income (Loss) per Share Sheet http://serestherapeutics.com/20220630/taxonomy/role/DisclosureNetIncomeLossPerShare Net Income (Loss) per Share Notes 17 false false R18.htm 100200 - Disclosure - Collaboration Revenue Sheet http://serestherapeutics.com/20220630/taxonomy/role/Role_DisclosureCollaborationRevenue Collaboration Revenue Notes 18 false false R19.htm 100210 - Disclosure - Commitments and Contingencies Sheet http://serestherapeutics.com/20220630/taxonomy/role/Role_DisclosureCommitmentsAndContingencies Commitments and Contingencies Notes 19 false false R20.htm 100220 - Disclosure - Income Taxes Sheet http://serestherapeutics.com/20220630/taxonomy/role/Role_DisclosureIncomeTaxes Income Taxes Notes 20 false false R21.htm 100230 - Disclosure - Related Party Transactions Sheet http://serestherapeutics.com/20220630/taxonomy/role/Role_DisclosureRelatedPartyTransactions Related Party Transactions Notes 21 false false R22.htm 100250 - Disclosure - Summary of Significant Accounting Policies (Policies) Sheet http://serestherapeutics.com/20220630/taxonomy/role/Role_DisclosureSummaryOfSignificantAccountingPoliciesPolicies Summary of Significant Accounting Policies (Policies) Policies http://serestherapeutics.com/20220630/taxonomy/role/Role_DisclosureSummaryOfSignificantAccountingPolicies 22 false false R23.htm 100260 - Disclosure - Summary of Significant Accounting Policies (Tables) Sheet http://serestherapeutics.com/20220630/taxonomy/role/Role_DisclosureSummaryOfSignificantAccountingPoliciesTables Summary of Significant Accounting Policies (Tables) Tables http://serestherapeutics.com/20220630/taxonomy/role/Role_DisclosureSummaryOfSignificantAccountingPolicies 23 false false R24.htm 100270 - Disclosure - Fair Value Measurements (Tables) Sheet http://serestherapeutics.com/20220630/taxonomy/role/Role_DisclosureFairValueMeasurementsTables Fair Value Measurements (Tables) Tables http://serestherapeutics.com/20220630/taxonomy/role/Role_DisclosureFairValueMeasurements 24 false false R25.htm 100280 - Disclosure - Investments (Tables) Sheet http://serestherapeutics.com/20220630/taxonomy/role/Role_DisclosureInvestmentsTables Investments (Tables) Tables http://serestherapeutics.com/20220630/taxonomy/role/Role_DisclosureInvestments 25 false false R26.htm 100290 - Disclosure - Property and Equipment, Net (Tables) Sheet http://serestherapeutics.com/20220630/taxonomy/role/Role_DisclosurePropertyAndEquipmentNetTables Property and Equipment, Net (Tables) Tables http://serestherapeutics.com/20220630/taxonomy/role/Role_DisclosurePropertyAndEquipmentNet 26 false false R27.htm 100300 - Disclosure - Accrued Expenses and Other Current Liabilities (Tables) Sheet http://serestherapeutics.com/20220630/taxonomy/role/Role_DisclosureAccruedExpensesAndOtherCurrentLiabilitiesTables Accrued Expenses and Other Current Liabilities (Tables) Tables http://serestherapeutics.com/20220630/taxonomy/role/Role_DisclosureAccruedExpensesAndOtherCurrentLiabilities 27 false false R28.htm 100310 - Disclosure - Leases (Tables) Sheet http://serestherapeutics.com/20220630/taxonomy/role/DisclosureLeasesTables Leases (Tables) Tables http://serestherapeutics.com/20220630/taxonomy/role/DisclosureLeases 28 false false R29.htm 100320 - Disclosure - Note Payable (Tables) Sheet http://serestherapeutics.com/20220630/taxonomy/role/Role_DisclosureNotePayableTables Note Payable (Tables) Tables http://serestherapeutics.com/20220630/taxonomy/role/Role_DisclosureNotePayable 29 false false R30.htm 100330 - Disclosure - Common Stock and Stock-Based Awards (Tables) Sheet http://serestherapeutics.com/20220630/taxonomy/role/Role_DisclosureCommonStockAndStockBasedAwardsTables Common Stock and Stock-Based Awards (Tables) Tables http://serestherapeutics.com/20220630/taxonomy/role/Role_DisclosureCommonStockAndStockBasedAwards 30 false false R31.htm 100340 - Disclosure - Net Income (Loss) per Share (Tables) Sheet http://serestherapeutics.com/20220630/taxonomy/role/DisclosureNetIncomeLossPerShareTables Net Income (Loss) per Share (Tables) Tables http://serestherapeutics.com/20220630/taxonomy/role/DisclosureNetIncomeLossPerShare 31 false false R32.htm 100350 - Disclosure - Collaboration Revenue (Tables) Sheet http://serestherapeutics.com/20220630/taxonomy/role/Role_DisclosureCollaborationRevenueTables Collaboration Revenue (Tables) Tables http://serestherapeutics.com/20220630/taxonomy/role/Role_DisclosureCollaborationRevenue 32 false false R33.htm 100360 - Disclosure - Nature of the Business and Basis of Presentation - Additional Information (Detail) Sheet http://serestherapeutics.com/20220630/taxonomy/role/Role_DisclosureNatureOfBusinessAndBasisOfPresentationAdditionalInformationDetail Nature of the Business and Basis of Presentation - Additional Information (Detail) Details 33 false false R34.htm 100370 - Disclosure - Summary of Significant Accounting Policies - Additional Information (Detail) Sheet http://serestherapeutics.com/20220630/taxonomy/role/DisclosureSummaryOfSignificantAccountingPoliciesAdditionalInformationDetail Summary of Significant Accounting Policies - Additional Information (Detail) Details 34 false false R35.htm 100380 - Disclosure - Summary of Significant Accounting Policies - Cash, Cash Equivalents and Restricted Cash (Details) Sheet http://serestherapeutics.com/20220630/taxonomy/role/DisclosureSummaryOfSignificantAccountingPoliciesCashCashEquivalentsAndRestrictedCashDetails Summary of Significant Accounting Policies - Cash, Cash Equivalents and Restricted Cash (Details) Details 35 false false R36.htm 100390 - Disclosure - Fair Value Measurements - Summary of Fair Value Hierarchy for Assets and Liabilities Measured at Fair Value on Recurring Basis (Detail) Sheet http://serestherapeutics.com/20220630/taxonomy/role/Role_DisclosureFairValueMeasurementsSummaryOfFairValueHierarchyForAssetsAndLiabilitiesMeasuredAtFairValueOnRecurringBasisDetail Fair Value Measurements - Summary of Fair Value Hierarchy for Assets and Liabilities Measured at Fair Value on Recurring Basis (Detail) Details 36 false false R37.htm 100400 - Disclosure - Fair Value Measurements - Additional Information (Detail) Sheet http://serestherapeutics.com/20220630/taxonomy/role/Role_DisclosureFairValueMeasurementsAdditionalInformationDetail Fair Value Measurements - Additional Information (Detail) Details 37 false false R38.htm 100410 - Disclosure - Investments - Schedule of Investments by Security Type (Detail) Sheet http://serestherapeutics.com/20220630/taxonomy/role/Role_DisclosureInvestmentsScheduleOfInvestmentsBySecurityTypeDetail Investments - Schedule of Investments by Security Type (Detail) Details 38 false false R39.htm 100420 - Disclosure - Investments - Additional Information (Detail) Sheet http://serestherapeutics.com/20220630/taxonomy/role/Role_DisclosureInvestmentsAdditionalInformationDetail Investments - Additional Information (Detail) Details 39 false false R40.htm 100430 - Disclosure - Investments - Schedule of Amortized Cost and Fair Value of Investments by Contractual Maturity (Detail) Sheet http://serestherapeutics.com/20220630/taxonomy/role/Role_DisclosureInvestmentsScheduleOfAmortizedCostAndFairValueOfInvestmentsByContractualMaturityDetail Investments - Schedule of Amortized Cost and Fair Value of Investments by Contractual Maturity (Detail) Details 40 false false R41.htm 100440 - Disclosure - Property and Equipment, Net - Schedule of Property and Equipment, Net (Detail) Sheet http://serestherapeutics.com/20220630/taxonomy/role/Role_DisclosurePropertyAndEquipmentNetScheduleOfPropertyAndEquipmentNetDetail Property and Equipment, Net - Schedule of Property and Equipment, Net (Detail) Details 41 false false R42.htm 100450 - Disclosure - Property and Equipment, Net - Additional Information (Detail) Sheet http://serestherapeutics.com/20220630/taxonomy/role/Role_DisclosurePropertyAndEquipmentNetAdditionalInformationDetail Property and Equipment, Net - Additional Information (Detail) Details 42 false false R43.htm 100460 - Disclosure - Accrued Expenses and Other Current Liabilities - Summary of Accrued Expenses and Other Current Liabilities (Detail) Sheet http://serestherapeutics.com/20220630/taxonomy/role/Role_DisclosureAccruedExpensesAndOtherCurrentLiabilitiesSummaryOfAccruedExpensesAndOtherCurrentLiabilitiesDetail Accrued Expenses and Other Current Liabilities - Summary of Accrued Expenses and Other Current Liabilities (Detail) Details 43 false false R44.htm 100470 - Disclosure - Leases - Additional Information (Details) Sheet http://serestherapeutics.com/20220630/taxonomy/role/DisclosureLeasesAdditionalInformationDetails Leases - Additional Information (Details) Details 44 false false R45.htm 100480 - Disclosure - Leases - Summary of Operating Lease Assets and Liabilities (Details) Sheet http://serestherapeutics.com/20220630/taxonomy/role/DisclosureLeasesSummaryOfOperatingLeaseAssetsAndLiabilitiesDetails Leases - Summary of Operating Lease Assets and Liabilities (Details) Details 45 false false R46.htm 100490 - Disclosure - Leases - Summary of Lease Costs (Details) Sheet http://serestherapeutics.com/20220630/taxonomy/role/DisclosureLeasesSummaryOfLeaseCostsDetails Leases - Summary of Lease Costs (Details) Details 46 false false R47.htm 100500 - Disclosure - Leases - Schedule of Future Payments of Operating Lease Liabilities (Details) Sheet http://serestherapeutics.com/20220630/taxonomy/role/DisclosureLeasesScheduleOfFuturePaymentsOfOperatingLeaseLiabilitiesDetails Leases - Schedule of Future Payments of Operating Lease Liabilities (Details) Details 47 false false R48.htm 100510 - Disclosure - Note Payable - Additional Information (Detail) Sheet http://serestherapeutics.com/20220630/taxonomy/role/Role_DisclosureNotePayableAdditionalInformationDetail Note Payable - Additional Information (Detail) Details 48 false false R49.htm 100520 - Disclosure - Note Payable - Summary of Future Principal Payments Due Under Arrangement, Excluding Interest and End of Term Charge (Detail) Sheet http://serestherapeutics.com/20220630/taxonomy/role/Role_DisclosureNotePayableSummaryOfFuturePrincipalPaymentsDueUnderArrangementExcludingInterestAndEndOfTermChargeDetail Note Payable - Summary of Future Principal Payments Due Under Arrangement, Excluding Interest and End of Term Charge (Detail) Details 49 false false R50.htm 100530 - Disclosure - Common Stock and Stock-Based Awards - Additional Information (Details) Sheet http://serestherapeutics.com/20220630/taxonomy/role/DisclosureCommonStockAndStockbasedAwardsAdditionalInformationDetails Common Stock and Stock-Based Awards - Additional Information (Details) Details 50 false false R51.htm 100540 - Disclosure - Common Stock and Stock-Based Awards - Summary of Stock Option Activity (Detail) Sheet http://serestherapeutics.com/20220630/taxonomy/role/DisclosureCommonStockAndStockbasedAwardsSummaryOfStockOptionActivityDetail Common Stock and Stock-Based Awards - Summary of Stock Option Activity (Detail) Details 51 false false R52.htm 100550 - Disclosure - Common Stock and Stock-Based Awards - Stock Options - Additional Information (Detail) Sheet http://serestherapeutics.com/20220630/taxonomy/role/Role_DisclosureCommonStockAndStockBasedAwardsStockOptionsAdditionalInformationDetail Common Stock and Stock-Based Awards - Stock Options - Additional Information (Detail) Details 52 false false R53.htm 100560 - Disclosure - Common Stock and Stock-Based Awards - Summary of Restricted Stock Unit Activity (Detail) Sheet http://serestherapeutics.com/20220630/taxonomy/role/DisclosureCommonStockAndStockbasedAwardsSummaryOfRestrictedStockUnitActivityDetail Common Stock and Stock-Based Awards - Summary of Restricted Stock Unit Activity (Detail) Details 53 false false R54.htm 100570 - Disclosure - Common Stock and Stock-Based Awards - Restricted Stock Units - Additional Information (Detail) Sheet http://serestherapeutics.com/20220630/taxonomy/role/DisclosureCommonStockAndStockbasedAwardsRestrictedStockUnitsAdditionalInformationDetail Common Stock and Stock-Based Awards - Restricted Stock Units - Additional Information (Detail) Details 54 false false R55.htm 100580 - Disclosure - Common Stock and Stock-Based Awards - Summary of Stock Based Compensation Expense (Detail) Sheet http://serestherapeutics.com/20220630/taxonomy/role/Role_DisclosureCommonStockAndStockBasedAwardsSummaryOfStockBasedCompensationExpenseDetail Common Stock and Stock-Based Awards - Summary of Stock Based Compensation Expense (Detail) Details 55 false false R56.htm 100590 - Disclosure - Net Income (Loss) per Share - Basic and Diluted Net Income (Loss) per Share Attributable to Common Stockholders (Detail) Sheet http://serestherapeutics.com/20220630/taxonomy/role/DisclosureNetIncomeLossPerShareBasicAndDilutedNetIncomeLossPerShareAttributableToCommonStockholdersDetail Net Income (Loss) per Share - Basic and Diluted Net Income (Loss) per Share Attributable to Common Stockholders (Detail) Details http://serestherapeutics.com/20220630/taxonomy/role/DisclosureNetIncomeLossPerShareTables 56 false false R57.htm 100600 - Disclosure - Collaboration Revenue - Additional Information (Detail) Sheet http://serestherapeutics.com/20220630/taxonomy/role/Role_DisclosureCollaborationRevenueAdditionalInformationDetail Collaboration Revenue - Additional Information (Detail) Details 57 false false R58.htm 100610 - Disclosure - Collaboration Revenue - Changes in Contract Liabilities (Detail) Sheet http://serestherapeutics.com/20220630/taxonomy/role/Role_DisclosureCollaborationRevenueChangesInContractLiabilitiesDetail Collaboration Revenue - Changes in Contract Liabilities (Detail) Details 58 false false R59.htm 100620 - Disclosure - Collaboration Revenue - Schedule of Revenue Recognized (Detail) Sheet http://serestherapeutics.com/20220630/taxonomy/role/Role_DisclosureCollaborationRevenueScheduleOfRevenueRecognizedDetail Collaboration Revenue - Schedule of Revenue Recognized (Detail) Details 59 false false R60.htm 100630 - Disclosure - Commitments and Contingencies - Additional Information (Detail) Sheet http://serestherapeutics.com/20220630/taxonomy/role/Role_DisclosureCommitmentsAndContingenciesAdditionalInformationDetail Commitments and Contingencies - Additional Information (Detail) Details 60 false false R61.htm 100640 - Disclosure - Income Taxes - Additional Information (Detail) Sheet http://serestherapeutics.com/20220630/taxonomy/role/Role_DisclosureIncomeTaxesAdditionalInformationDetail Income Taxes - Additional Information (Detail) Details 61 false false R62.htm 100650 - Disclosure - Related Party Transactions - Additional Information (Detail) Sheet http://serestherapeutics.com/20220630/taxonomy/role/Role_DisclosureRelatedPartyTransactionsAdditionalInformationDetail Related Party Transactions - Additional Information (Detail) Details 62 false false All Reports Book All Reports mcrb-20220630.htm mcrb-20220630.xsd mcrb-20220630_cal.xml mcrb-20220630_def.xml mcrb-20220630_lab.xml mcrb-20220630_pre.xml mcrb-ex10_1.htm mcrb-ex31_1.htm mcrb-ex31_2.htm mcrb-ex32_1.htm mcrb-ex32_2.htm http://fasb.org/us-gaap/2022 http://xbrl.sec.gov/dei/2022 true true