Nature of the Business and Basis of Presentation - Additional Information (Detail) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2022	Mar. 31, 2021	Dec. 31, 2021
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Entity incorporated month and year	2010-10
Entity incorporation, state or country code	DE
Accumulated deficit	$ 670,978		$ 614,354
Net Income (Loss) Attributable to Parent	(56,624)	$ (35,465)
Cash, cash equivalents and short and long-term investments	$ 248,001