Income Taxes - Schedule of Net Deferred Tax Assets (Detail) - USD ($) $ in Thousands	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019	Dec. 31, 2018
Deferred tax assets:
Net operating loss carryforwards	$ 108,189	$ 106,351
Research and development tax credit carryforwards	53,133	42,311
Capitalized organization costs	181	214
Stock-based compensation expense	16,045	11,615
Lease Liability	6,635	4,283
Charitable Contributions	50	15
Deferred Revenue	36,666	29,553
Accrued expenses	2,475	1,783
Capitalized research and development expenses	43	51
Section 163(j) limitation	1,368	540
Depreciation and amortization	247
Total deferred tax assets	225,032	196,716
Deferred tax liabilities:
Depreciation and amortization		(510)
Right of use assets	(4,918)	(2,470)
Total deferred tax liabilities	(4,918)	(2,980)
Valuation allowance	$ (220,114)	$ (193,736)	$ (157,346)	$ (132,009)