Summary of Significant Accounting Policies - Additional Information (Detail) - USD ($)	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019	Dec. 31, 2018
Accounting Policies [Line Items]
Maximum maturity days for cash equivalents	90 days
Restricted investments	$ 1,401,000	$ 1,400,000
Restricted cash	8,000,000	0
Impairment losses on long lived assets	0
Adoption of new revenue standard (ASC 606)	(131,507,000)	(174,750,000)	$ 48,324,000	$ 48,045,000
Accounts receivable	0	1,186,000
Unbilled accounts receivable	0	$ 8,201,000
Revenue related to sales-based royalties	$ 0
Minimum percentage of likelihood of tax benefit being realized upon settlement	50.00%
ASU 2018-18 [Member]
Accounting Policies [Line Items]
Change in accounting principle, accounting standards update, adopted	true
Change in accounting principle, accounting standards update, adoption date	Jan. 01, 2020
Change in accounting principle, accounting standards update, immaterial effect	true
ASU 2018-13 [Member]
Accounting Policies [Line Items]
Change in accounting principle, accounting standards update, adopted	true
Change in accounting principle, accounting standards update, adoption date	Jan. 01, 2020
Change in accounting principle, accounting standards update, immaterial effect	true
Laboratory Equipment [Member]
Accounting Policies [Line Items]
Useful life of asset	5 years
Furniture and Office Equipment [Member]
Accounting Policies [Line Items]
Useful life of asset	3 years