X0202 SCHEDULE 13G 0001009268 XXXXXXXX LIVE Common Stock, $0.001 par value per share 06/25/2026 0001609550 Inspire Medical Systems, Inc. 457730109 5500 Wayzata Blvd., Suite 1600, Golden Valley MN 55416 Rule 13d-1(c) D. E. Shaw & Co., L.P. DE 0.00 1374263.00 0.00 1483107.00 1483107.00 N 5.1 IA PN David E. Shaw X1 0.00 1374263.00 0.00 1483107.00 1483107.00 N 5.1 IN Inspire Medical Systems, Inc. 5500 Wayzata Blvd., Suite 1600, Golden Valley, MN 55416 D. E. Shaw & Co., L.P. David E. Shaw The business address for each reporting person is: Two Manhattan West 375 Ninth Avenue, 52nd Floor New York, NY 10001 D. E. Shaw & Co., L.P. is a limited partnership organized under the laws of the state of Delaware. David E. Shaw is a citizen of the United States of America. Y D. E. Shaw & Co., L.P.: 1,483,107 shares This is composed of (i) 486,655 shares in the name of D. E. Shaw Valence Portfolios, L.L.C., (ii) 362,550 shares in the name of D. E. Shaw Oculus Portfolios, L.L.C., (iii) 31,529 shares in the name of D. E. Shaw Composite Portfolios, L.L.C., and (iv) 602,373 shares under the management of D. E. Shaw Investment Management, L.L.C. David E. Shaw: 1,483,107 shares This is composed of (i) 486,655 shares in the name of D. E. Shaw Valence Portfolios, L.L.C., (ii) 362,550 shares in the name of D. E. Shaw Oculus Portfolios, L.L.C., (iii) 31,529 shares in the name of D. E. Shaw Composite Portfolios, L.L.C., and (iv) 602,373 shares under the management of D. E. Shaw Investment Management, L.L.C. David E. Shaw does not own any shares directly. By virtue of David E. Shaw's position as President and sole shareholder of D. E. Shaw & Co., Inc., which is the general partner of D. E. Shaw & Co., L.P., which in turn is the investment adviser of D. E. Shaw Valence Portfolios, L.L.C., D. E. Shaw Oculus Portfolios, L.L.C., and D. E. Shaw Composite Portfolios, L.L.C. and the managing member of D. E. Shaw Investment Management, L.L.C., and by virtue of David E. Shaw's position as President and sole shareholder of D. E. Shaw & Co. II, Inc., which is the managing member of D. E. Shaw & Co., L.L.C., which in turn is the manager of D. E. Shaw Valence Portfolios, L.L.C., D. E. Shaw Oculus Portfolios, L.L.C., and D. E. Shaw Composite Portfolios, L.L.C., David E. Shaw may be deemed to have the shared power to vote or direct the vote of 1,374,263 shares and the shared power to dispose or direct the disposition of 1,483,107 shares, the 1,483,107 shares as described above constituting 5.1% of the outstanding shares, and, therefore, David E. Shaw may be deemed to be the beneficial owner of such shares. David E. Shaw disclaims beneficial ownership of such 1,483,107 shares. D. E. Shaw & Co., L.P.: 5.1% David E. Shaw: 5.1% D. E. Shaw & Co., L.P.: 0 shares David E. Shaw: 0 shares D. E. Shaw & Co., L.P.: 1,374,263 shares David E. Shaw: 1,374,263 shares D. E. Shaw & Co., L.P.: 0 shares David E. Shaw: 0 shares D. E. Shaw & Co., L.P.: 1,483,107 shares David E. Shaw: 1,483,107 shares Y Y Y Y Y N By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under § 240.14a-11. Exhibit 2: Joint Filing Agreement, by and among the Reporting Persons, dated July 2, 2026. D. E. Shaw & Co., L.P. /s/ Daniel R. Marcus 07/02/2026 David E. Shaw /s/ Daniel R. Marcus 07/02/2026 Exhibit 1: Power of Attorney, granted by David E. Shaw relating to D. E. Shaw & Co., Inc., in favor of the signatories hereto, among others, dated August 1, 2024.