X0306 4 2020-11-03 0 0001609550 Inspire Medical Systems, Inc. INSP 0001199894 NELSON MARILYN C C/O INSPIRE MEDICAL SYSTEMS, INC. 5500 WAYZATA BLVD., SUITE 1600 GOLDEN VALLEY MN 55416 1 0 0 0 Common Stock 2020-11-03 4 S 0 7000 144.65 D 138017 I See Footnote Common Stock 3189 D The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $144.30 to $145.00. The Reporting Person undertakes to provide Inspire Medical Systems, Inc. (the "Company"), any security holder of the Company, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. Shares held by GDN Holdings, LLC, of which the Reporting Person is the managing member. /s/ Richard Buchholz, as Attorney-in-Fact for Marilyn Carlson Nelson 2020-11-05