X0306 4 2020-09-09 0 0001609550 Inspire Medical Systems, Inc. INSP 0001737127 Ban Randy C/O INSPIRE MEDICAL SYSTEMS, INC. 5500 WAYZATA BLVD., SUITE 1600 GOLDEN VALLEY MN 55416 0 1 0 0 Chief Commercial Officer Common Stock 2020-09-09 4 M 0 30000 1.14 A 30189 D Common Stock 2020-09-09 4 S 0 24808 117.03 D 5381 D Common Stock 2020-09-09 4 S 0 5192 119.99 D 189 D Common Stock 167 I By son Common Stock 166 I By daughter Stock Option (Right to Buy) 1.14 2020-09-09 4 M 0 30000 0 D 2023-09-12 Common Stock 30000 15187 D Includes 47 additional shares acquired under the Inspire Medical Systems, Inc. (the "Company") 2018 Employee Stock Purchase Plan since the Reporting Person's ownership report filed on April 10, 2020. The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $117.00 to $117.83. The reporting person undertakes to provide the Company, any security holder of the Company, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. The option is fully vested and exercisable. /s/ Richard Buchholz, as Attorney-in-Fact for Randy Ban 2020-09-11