X0306 4 2020-10-09 0 0001609550 Inspire Medical Systems, Inc. INSP 0001609405 Khuong Chau Quang C/O INSPIRE MEDICAL SYSTEMS, INC. 5500 WAYZATA BLVD., SUITE 1600 GOLDEN VALLEY MN 55416 1 0 0 0 Common Stock 2020-10-09 4 A 0 91 130 A 1875 D Represents shares of common stock received in lieu of cash fees pursuant to the Issuer's Non-Employee Director Compensation Policy. Pursuant to an agreement with OrbiMed Advisors LLC ("Advisors") and OrbiMed Capital GP V LLC ("GP V"), the Reporting Person is obligated to transfer these securities, or the economic benefit thereof, to Advisors and GP V, which will in turn ensure that such securities or economic benefits are provided to OrbiMed Private Investments V, LP ("OPI V"). /s/ Richard Buchholz, Attorney-in-Fact for Chau Q. Khuong 2020-10-13