SEC Form 3

FORM 3

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person* La Barge Joseph (Last) (First) (Middle) 3737 MARKET STREET SUITE 1300 (Street) PHILADELPHIA PA 19104 (City) (State) (Zip)	2. Date of Event Requiring Statement (Month/Day/Year) 05/02/2016	3. Issuer Name and Ticker or Trading Symbol Spark Therapeutics, Inc. [ ONCE ]
		4. Relationship of Reporting Person(s) to Issuer (Check all applicable) Director 10% Owner X Officer (give title below) Other (specify below) See remarks	5. If Amendment, Date of Original Filed (Month/Day/Year)
			6. Individual or Joint/Group Filing (Check Applicable Line) X Form filed by One Reporting Person Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Beneficially Owned
1. Title of Security (Instr. 4)	2. Amount of Securities Beneficially Owned (Instr. 4)	3. Ownership Form: Direct (D) or Indirect (I) (Instr. 5)	4. Nature of Indirect Beneficial Ownership (Instr. 5)
Common Stock	5,325(1)(2)	D
Common Stock	200	I	Held by Reporting Person's immediate family members

Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 4)	2. Date Exercisable and Expiration Date (Month/Day/Year)		3. Title and Amount of Securities Underlying Derivative Security (Instr. 4)		4. Conversion or Exercise Price of Derivative Security	5. Ownership Form: Direct (D) or Indirect (I) (Instr. 5)	6. Nature of Indirect Beneficial Ownership (Instr. 5)
	Date Exercisable	Expiration Date	Title	Amount or Number of Shares
Employee Stock Option (right to buy)	(3)	06/09/2024	Common Stock	25,383	$3.45	D
Employee Stock Option (right to buy)	(4)	07/01/2024	Common Stock	31,929	$3.45	D
Employee Stock Option (right to buy)	(5)	03/15/2025	Common Stock	45,000	$68.45	D
Employee Stock Option (right to buy)	(6)	01/04/2026	Common Stock	45,000	$40.44	D

Explanation of Responses:

1. 4,825 shares were granted on December 11, 2013 and 25% vested on December 11, 2014 and the remainder vests in equal quarterly installments over the following three years.

2. 500 shares were granted on November 4, 2015 and vest upon a performance condition

3. 25% vested November 11, 2014 and the remainder vests in equal quarterly installments over the following three years.

4. 25% vested May 24, 2015 and the remainder vests in equal quarterly installments over the following three years.

5. 25% vested March 16, 2016 and the remainder vests in equal quarterly installments over the following three years.

6. 25% vested January 5, 2017 and the remainder vests in equal quarterly installments over the following three years.

Remarks:

General Counsel and Head of Business Administration

	/s/ Joseph W. La Barge	05/04/2016
	** Signature of Reporting Person	Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 5 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
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