X0306 4 2019-12-17 1 0001609351 Spark Therapeutics, Inc. ONCE 0001590102 Mehra Anand SOFINNOVA INVESTMENTS, INC. 3000 SAND HILL ROAD, 4-250 MENLO PARK CA 94025 1 0 0 0 Common Stock 2019-12-17 4 U 0 40203 114.50 D 0 D Common Stock 2019-12-17 4 U 0 481270 114.50 D 0 I See Footnote Stock Option (Right to Buy) 81.53 2019-12-17 4 D 0 4000 0.00 D 2028-05-29 Common Stock 4000 0 D Stock Option (Right to Buy) 50.93 2019-12-17 4 D 0 4000 0.00 D 2027-05-30 Common Stock 4000 0 D Stock Option (Right to Buy) 56.22 2019-12-17 4 D 0 6000 0.00 D 2026-05-31 Common Stock 6000 0 D Disposed of pursuant to the Agreement and Plan of Merger, dated February 22, 2019, by and between Spark Therapeutics, Inc. ("Spark"), Roche Holdings, Inc. ("Roche") and 022019 Merger Subsidiary, Inc. ("Merger Sub") (the "Merger Agreement" and the transactions contemplated thereby, the "Merger"), whereby Roche caused Merger Sub to conduct a tender offer for all of the issued and outstanding shares of common stock, par value $0.001 per share, of Spark, at a price of $114.50 per share. On December 17, 2019, Merger Sub irrevocably accepted for payment all shares that were validly tendered and not withdrawn. Pursuant to the terms of the Merger Agreement, immediately prior to the effective time of the Merger, each outstanding Spark stock option, whether vested or unvested, was converted into the right to an amount in cash (less applicable tax withholdings) equal to the product of (a) the excess of $114.50 over the per share exercise price of such stock option and (b) the total number of shares of common stock subject to such stock option. The securities are owned directly by Sofinnova Venture Partners VIII, L.P. ("SVP VIII"). Sofinnova Management VIII, L.L.C. ("SM VIII"), the general partner of SVP VIII, and Anand Mehra, a director of the Issuer, James I. Healy, and Michael Powell, the managing members of SM VIII, may be deemed to have shared voting and dispositive power over the shares owned by SVP VIII. Such persons and entities disclaim beneficial ownership over the shares owned by SVP VIII except to the extent of any pecuniary interest therein. /s/ Joseph W. La Barge, Attorney-in-Fact 2019-12-17