UNITED STATES SECURITIES AND EXCHANGE COMMISSION

Washington, DC 20549

FORM N-Q

QUARTERLY SCHEDULE OF PORTFOLIO HOLDINGS OF REGISTERED MANAGEMENT INVESTMENT COMPANY

Investment Company Act file number 811-22971

Nuveen NASDAQ 100 Dynamic Overwrite Fund

(Exact name of registrant as specified in charter)

    333 West Wacker Drive, Chicago, Illinois 60606    

(Address of principal executive offices) (Zip code)

Gifford R. Zimmerman—Vice President and Secretary

    333 West Wacker Drive, Chicago, Illinois 60606    

(Name and address of agent for service)

Registrant’s telephone number, including area code:     312-917-7700    

Date of fiscal year end:       December 31      

Date of reporting period:  March 31, 2018  

Form N-Q is to be used by management investment companies, other than small business investment companies registered on Form N-5 (§§ 239.24 and 274.5 of this chapter), to file reports with the Commission, not later than 60 days after the close of the first and third fiscal quarters, pursuant to rule 30b1-5 under the Investment Company Act of 1940 (17 CFR 270.30b1-5). The Commission may use the information provided on Form N-Q in its regulatory, disclosure review, inspection, and policymaking roles.

A registrant is required to disclose the information specified by Form N-Q, and the Commission will make this information public. A registrant is not required to respond to the collection of information contained in Form N-Q unless the Form displays a currently valid Office of Management and Budget (“OMB”) control number. Please direct comments concerning the accuracy of the information collection burden estimate and any suggestions for reducing the burden to the Secretary, Securities and Exchange Commission, 450 Fifth Street, NW, Washington, DC 20549-0609. The OMB has reviewed this collection of information under the clearance requirements of 44 U.S.C. § 3507.

Item 1. Schedule of Investments

QQQX	Nuveen NASDAQ 100 Dynamic Overwrite Fund Portfolio of Investments    March 31, 2018
	(Unaudited)

Shares		Description (1)	Value
		LONG-TERM INVESTMENTS – 101.9%
		COMMON STOCKS – 100.0%
		Air Freight & Logistics – 0.1%
	2,768	FedEx Corporation	$	664,624
		Airlines – 0.5%
	31,000	Delta Air Lines, Inc.		1,699,110
	6,742	Ryanair Holdings PLC, Sponsored ADR		828,255
	26,300	Southwest Airlines Co.		1,506,464
		Total Airlines		4,033,829
		Auto Components – 0.2%
	26,602	American Axle and Manufacturing Holdings Inc.		404,882
	21,986	Gentex Corporation		506,118
	4,227	Lear Corporation		786,602
		Total Auto Components		1,697,602
		Automobiles – 0.8%
	49,165	Ford Motor Company		544,748
	23,900	Tesla Inc., (2)		6,360,507
		Total Automobiles		6,905,255
		Banks – 0.1%
	5,000	JP Morgan Chase & Co.		549,850
		Beverages – 0.7%
	11,117	Brown-Forman Corporation, Class B		604,765
	91,000	Monster Beverage Corporation, (2)		5,206,110
		Total Beverages		5,810,875
		Biotechnology – 7.9%
	10,000	AbbVie Inc.		946,500
	8,300	Agios Pharmaceutical Inc., (2)		678,774
	14,052	Alkermes PLC, (2)		814,454
	114,700	Amgen Inc.		19,554,056
	28,366	Biogen Inc., (2)		7,767,178
	125,700	Celgene Corporation, (2), (3)		11,213,697
	206,900	Gilead Sciences, Inc., (3)		15,598,191
	61,949	Immunogen, Inc., (2)		651,703
	10,536	Ionis Pharmaceuticals, Inc., (2)		464,427
	12,904	Myriad Genetics Inc., (2)		381,313
	17,600	Regeneron Pharmaceuticals, Inc., (2)		6,060,736
	12,177	Seattle Genetics, Inc., (2)		637,344
	3,617	United Therapeutics Corporation, (2)		406,406
		Total Biotechnology		65,174,779
		Capital Markets – 0.6%
	5,000	CBOE Holdings Inc.		570,500
	9,902	Moody’s Corporation		1,597,193
	24,475	Morgan Stanley		1,320,671
	11,627	SEI Investments Company		870,979
	5,883	T. Rowe Price Group Inc.		635,188
		Total Capital Markets		4,994,531

1

QQQX	Nuveen NASDAQ 100 Dynamic Overwrite Fund (continued)
	Portfolio of Investments    March 31, 2018
	(Unaudited)

Shares		Description (1)	Value
		Chemicals – 0.1%
	2,000	Sherwin-Williams Company	$	784,240
		Commercial Services & Supplies – 0.4%
	10,324	Copart Inc., (2)		525,801
	7,605	KAR Auction Services Inc.		412,191
	15,000	Tetra Tech, Inc.		734,250
	7,182	Waste Connections Inc.		515,237
	9,417	Waste Management, Inc.		792,158
		Total Commercial Services & Supplies		2,979,637
		Communications Equipment – 4.3%
	810,000	Cisco Systems, Inc.		34,740,900
	5,000	F5 Networks, Inc., (2)		723,050
		Total Communications Equipment		35,463,950
		Containers & Packaging – 0.1%
	3,000	Ball Corporation		119,130
	10,000	International Paper Company		534,300
		Total Containers & Packaging		653,430
		Distributors – 0.4%
	3,449	Genuine Parts Company		309,858
	40,000	LKQ Corporation, (2)		1,518,000
	7,800	Pool Corporation		1,140,516
		Total Distributors		2,968,374
		Diversified Consumer Services – 0.2%
	43,200	Service Corporation International		1,630,368
		Electrical Equipment – 0.2%
	9,400	Rockwell Automation, Inc.		1,637,480
		Electronic Equipment, Instruments & Components – 0.4%
	12,148	Amphenol Corporation, Class A		1,046,307
	3,675	Arrow Electronics, Inc., (2)		283,049
	5,960	Avnet Inc.		248,890
	30,310	Corning Incorporated		845,043
	7,692	Keysight Technologies, Inc., (2)		402,984
	13,756	National Instruments Corporation		695,641
		Total Electronic Equipment, Instruments & Components		3,521,914
		Energy Equipment & Services – 0.1%
	32,600	Nabors Industries Inc.		227,874
	37,300	Transocean Inc.		369,270
		Total Energy Equipment & Services		597,144
		Equity Real Estate Investment Trusts – 0.3%
	18,413	Apartment Investment & Management Company, Class A		750,330
	54,600	CubeSmart		1,539,720
	59,600	Developers Diversified Realty Corporation		436,868
		Total Equity Real Estate Investment Trusts		2,726,918
		Food & Staples Retailing – 0.3%
	3,800	Casey’s General Stores, Inc.		417,126
	25,300	Kroger Co.		605,682
	8,700	Sysco Corporation		521,652
	20,300	US Foods Holding Corporation, (2)		665,231
		Total Food & Staples Retailing		2,209,691

2

Shares		Description (1)	Value
		Food Products – 0.1%
	15,200	ConAgra Foods, Inc.	$	560,576
	5,300	Hain Celestial Group Inc., (2)		169,971
	11,000	Pilgrim’s Pride Corporation, (2)		270,710
	3,800	Post Holdings Inc., (2)		287,888
		Total Food Products		1,289,145
		Health Care Equipment & Supplies – 1.2%
	68,600	Abbott Laboratories		4,110,512
	8,796	Baxter International, Inc.		572,092
	3,650	Becton, Dickinson and Company, (3)		790,955
	16,000	Danaher Corporation		1,566,560
	8,434	Hill Rom Holdings Inc.		733,758
	3,714	Stryker Corporation, (3)		597,657
	11,100	Zimmer Biomet Holdings, Inc., (3)		1,210,344
		Total Health Care Equipment & Supplies		9,581,878
		Health Care Providers & Services – 0.2%
	4,093	McKesson HBOC Inc., (3)		576,581
	7,946	Universal Health Services, Inc., Class B		940,886
		Total Health Care Providers & Services		1,517,467
		Hotels, Restaurants & Leisure – 0.5%
	20,714	Carnival Corporation		1,358,424
	10,000	Darden Restaurants, Inc.		852,500
	3,000	Domino’s Pizza Inc.		700,680
	29,200	Restaurant Brands International Inc.		1,662,064
		Total Hotels, Restaurants & Leisure		4,573,668
		Household Durables – 0.1%
	41,536	KB Home		1,181,699
		Industrial Conglomerates – 0.1%
	5,740	Honeywell International Inc.		829,487
		Insurance – 0.2%
	23,648	FNF Group		946,393
	12,000	Torchmark Corporation		1,010,040
		Total Insurance		1,956,433
		Internet and Direct Marketing Retail – 12.7%
	60,000	Amazon.com, Inc., (2)		86,840,400
	8,500	Booking Holdings Inc., (2)		17,683,315
		Total Internet and Direct Marketing Retail		104,523,715
		Internet Software & Services – 18.6%
	38,000	Alphabet Inc., Class A, (2)		39,411,320
	39,000	Alphabet Inc., Class C, (2), (3)		40,239,810
	43,000	Baidu Inc., Sponsored ADR, (2), (3)		9,597,170
	210,000	eBay Inc., (2), (3)		8,450,400
	320,000	Facebook Inc., Class A, (2), (3)		51,132,800
	17,600	IAC/InterActiveCorp, (2)		2,752,288
	4,807	J2 Global Inc., (3)		379,368
	30,000	Twitter Inc., (2)		870,300
		Total Internet Software & Services		152,833,456
		IT Services – 3.6%
	7,251	Black Knight, Inc., (2)		341,522
	20,000	CSRA Inc.		824,600
	12,340	DXC Technology Company		1,240,540
	23,800	Fidelity National Information Services, Inc.		2,291,940
	19,208	Genpact Limited		614,464

3

QQQX	Nuveen NASDAQ 100 Dynamic Overwrite Fund (continued)
	Portfolio of Investments    March 31, 2018
	(Unaudited)

Shares		Description (1)	Value
		IT Services (continued)
	16,316	Global Payments Inc.	$	1,819,560
	45,000	Henry Jack and Associates Inc.		5,442,750
	29,448	Infosys Technologies Limited, Sponsored ADR		525,647
	5,008	Leidos Holdings Inc.		327,523
	200,000	PayPal Holdings, Inc., (2)		15,174,000
	8,580	Total System Services Inc.		740,111
		Total IT Services		29,342,657
		Life Sciences Tools & Services – 0.5%
	58,000	Agilent Technologies, Inc.		3,880,200
	4,788	Charles River Laboratories International, Inc., (2)		511,071
		Total Life Sciences Tools & Services		4,391,271
		Machinery – 0.2%
	9,526	Caterpillar Inc.		1,403,942
	8,005	Fortive Corporation		620,548
		Total Machinery		2,024,490
		Media – 3.4%
	4,900	AMC Networks Inc., Class A, (2)		253,330
	19,200	CBS Corporation		986,688
	9,700	Cinemark Holdings Inc.		365,399
	680,000	Comcast Corporation, Class A, (3)		23,235,600
	66,088	News Corporation, Class B		1,064,017
	79,632	News Corporation, Class A		1,258,186
	6,836	WPP Group PLC, Sponsored ADR		543,804
		Total Media		27,707,024
		Multiline Retail – 0.2%
	63,700	J.C. Penney Company, Inc.		192,374
	6,900	Kohl’s Corporation		452,019
	10,100	Target Corporation		701,243
		Total Multiline Retail		1,345,636
		Oil, Gas & Consumable Fuels – 0.4%
	7,600	Anadarko Petroleum Corporation		459,116
	11,800	Antero Resources Corporation, (2)		234,230
	8,700	Continental Resources Inc., (2)		512,865
	9,300	Devon Energy Corporation		295,647
	16,200	Gulfport Energy Corporation, (2)		156,330
	23,900	Marathon Oil Corporation		385,507
	11,300	Noble Energy, Inc.		342,390
	25,700	QEP Resources Inc.		251,603
	15,400	Range Resources Corporation		223,916
	38,600	Southwestern Energy Company, (2)		167,138
		Total Oil, Gas & Consumable Fuels		3,028,742
		Pharmaceuticals – 0.1%
	5,960	Jazz Pharmaceuticals, Inc., (2)		899,900
		Professional Services – 0.4%
	10,307	IHS Markit Limited, (2)		497,210
	11,461	ManpowerGroup Inc.		1,319,161
	19,598	Robert Half International Inc.		1,134,528
		Total Professional Services		2,950,899
		Semiconductors & Semiconductor Equipment – 11.7%
	4,000	Ambarella, Incorporated, (2)		195,960
	92,000	Analog Devices, Inc.		8,383,960
	313,316	Applied Materials, Inc., (3)		17,423,503
	17,789	Integrated Device Technology, Inc., (2)		543,632

4

Shares		Description (1)	Value
		Semiconductors & Semiconductor Equipment (continued)
	650,100	Intel Corporation, (3)	$	33,857,208
	8,107	Microsemi Corporation, (2)		524,685
	82,500	NVIDIA Corporation		19,106,175
	27,886	ON Semiconductor Corporation, (2)		682,092
	5,933	Power Integrations Inc.		405,521
	236,000	QUALCOMM, Inc., (3)		13,076,760
	10,146	Silicon Laboratories Inc., (2)		912,125
	20,000	Taiwan Semiconductor Manufacturing Company Limited, Sponsored ADR		875,200
		Total Semiconductors & Semiconductor Equipment		95,986,821
		Software – 14.0%
	18,000	Ansys Inc., (2)		2,820,420
	54,000	Autodesk, Inc., (2)		6,781,320
	11,986	CDK Global Inc.		759,193
	16,040	Imperva Incorporated, (2)		694,532
	975,000	Microsoft Corporation, (3)		88,988,250
	1,584	Microstrategy Inc., Class A, (2), (3)		204,320
	22,224	Open Text Corporation		773,395
	40,000	Oracle Corporation		1,830,000
	12,402	Parametric Technology Corporation, (2)		967,480
	16,000	Red Hat, Inc., (2)		2,392,160
	7,500	ServiceNow Inc., (2)		1,240,875
	76,447	Snap Incorporated, Class A, (2)		1,213,214
	30,000	Take-Two Interactive Software, Inc., (2)		2,933,400
	24,787	Workday Inc., Class A, (2)		3,150,676
		Total Software		114,749,235
		Specialty Retail – 0.8%
	14,900	Aaron Rents Inc.		694,340
	4,472	Advance Auto Parts, Inc.		530,156
	800	AutoZone, Inc., (2)		518,952
	16,500	Bed Bath and Beyond Inc.		346,335
	20,000	CarMax, Inc., (2)		1,238,800
	17,540	Dick’s Sporting Goods Inc.		614,777
	9,300	Foot Locker, Inc.		423,522
	25,551	L Brands Inc.		976,304
	14,500	Michaels Cos Inc., (2)		285,795
	14,000	Sally Beauty Holdings Inc., (2)		230,300
	17,800	Urban Outfitters, Inc., (2)		657,888
		Total Specialty Retail		6,517,169
		Technology Hardware, Storage & Peripherals – 12.7%
	616,400	Apple, Inc., (3)		103,419,592
	19,045	Hewlett Packard Enterprise Co		334,049
	19,045	HP Inc.		417,466
		Total Technology Hardware, Storage & Peripherals		104,171,107
		Textiles, Apparel & Luxury Goods – 0.4%
	7,396	PVH Corporation		1,119,976
	3,800	Ralph Lauren Corporation		424,840
	17,800	Skechers USA Inc., Class A, (2)		692,242
	26,889	Under Armour Inc., Class C, (2)		385,857
	42,700	Under Armour, Inc., Class A, (2)		698,145
		Total Textiles, Apparel & Luxury Goods		3,321,060
		Tobacco – 0.1%
	10,023	Philip Morris International		996,286
		Wireless Telecommunication Services – 0.1%
	28,600	Sprint Corporation, (2)		139,568
	19,244	Telephone and Data Systems Inc.		539,409
	13,012	United States Cellular Corporation, (2)		522,952
		Total Wireless Telecommunication Services		1,201,929
		Total Common Stocks (cost $286,499,030)		821,925,665

5

QQQX	Nuveen NASDAQ 100 Dynamic Overwrite Fund (continued)
	Portfolio of Investments    March 31, 2018
	(Unaudited)

Shares		Description (1), (4)					Value
		EXCHANGE-TRADED FUNDS – 1.9%
	61,000	SPDR® S&P 500® Trust ETF					$	16,052,150
		Total Exchange-Traded Funds (cost $16,346,433)						16,052,150
		Total Long-Term Investments (cost $302,845,463)						837,977,815
Principal Amount (000)		Description (1)	Coupon		Maturity		Value
		SHORT-TERM INVESTMENTS – 0.2%
		REPURCHASE AGREEMENTS – 0.2%
$	1,403	Repurchase Agreement with Fixed Income Clearing Corporation, dated 3/29/18, repurchase price $1,403,293, collateralized by $1,470,000 U.S. Treasury Notes, 2.125%, due 9/30/24, value $1,434,871		0.740%		4/02/18	$	1,403,178
		Total Short-Term Investments (cost $1,403,178)						1,403,178
		Total Investments (cost $304,248,641) – 102.1%						839,380,993
		Other Assets Less Liabilities – (2.1)% (5)						(17,282,847	)
		Net Assets – 100%					$	822,098,146

Investments in Derivatives

Options Purchased

Description (6)	Type		Number of Contracts		Notional Amount (7)		Exercise Price		Expiration Date		Value
iShares MSCI Emerging Markets ETF		Put		200	$	920,000	$	46		4/20/18	$	8,800
Total Options Purchased (premiums paid $12,608)				200	$	920,000					$	8,800

Options Written

Description (6)	Type		Number of Contracts			Notional Amount (7)			Exercise Price		Expiration Date		Value
NASDAQ 100® Index		Call		(420	)	$	(297,150,000	)	$	7,075		4/20/18	$	(390,600	)
NASDAQ 100® Index		Call		(30	)		(21,300,000	)		7,100		4/20/18		(23,100	)
RUSSELL 2000® Index		Call		(110	)		(17,325,000	)		1,575		4/20/18		(84,700	)
S&P 500® Index		Call		(140	)		(37,800,000	)		2,700		4/20/18		(269,500	)
Total Options Written (premiums received $3,426,740)				(700	)	$	(373,575,000	)					$	(767,900	)

Fair Value Measurements

Fair value is defined as the price that would be received upon selling an investment or transferring a liability in an orderly transaction to an independent buyer in the principal or most advantageous market for the investment. A three-tier hierarchy is used to maximize the use of observable market data and minimize the use of unobservable inputs and to establish classification of fair value measurements for disclosure purposes. Observable inputs reflect the assumptions market participants would use in pricing the asset or liability. Observable inputs are based on market data obtained from sources independent of the reporting entity. Unobservable inputs reflect the reporting entity’s own assumptions about the assumptions market participants would use in pricing the asset or liability. Unobservable inputs are based on the best information available in the circumstances. The following is a summary of the three-tiered hierarchy of valuation input levels.

Level 1 –	Inputs are unadjusted and prices are determined using quoted prices in active markets for identical securities.
Level 2 –	Prices are determined using other significant observable inputs (including quoted prices for similar securities, interest rates, prepayment speeds, credit risk, etc.).
Level 3 –	Prices are determined using significant unobservable inputs (including management’s assumptions in determining the fair value of investments).

6

The inputs or methodologies used for valuing securities are not an indication of the risk associated with investing in those securities. The following is a summary of the Fund’s fair value measurements as of the end of the reporting period:

	Level 1			Level 2		Level 3		Total
Long-Term Investments:
Common Stocks	$	821,925,665		$	—	$	—	$	821,925,665
Exchange-Traded Funds		16,052,150			—		—		16,052,150
Short-Term Investments:
Repurchase Agreements		—			1,403,178		—		1,403,178
Investments in Derivatives:
Options Purchased		8,800			—		—		8,800
Options Written		(767,900	)		—		—		(767,900	)
Total	$	837,218,715		$	1,403,178	$	—	$	838,621,893

Income Tax Information

The following information is presented on an income tax basis. Differences between amounts for financial statement and federal income tax purposes are primarily due to timing differences in recording income, timing differences in recognizing certain gains and losses on investment transactions and the recognition of unrealized gain or loss for tax (mark-to-market) on options contracts. To the extent that differences arise that are permanent in nature, such amounts are reclassified within the capital accounts on the Statement of Assets and Liabilities presented in the annual report, based on their federal tax basis treatment; temporary differences do not require reclassification. Temporary and permanent differences do not impact the net asset value of the Fund.

The tables below present the cost and unrealized appreciation (depreciation) of the Fund’s investment portfolio, as determined on a federal income tax basis, as of March 31, 2018.

For purposes of this disclosure, derivative tax cost is generally the sum of any upfront fees or premiums exchanged and any amounts unrealized for income statement reporting but realized in income and/or capital gains for tax reporting. If a particular derivative category does not disclose any tax unrealized appreciation or depreciation, the change in value of those derivatives have generally been fully realized for tax purposes.

Tax cost of investments	$	304,305,325
Gross unrealized:
Appreciation	$	540,061,355
Depreciation		(4,985,687	)
Net unrealized appreciation (depreciation) of investments	$	535,075,668
Tax cost of options purchased	$	12,608
Net unrealized appreciation (depreciation) of options purchased		(3,808	)
Tax cost of options written	$	(767,900	)
Net unrealized appreciation (depreciation) of options written		—

For Fund portfolio compliance purposes, the Fund’s industry classifications refer to any one or more of the industry sub-classifications used by one or more widely recognized market indexes or ratings group indexes, and/or as defined by Fund management. This definition may not apply for purposes of this report, which may combine industry sub-classifications into sectors for reporting ease.

(1) All percentages shown in the Portfolio of Investments are based on net assets.

(2) Non-income producing; issuer has not declared a dividend within the past twelve months.

(3) Investment, or portion of investment, has been pledged to collateralize the net payment obligations for investments in derivatives.

(4) A copy of the most recent financial statements for these exchange-traded funds can be obtained directly from the Securities and Exchange Commission or on its website http://www.sec.gov.

(5) Other assets less liabilities includes the unrealized appreciation (depreciation) of certain over-the-counter (“OTC”) derivatives as well as the OTC cleared and exchange-traded derivatives, when applicable. Other assets less liabilities also includes the value of options.

(6) Exchange-traded, unless otherwise noted.

(7) For disclosure purposes, Notional Amount is calculated by multiplying the Number of Contracts by the Exercise Price by 100.

ADR American Depositary Receipt.

7

Item 2. Controls and Procedures.

a. The registrant’s principal executive and principal financial officers, or persons performing similar functions, have concluded that the registrant’s disclosure controls and procedures (as defined in Rule 30a-3(c) under the Investment Company Act of 1940, as amended (the “1940 Act”) (17 CFR 270.30a-3(c))) are effective, as of a date within 90 days of the filing date of this report that includes the disclosure required by this paragraph, based on their evaluation of the controls and procedures required by Rule 30a-3(b) under the 1940 Act (17 CFR 270.30a-3(b)) and Rule 13a-15(b) or 15d-15(b) under the Securities Exchange Act of 1934 (17 CFR 240.13a-15(b) or 240.15d-15(b)).

b. There were no changes in the registrant’s internal control over financial reporting (as defined in Rule 30a-3(d) under the 1940 Act (17 CFR 270.30a-3(d)) that occurred during the registrant’s last fiscal quarter that have materially affected, or are reasonably likely to materially affect, the registrant’s internal control over financial reporting.

Item 3. Exhibits.

File as exhibits as part of this Form a separate certification for each principal executive officer and principal financial officer of the registrant as required by Rule 30a-2(a) under the 1940 Act (17 CFR 270.30a-2(a)), exactly as set forth below: EX-99 CERT Attached hereto.

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934 and the Investment Company Act of 1940, the registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized.

(Registrant)	Nuveen NASDAQ 100 Dynamic Overwrite Fund
By (Signature and Title)	/s/ Gifford R. Zimmerman
	Gifford R. Zimmerman
	Vice President and Secretary

Date: May 30, 2018

Pursuant to the requirements of the Securities Exchange Act of 1934 and the Investment Company Act of 1940, this report has been signed below by the following persons on behalf of the registrant and in the capacities and on the dates indicated.

By (Signature and Title)	/s/ Cedric H. Antosiewicz
	Cedric H. Antosiewicz
	Chief Administrative Officer (principal executive officer)
Date: May 30, 2018
By (Signature and Title)	/s/ Stephen D. Foy
	Stephen D. Foy
	Vice President and Controller (principal financial officer)
Date: May 30, 2018