UNITED STATES SECURITIES AND EXCHANGE COMMISSION

Washington, DC 20549

FORM N-Q

QUARTERLY SCHEDULE OF PORTFOLIO HOLDINGS OF REGISTERED MANAGEMENT INVESTMENT COMPANY

Investment Company Act file number 811-22971

Nuveen NASDAQ 100 Dynamic Overwrite Fund

(Exact name of registrant as specified in charter)

    333 West Wacker Drive, Chicago, Illinois 60606    

(Address of principal executive offices) (Zip code)

Gifford R. Zimmerman—Vice President and Secretary

    333 West Wacker Drive, Chicago, Illinois 60606    

(Name and address of agent for service)

Registrant’s telephone number, including area code:     312-917-7700    

Date of fiscal year end:       December 31      

Date of reporting period:  March 31, 2017  

Form N-Q is to be used by management investment companies, other than small business investment companies registered on Form N-5 (§§ 239.24 and 274.5 of this chapter), to file reports with the Commission, not later than 60 days after the close of the first and third fiscal quarters, pursuant to rule 30b1-5 under the Investment Company Act of 1940 (17 CFR 270.30b1-5). The Commission may use the information provided on Form N-Q in its regulatory, disclosure review, inspection, and policymaking roles.

A registrant is required to disclose the information specified by Form N-Q, and the Commission will make this information public. A registrant is not required to respond to the collection of information contained in Form N-Q unless the Form displays a currently valid Office of Management and Budget (“OMB”) control number. Please direct comments concerning the accuracy of the information collection burden estimate and any suggestions for reducing the burden to the Secretary, Securities and Exchange Commission, 450 Fifth Street, NW, Washington, DC 20549-0609. The OMB has reviewed this collection of information under the clearance requirements of 44 U.S.C. § 3507.

Item 1. Schedule of Investments

QQQX

Nuveen Nasdaq 100 Dynamic Overwrite Fund
Portfolio of Investments	March 31, 2017 (Unaudited)

Shares		Description (1)	Value
		LONG-TERM INVESTMENTS – 101.8%
		COMMON STOCKS – 100.6%
		Aerospace & Defense – 0.1%
	4,954	Boeing Company	$	876,164
		Air Freight & Logistics – 0.1%
	2,768	FedEx Corporation		540,175
		Airlines – 0.5%
	31,069	Delta Air Lines, Inc.		1,427,931
	6,742	Ryanair Holdings PLC, Sponsored ADR		559,451
	26,363	Southwest Airlines Co.		1,417,275
		Total Airlines		3,404,657
		Auto Components – 0.2%
	26,602	American Axle and Manufacturing Holdings Inc.		499,585
	21,986	Gentex Corporation		468,961
	4,227	Lear Corporation		598,459
		Total Auto Components		1,567,005
		Automobiles – 1.1%
	49,165	Ford Motor Company		572,281
	14,597	Harley-Davidson, Inc.		883,119
	23,900	Tesla Motors Inc., (2)		6,651,370
		Total Automobiles		8,106,770
		Beverages – 0.6%
	8,894	Brown-Forman Corporation		410,725
	91,000	Monster Beverage Corporation, (2)		4,201,470
		Total Beverages		4,612,195
		Biotechnology – 9.9%
	7,091	AbbVie Inc.		462,050
	12,000	Agios Pharmaceutical Inc., (2)		700,800
	35,000	Alexion Pharmaceuticals Inc., (2)		4,243,400
	14,052	Alkermes PLC, (2)		822,042
	117,100	Amgen Inc.		19,212,597
	178,024	Celgene Corporation, (2), (3)		22,151,526
	239,725	Gilead Sciences, Inc., (3)		16,282,122
	64,749	Immunogen, Inc., (2)		250,579
	22,236	Ionis Pharmaceuticals, Inc., (2)		893,887
	12,904	Myriad Genetics Inc., (2)		247,757
	20,000	Regeneron Pharmaceuticals, Inc., (2)		7,750,200
	12,177	Seattle Genetics, Inc., (2)		765,446
	3,617	United Therapeutics Corporation, (2)		489,669
		Total Biotechnology		74,272,075
		Capital Markets – 0.4%
	9,902	Moody’s Corporation		1,109,420
	24,475	Morgan Stanley		1,048,509
	11,627	SEI Investments Company		586,466
	5,883	T. Rowe Price Group Inc.		400,926
		Total Capital Markets		3,145,321
		Commercial Services & Supplies – 0.4%
	3,842	Cintas Corporation		486,167

NUVEEN 1

QQQX	Nuveen Nasdaq 100 Dynamic Overwrite Fund
	Portfolio of Investments (continued)	March 31, 2017 (Unaudited)

Shares		Description (1)	Value
		Commercial Services & Supplies (continued)
	5,162	Copart Inc., (2)	$	319,683
	7,605	KAR Auction Services Inc.		332,110
	15,000	Tetra Tech, Inc.		612,750
	4,788	Waste Connections Inc.		422,397
	9,417	Waste Management, Inc.		686,688
		Total Commercial Services & Supplies		2,859,795
		Communications Equipment – 3.7%
	818,295	Cisco Systems, Inc., (3)		27,658,371
		Distributors – 0.3%
	3,449	Genuine Parts Company		318,722
	40,570	LKQ Corporation, (2)		1,187,484
	7,800	Pool Corporation		930,774
		Total Distributors		2,436,980
		Diversified Consumer Services – 0.2%
	43,275	Service Corporation International		1,336,332
		Electrical Equipment – 0.2%
	9,416	Rockwell Automation, Inc.		1,466,165
		Electronic Equipment, Instruments & Components – 0.4%
	12,148	Amphenol Corporation, Class A		864,573
	3,675	Arrow Electronics, Inc., (2)		269,782
	5,960	Avnet Inc.		272,730
	30,310	Corning Incorporated		818,370
	7,692	Keysight Technologies, Inc., (2)		277,989
	13,756	National Instruments Corporation		447,895
		Total Electronic Equipment, Instruments & Components		2,951,339
		Equity Real Estate Investment Trusts – 0.4%
	18,413	Apartment Investment & Management Company, Class A		816,616
	54,624	CubeSmart		1,418,039
	12,035	Ventas Inc.		782,756
		Total Equity Real Estate Investment Trusts		3,017,411
		Food & Staples Retailing – 1.8%
	165,441	Walgreens Boots Alliance Inc., (3)		13,739,875
		Health Care Equipment & Supplies – 1.1%
	68,636	Abbott Laboratories		3,048,125
	8,796	Baxter International, Inc.		456,161
	3,650	Becton, Dickinson and Company, (3)		669,556
	16,011	Danaher Corporation		1,369,421
	8,434	Hill-Rom Holdings Inc.		595,440
	3,714	Stryker Corporation, (3)		488,948
	11,178	Zimmer Biomet Holdings, Inc., (3)		1,364,946
		Total Health Care Equipment & Supplies		7,992,597
		Health Care Providers & Services – 1.3%
	11,171	Cardinal Health, Inc.		910,995
	105,849	Express Scripts Holding Company, (2), (3)		6,976,508
	4,093	McKesson HBOC Inc., (3)		606,828
	7,946	Universal Health Services, Inc., Class B		988,880
		Total Health Care Providers & Services		9,483,211
		Hotels, Restaurants & Leisure – 0.8%
	2,500	Buffalo Wild Wings, Inc., (2)		381,875
	20,714	Carnival Corporation		1,220,262

2 NUVEEN

Shares		Description (1)	Value
		Hotels, Restaurants & Leisure (continued)
	3,000	Dominos Pizza Inc.	$	552,900
	5,011	Panera Bread Company, (2)		1,312,231
	29,269	Restaurant Brands International Inc.		1,631,454
	10,396	Wynn Resorts Ltd		1,191,486
		Total Hotels, Restaurants & Leisure		6,290,208
		Household Durables – 0.3%
	41,536	KB Home		825,736
	7,376	Whirlpool Corporation		1,263,730
		Total Household Durables		2,089,466
		Industrial Conglomerates – 0.3%
	40,028	General Electric Company		1,192,834
	5,740	Honeywell International Inc.		716,754
		Total Industrial Conglomerates		1,909,588
		Insurance – 0.3%
	12,439	American International Group, Inc.		776,567
	23,648	FNF Group		920,853
	12,000	Torchmark Corporation		924,480
		Total Insurance		2,621,900
		Internet and Direct Marketing Retail – 10.1%
	67,690	Amazon.com, Inc., (2)		60,009,893
	11,995	HSN, Inc.		445,014
	8,563	Priceline Group, Inc. (The), (2)		15,241,883
		Total Internet and Direct Marketing Retail		75,696,790
		Internet Software & Services – 18.9%
	43,744	Alphabet Inc., Class A, (2)		37,086,163
	49,942	Alphabet Inc., Class C, (2), (3)		41,429,885
	43,473	Baidu Inc., ADR, (2), (3)		7,499,962
	219,900	eBay Inc., (2), (3)		7,382,043
	325,000	Facebook Inc., Class A, (2), (3)		46,166,250
	17,621	IAC/InterActiveCorp, (3)		1,299,020
	4,807	J2 Global Inc.		403,355
	5,270	WebMD Health Corporation, Class A, (2)		277,624
		Total Internet Software & Services		141,544,302
		IT Services – 3.0%
	10,704	Computer Sciences Corporation		738,683
	10,704	CSRA Inc.		313,520
	23,804	Fidelity National Information Services, Inc.		1,895,274
	19,208	Genpact Limited		475,590
	16,316	Global Payments Inc.		1,316,375
	41,035	Henry Jack and Associates Inc.		3,820,358
	29,448	Infosys Technologies Limited, Sponsored ADR		465,278
	5,008	Leidos Holdings Inc.		256,109
	68,363	Paychex, Inc.		4,026,581
	200,000	PayPal Holdings, Inc., (2)		8,604,000
	8,580	Total System Services Inc.		458,687
		Total IT Services		22,370,455
		Life Sciences Tools & Services – 0.5%
	58,385	Agilent Technologies, Inc.		3,086,815
	4,788	Charles River Laboratories International, Inc., (2)		430,681
		Total Life Sciences Tools & Services		3,517,496

NUVEEN 3

QQQX	Nuveen Nasdaq 100 Dynamic Overwrite Fund
	Portfolio of Investments (continued)	March 31, 2017 (Unaudited)

Shares		Description (1)	Value
		Machinery – 0.2%
	9,526	Caterpillar Inc.	$	883,632
	8,005	Fortive Corporation		482,061
		Total Machinery		1,365,693
		Media – 4.2%
	19,288	CBS Corporation, Class B		1,337,816
	680,000	Comcast Corporation, Class A, (3)		25,561,200
	66,088	News Corporation Class B		892,188
	79,632	News Corporation, Class A		1,035,216
	20,124	Omnicom Group, Inc.		1,734,890
	6,836	WPP Group PLC, Sponsored ADR		747,858
		Total Media		31,309,168
		Multiline Retail – 0.0%
	63,200	J.C. Penney Company, Inc.		389,312
		Pharmaceuticals – 0.3%
	3,505	Allergan PLC		837,415
	22,511	Endo International PLC, (2)		251,223
	1,000	Heska Corporation, (2)		102,972
	5,960	Jazz Pharmaceuticals, Inc., (2)		864,975
		Total Pharmaceuticals		2,056,585
		Professional Services – 0.7%
	10,307	IHS Markit Limited, (2)		432,379
	11,461	Manpower Inc.		1,175,555
	19,598	Robert Half International Inc.		956,970
	31,037	Verisk Analytics Inc, Class A, (2)		2,518,342
		Total Professional Services		5,083,246
		Road & Rail – 0.1%
	4,374	J.B. Hunt Transports Services Inc.		401,271
		Semiconductors & Semiconductor Equipment – 10.2%
	92,608	Analog Devices, Inc.		7,589,226
	160,000	Applied Materials, Inc.		6,224,000
	17,789	Integrated Device Technology, Inc., (2)		421,066
	753,388	Intel Corporation, (3)		27,174,705
	55,842	Lam Research Corporation		7,167,879
	8,107	Microsemi Corporation, (2)		417,754
	105,553	NVIDIA Corporation		11,497,888
	27,886	ON Semiconductor Corporation, (2)		431,954
	5,933	Power Integrations Inc.		390,095
	236,998	QUALCOMM, Inc., (3)		13,589,465
	10,146	Silicon Laboratories Inc., (2)		746,238
	20,000	Taiwan Semiconductor Manufacturing Company Limited, Sponsored ADR		656,800
	7,657	Xperi Corporation		259,955
		Total Semiconductors & Semiconductor Equipment		76,567,025
		Software – 12.4%
	18,065	Ansys Inc., (2)		1,930,607
	53,540	Autodesk, Inc., (2)		4,629,604
	51,724	Cadence Design Systems, Inc., (2)		1,624,134
	11,986	CDK Global Inc.		779,210
	54,089	Electronic Arts Inc., (2)		4,842,047
	1,097,453	Microsoft Corporation		72,278,255
	1,584	Microstrategy Inc., (2)		297,475
	22,224	Open Text Corporation		755,838
	49,954	Oracle Corporation		2,228,448
	12,402	Parametric Technology Corporation, (2)		651,725
	15,606	Red Hat, Inc., (2)		1,349,919

4 NUVEEN

Shares		Description (1)					Value
		Software (continued)
	25,778	Synopsys Inc., (2), (3)					$	1,859,367
		Total Software						93,226,629
		Specialty Retail – 0.7%
	14,900	Aaron Rents Inc.						443,126
	4,472	Advance Auto Parts, Inc.						663,019
	28,481	CarMax, Inc., (2)						1,686,645
	17,540	Dick’s Sporting Goods Inc.						853,496
	25,551	L Brands Inc.						1,203,452
	9,285	Signet Jewelers Limited						643,172
		Total Specialty Retail						5,492,910
		Technology Hardware, Storage & Peripherals – 14.1%
	730,000	Apple, Inc., (3)						104,871,800
	19,045	Hewlett Packard Enterprise Company						451,366
	19,045	HP Inc.						340,525
		Total Technology Hardware, Storage & Peripherals						105,663,691
		Textiles, Apparel & Luxury Goods – 0.4%
	14,784	Coach, Inc.						611,023
	7,396	PVH Corporation						765,264
	17,800	Skechers USA Inc., (2)						488,610
	26,889	Under Armour Inc, Class C, (2)						492,069
	42,700	Under Armour, Inc., (2)						844,606
		Total Textiles, Apparel & Luxury Goods						3,201,572
		Tobacco – 0.3%
	12,975	Altria Group, Inc.						926,674
	10,023	Philip Morris International, Inc.						1,131,597
		Total Tobacco						2,058,271
		Wireless Telecommunication Services – 0.1%
	19,244	Telephone and Data Systems Inc.						510,158
	13,012	United States Cellular Corporation, (2)						485,738
		Total Wireless Telecommunication Services						995,896
		Total Common Stocks (cost $311,540,785)						753,317,912
Shares		Description (1), (4)					Value
		EXCHANGE-TRADED FUNDS – 1.2%
	4,000	iShares NASDAQ Biotechnology ETF					$	1,173,080
	60,000	PowerShares QQQ Trust, Series 1						7,942,800
		Total Exchange-Traded Funds (cost $8,316,490)						9,115,880
		Total Long-Term Investments (cost $319,857,275)						762,433,792
Principal Amount (000)		Description (1)	Coupon		Maturity		Value
		SHORT-TERM INVESTMENTS – 0.1%
		REPURCHASE AGREEMENTS – 0.1%
$	554	Repurchase Agreement with Fixed Income Clearing Corporation, dated 3/31/17, repurchase price $553,796, collateralized by $555,000 U.S. Treasury Bonds, 3.125%, due 8/15/44, value $566,995		0.090%		4/03/17	$	553,792
		Total Short-Term Investments (cost $553,792)						553,792
		Total Investments (cost $320,411,067) – 101.9%						762,987,584
		Other Assets Less Liabilities – (1.9)% (5)						(13,926,782	)
		Net Assets – 100%					$	749,060,802

NUVEEN 5

QQQX	Nuveen Nasdaq 100 Dynamic Overwrite Fund
	Portfolio of Investments (continued)	March 31, 2017 (Unaudited)

Investments in Derivatives as of March 31, 2017

Options Purchased

Options Type	Number of Contracts		Description (6)	Notional Amount (7)		Expiration Date		Strike Price		Value
Call		100	Alerian MLP ETF	$	130,000		4/21/17	$	13	$	250
Call		100	Hasbro, Inc.		1,050,000		4/21/17		105		3,000
Put		200	iShares Emerging Markets ETF		780,000		4/21/17		39		7,408
Call		100	Quest Diagnostics Inc.		1,050,000		4/21/17		105		2,250
Call		300	United States Oil Fund LP		300,000		4/21/17		10		21,150
		800	Total Options Purchased (premiums paid $36,847)	$	3,310,000					$	34,058

Options Written

Options Type	Number of Contracts			Description (6)	Notional Amount (7)			Expiration Date		Strike Price		Value
Call		(10	)	NASDAQ 100® Index	$	(5,420,000	)		4/21/17	$	5,420	$	(55,900	)
Call		(75	)	NASDAQ 100® Index		(40,875,000	)		4/21/17		5,450		(332,097	)
Call		(425	)	NASDAQ 100® Index		(230,562,500	)		4/21/17		5,425		(2,244,000	)
Call		(166	)	S&P 500® Index		(39,591,000	)		4/21/17		2,385		(134,460	)
Call		(296	)	S&P 500® Index		(71,040,000	)		4/21/17		2,400		(125,800	)
		(972	)	Total Options Written (premiums received $3,051,625)	$	(387,488,500	)					$	(2,892,257	)

Fair Value Measurements

Fair value is defined as the price that would be received upon selling an investment or transferring a liability in an orderly transaction to an independent buyer in the principal or most advantageous market for the investment. A three-tier hierarchy is used to maximize the use of observable market data and minimize the use of unobservable inputs and to establish classification of fair value measurements for disclosure purposes. Observable inputs reflect the assumptions market participants would use in pricing the asset or liability. Observable inputs are based on market data obtained from sources independent of the reporting entity. Unobservable inputs reflect the reporting entity’s own assumptions about the assumptions market participants would use in pricing the asset or liability. Unobservable inputs are based on the best information available in the circumstances. The following is a summary of the three-tiered hierarchy of valuation input levels.

Level 1 –	Inputs are unadjusted and prices are determined using quoted prices in active markets for identical securities.
Level 2 –	Prices are determined using other significant observable inputs (including quoted prices for similar securities, interest rates, prepayment speeds, credit risk, etc.).
Level 3 –	Prices are determined using significant unobservable inputs (including management’s assumptions in determining the fair value of investments).

The inputs or methodologies used for valuing securities are not an indication of the risk associated with investing in those securities. The following is a summary of the Fund’s fair value measurements as of the end of the reporting period:

	Level 1			Level 2		Level 3		Total
Long-Term Investments:
Common Stocks	$	753,317,912		$	—	$	—	$	753,317,912
Exchange-Traded Funds		9,115,880			—		—		9,115,880
Short-Term Investments:
Repurchase Agreements		—			553,792		—		553,792
Investment in Derivatives:
Options Purchased		34,058			—		—		34,058
Options Written		(2,892,257	)		—		—		(2,892,257	)
Total	$	759,575,593		$	553,792	$	—	$	760,129,385

6 NUVEEN

Income Tax Information

The following information is presented on an income tax basis. Differences between amounts for financial statement and federal income tax purposes are primarily due to timing differences in recording income, timing differences in recognizing certain gains and losses on investment transactions and the recognition of unrealized gain or loss for tax (mark-to-market) on options contracts. To the extent that differences arise that are permanent in nature, such amounts are reclassified within the capital accounts on the Statement of Assets and Liabilities presented in the annual report, based on their federal tax basis treatment; temporary differences do not require reclassification. Temporary and permanent differences do not impact the net asset value of the Fund.

As of March 31, 2017, the cost of investments (excluding investments in derivatives) was $320,444,188.

Gross unrealized appreciation and gross unrealized depreciation of investments (excluding investments in derivatives) as of March 31, 2017, were as follows:

Gross unrealized:
Appreciation	$	446,814,164
Depreciation		(4,270,768	)
Net unrealized appreciation (depreciation) of investments	$	442,543,396

For Fund portfolio compliance purposes, the Fund’s industry classifications refer to any one or more of the industry sub-classifications used by one or more widely recognized market indexes or ratings group indexes, and/or as defined by Fund management. This definition may not apply for purposes of this report, which may combine industry sub-classifications into sectors for reporting ease.

(1) All percentages shown in the Portfolio of Investments are based on net assets.

(2) Non-income producing; issuer has not declared a dividend within the past twelve months.

(3) Investment, or portion of investment, has been pledged to collateralize the net payment obligations for investments in derivatives.

(4) A copy of the most recent financial statements for these exchange-traded funds can be obtained directly from the Securities and Exchange Commission or on its website http://www.sec.gov.

(5) Other assets less liabilities includes the unrealized appreciation (depreciation) of certain over-the-counter (“OTC”) derivatives as well as the OTC-cleared and exchange-traded derivatives, when applicable. Other assets less liabilities also includes the value of options.

(6) Exchange-traded, unless otherwise noted.

(7) For disclosure purposes, Notional Amount is calculated by multiplying the Number of Contracts by the Strike Price by 100.

ADR American Depositary Receipt

ETF Exchange-Traded Fund

NUVEEN 7

Item 2. Controls and Procedures.

a. The registrant’s principal executive and principal financial officers, or persons performing similar functions, have concluded that the registrant’s disclosure controls and procedures (as defined in Rule 30a-3(c) under the Investment Company Act of 1940, as amended (the “1940 Act”) (17 CFR 270.30a-3(c))) are effective, as of a date within 90 days of the filing date of this report that includes the disclosure required by this paragraph, based on their evaluation of the controls and procedures required by Rule 30a-3(b) under the 1940 Act (17 CFR 270.30a-3(b)) and Rule 13a-15(b) or 15d-15(b) under the Securities Exchange Act of 1934 (17 CFR 240.13a-15(b) or 240.15d-15(b)).

b. There were no changes in the registrant’s internal control over financial reporting (as defined in Rule 30a-3(d) under the 1940 Act (17 CFR 270.30a-3(d)) that occurred during the registrant’s last fiscal quarter that have materially affected, or are reasonably likely to materially affect, the registrant’s internal control over financial reporting.

Item 3. Exhibits.

File as exhibits as part of this Form a separate certification for each principal executive officer and principal financial officer of the registrant as required by Rule 30a-2(a) under the 1940 Act (17 CFR 270.30a-2(a)), exactly as set forth below: EX-99 CERT Attached hereto.

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934 and the Investment Company Act of 1940, the registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized.

(Registrant)	Nuveen NASDAQ 100 Dynamic Overwrite Fund
By (Signature and Title)	/s/ Gifford R. Zimmerman
	Gifford R. Zimmerman
	Vice President and Secretary

Date: May 30, 2017

Pursuant to the requirements of the Securities Exchange Act of 1934 and the Investment Company Act of 1940, this report has been signed below by the following persons on behalf of the registrant and in the capacities and on the dates indicated.

By (Signature and Title)	/s/ Cedric H. Antosiewicz
	Cedric H. Antosiewicz
	Chief Administrative Officer (principal executive officer)
Date: May 30, 2017
By (Signature and Title)	/s/ Stephen D. Foy
	Stephen D. Foy
	Vice President and Controller (principal financial officer)
Date: May 30, 2017