UNITED STATES SECURITIES AND EXCHANGE COMMISSION

Washington, DC 20549

FORM N-Q

QUARTERLY SCHEDULE OF PORTFOLIO HOLDINGS OF REGISTERED MANAGEMENT INVESTMENT COMPANY

Investment Company Act file number 811-22971

Nuveen Nasdaq 100 Dynamic Overwrite Fund

(Exact name of registrant as specified in charter)

    333 West Wacker Drive, Chicago, Illinois 60606    

(Address of principal executive offices) (Zip code)

Kevin J. McCarthy—Vice President and Secretary

    333 West Wacker Drive, Chicago, Illinois 60606    

(Name and address of agent for service)

Registrant’s telephone number, including area code:     312-917-7700    

Date of fiscal year end:       December 31      

Date of reporting period:  September 30, 2015  

Form N-Q is to be used by management investment companies, other than small business investment companies registered on Form N-5 (§§ 239.24 and 274.5 of this chapter), to file reports with the Commission, not later than 60 days after the close of the first and third fiscal quarters, pursuant to rule 30b1-5 under the Investment Company Act of 1940 (17 CFR 270.30b1-5). The Commission may use the information provided on Form N-Q in its regulatory, disclosure review, inspection, and policymaking roles.

A registrant is required to disclose the information specified by Form N-Q, and the Commission will make this information public. A registrant is not required to respond to the collection of information contained in Form N-Q unless the Form displays a currently valid Office of Management and Budget (“OMB”) control number. Please direct comments concerning the accuracy of the information collection burden estimate and any suggestions for reducing the burden to the Secretary, Securities and Exchange Commission, 450 Fifth Street, NW, Washington, DC 20549-0609. The OMB has reviewed this collection of information under the clearance requirements of 44 U.S.C. § 3507.

Item 1. Schedule of Investments

QQQX

Nuveen Nasdaq 100 Dynamic Overwrite Fund
Portfolio of Investments	September 30, 2015 (Unaudited)

Shares		Description (1)	Value
		LONG-TERM INVESTMENTS – 100.7%
		COMMON STOCKS – 95.6%
		Aerospace & Defense – 0.8%
	14,654	Boeing Company	$	1,918,941
	14,106	Honeywell International Inc.		1,335,697
	2,019	Precision Castparts Corporation		463,784
	24,142	United Technologies Corporation		2,148,397
		Total Aerospace & Defense		5,866,819
		Air Freight & Logistics – 0.1%
	2,768	FedEx Corporation		398,537
		Airlines – 0.3%
	12,008	Delta Air Lines, Inc.		538,799
	6,915	Ryanair Holdings PLC, Sponsored ADR		541,445
	26,363	Southwest Airlines Co.		1,002,849
		Total Airlines		2,083,093
		Auto Components – 0.1%
	10,102	American Axle and Manufacturing Holdings Inc.		201,434
	21,986	Gentex Corporation		340,783
	4,227	Lear Corporation		459,813
		Total Auto Components		1,002,030
		Automobiles – 0.2%
	49,165	Ford Motor Company		667,169
	14,597	Harley-Davidson, Inc.		801,375
		Total Automobiles		1,468,544
		Beverages – 0.9%
	4,447	Brown-Forman Corporation		430,914
	36,625	Coca-Cola Company		1,469,395
	15,729	Monster Beverage Corporation, (2)		2,125,617
	24,602	PepsiCo, Inc.		2,319,969
		Total Beverages		6,345,895
		Biotechnology – 10.2%
	34,891	AbbVie Inc.		1,898,419
	10,000	Agios Pharmaceutical Inc., (2)		705,900
	4,121	Alkermes PLC, (2)		241,779
	120,000	Amgen Inc., (3)		16,598,400
	9,126	Baxalta Inc.		287,560
	167,710	Celgene Corporation, (2), (3)		18,141,191
	220,000	Gilead Sciences, Inc., (3)		21,601,800
	6,049	Immunogen, Inc., (2)		58,070
	9,571	Incyte Pharmaceuticals Inc.,		1,055,968
	10,136	ISIS Pharmaceuticals, Inc., (2)		409,697
	12,904	Myriad Genentics Inc., (2)		483,642
	15,000	Regeneron Pharmaceuticals, Inc., (2)		6,977,100
	12,177	Seattle Genetics, Inc., (2)		469,545
	6,117	United Therapeutics Corporation, (2)		802,795
		Total Biotechnology		69,731,866
		Capital Markets – 0.6%
	62,652	Charles Schwab Corporation		1,789,341
	1,581	Goldman Sachs Group, Inc.		274,715

Nuveen Investments 1

QQQX	Nuveen Nasdaq 100 Dynamic Overwrite Fund
	Portfolio of Investments (continued)	September 30, 2015 (Unaudited)

Shares		Description (1)	Value
		Capital Markets (continued)
	24,475	Morgan Stanley	$	770,963
	11,627	SEI Investments Company		560,770
	5,883	T. Rowe Price Group Inc.		408,869
	13,816	Waddell & Reed Financial, Inc., Class A		480,382
		Total Capital Markets		4,285,040
		Chemicals – 0.7%
	2,138	Air Products & Chemicals Inc.		272,766
	4,865	CF Industries Holdings, Inc.		218,439
	4,408	Chemours Company		28,520
	18,504	Dow Chemical Company		784,570
	22,041	E.I. Du Pont de Nemours and Company		1,062,376
	5,970	Ecolab Inc.		655,028
	7,810	Methanex Corporation		258,980
	10,514	Monsanto Company		897,265
	3,448	Praxair, Inc.		351,213
		Total Chemicals		4,529,157
		Commercial Services & Supplies – 0.3%
	3,842	Cintas Corporation		329,452
	5,162	Copart Inc., (2)		169,830
	7,605	KAR Auction Services Inc.		269,978
	15,000	Tetra Tech, Inc.		364,650
	4,788	Waste Connections Inc.		232,601
	9,417	Waste Management, Inc.		469,061
		Total Commercial Services & Supplies		1,835,572
		Communications Equipment – 5.4%
	845,311	Cisco Systems, Inc. (3)		22,189,414
	21,858	Ericsson, Sponsored ADR		213,771
	273,466	QUALCOMM, Inc. (3)		14,693,328
		Total Communications Equipment		37,096,513
		Consumer Finance – 0.2%
	8,310	American Express Company		616,020
	6,671	Capital One Financial Corporation		483,781
	27,215	Navient Corporation		305,897
	27,215	SLM Corporation, (2)		201,391
		Total Consumer Finance		1,607,089
		Containers & Packaging – 0.2%
	17,353	Packaging Corp. of America		1,043,956
	4,824	Sonoco Products Company		182,058
		Total Containers & Packaging		1,226,014
		Distributors – 0.2%
	3,449	Genuine Parts Company		285,888
	40,470	LKQ Corporation, (2)		1,147,729
		Total Distributors		1,433,617
		Diversified Consumer Services – 0.1%
	21,475	Service Corporation International		581,973
		Diversified Financial Services – 0.4%
	3,641	Berkshire Hathaway Inc., Class B, (2)		474,786
	14,599	CME Group, Inc.		1,353,911
	9,902	Moody’s Corporation		972,376
		Total Diversified Financial Services		2,801,073

2 Nuveen Investments

Shares		Description (1)	Value
		Electric Utilities – 0.2%
	48,358	Great Plains Energy Incorporated	$	1,306,633
	10,842	OGE Energy Corp.		296,637
		Total Electric Utilities		1,603,270
		Electrical Equipment – 0.4%
	23,934	Eaton Corporation PLC		1,227,814
	8,327	Hubbell Incorporated, Class B		707,379
	9,416	Rockwell Automation, Inc.		955,442
		Total Electrical Equipment		2,890,635
		Electronic Equipment, Instruments & Components – 0.3%
	12,148	Amphenol Corporation, Class A, (3)		619,062
	3,675	Arrow Electronics, Inc., (2)		203,154
	5,960	Avnet Inc.		254,373
	30,310	Corning Incorporated		518,907
	7,692	Keysight Technologies, Inc., (2)		237,221
	13,756	National Instruments Corporation		382,279
		Total Electronic Equipment, Instruments & Components		2,214,996
		Energy Equipment & Services – 0.4%
	20,122	Cooper Cameron Corporation, (2)		1,233,881
	7,838	Diamond Offshore Drilling, Inc.		135,597
	15,853	Schlumberger Limited		1,093,381
		Total Energy Equipment & Services		2,462,859
		Food & Staples Retailing – 1.9%
	2,453	Casey’s General Stores, Inc.		252,463
	29,337	CVS Health Corporation, (3)		2,830,434
	55,616	Kroger Co.		2,006,069
	80,000	Walgreens Boots Alliance Inc.		6,648,000
	19,233	Wal-Mart Stores, Inc.		1,247,068
		Total Food & Staples Retailing		12,984,034
		Food Products – 0.1%
	10,080	Archer-Daniels-Midland Company		417,816
		Gas Utilities – 0.2%
	18,047	AGL Resources Inc.		1,101,589
		Health Care Equipment & Supplies – 0.8%
	31,753	Abbott Laboratories		1,277,106
	9,126	Baxter International, Inc.		299,789
	3,650	Becton, Dickinson and Company, (3)		484,209
	1,655	C. R. Bard, Inc.		308,343
	12,334	Hill-Rom Holdings Inc.		641,245
	12,792	Saint Jude Medical Inc.		807,047
	3,714	Stryker Corporation		349,487
	11,178	Zimmer Holdings, Inc.		1,049,950
		Total Health Care Equipment & Supplies		5,217,176
		Health Care Providers & Services – 2.6%
	7,890	AmerisourceBergen Corporation		749,471
	7,690	Anthem Inc.		1,076,600
	13,759	Brookdale Senior Living Inc., (2)		315,907
	20,971	Cardinal Health, Inc.		1,610,992
	115,949	Express Scripts Holding Company, (2), (3)		9,387,231
	7,293	McKesson HBOC Inc., (3)		1,349,424
	12,175	Tenet Healthcare Corporation, (2)		449,501
	14,614	UnitedHealth Group Incorporated		1,695,370
	7,946	Universal Health Services, Inc., Class B		991,740
		Total Health Care Providers & Services		17,626,236

Nuveen Investments 3

QQQX	Nuveen Nasdaq 100 Dynamic Overwrite Fund
	Portfolio of Investments (continued)	September 30, 2015 (Unaudited)

Shares		Description (1)	Value
		Health Care Technology – 0.0%
	13,136	Quality Systems Inc.	$	163,937
		Hotels, Restaurants & Leisure – 0.7%
	20,714	Carnival Corporation		1,029,486
	22,319	McDonald’s Corporation		2,199,091
	1,773	Panera Bread Company, (2)		342,916
	1,769	Restaurant Brands International Inc.		63,542
	84,855	The Wendy’s Company		733,996
	13,593	Wynn Resorts Ltd, (3)		722,060
		Total Hotels, Restaurants & Leisure		5,091,091
		Household Durables – 0.4%
	41,536	KB Home		562,813
	36,936	Newell Rubbermaid Inc.		1,466,729
	7,376	Whirlpool Corporation		1,086,190
		Total Household Durables		3,115,732
		Household Products – 0.1%
	5,000	Spectrum Brands Inc.		457,550.00
		Industrial Conglomerates – 0.7%
	8,803	3M Co.		1,248,001
	16,011	Danaher Corporation		1,364,297
	82,528	General Electric Company		2,081,356
		Total Industrial Conglomerates		4,693,654
		Insurance – 0.6%
	12,439	American International Group, Inc.		706,784
	5,268	CNA Financial Corporation		184,011
	29,248	FNF Group		1,037,427
	9,224	Prudential Financial, Inc.		702,961
	12,000	Torchmark Corporation		676,800
	9,130	Travelers Companies, Inc.		908,709
		Total Insurance		4,216,692
		Internet & Catalog Retail – 7.5%
	75,621	Amazon.com, Inc., (2), (3)		38,709,634
	11,995	HSN, Inc.		686,594
	9,963	Priceline Group, Inc. (The), (2)		12,322,836
		Total Internet & Catalog Retail		51,719,064
		Internet Software & Services – 15.5%
	19,016	Akamai Technologies, Inc., (2)		1,313,245
	45,473	Baidu Inc., Sponsored ADR, (2), (3)		6,248,445
	220,000	eBay Inc., (2), (3)		5,376,800
	325,000	Facebook Inc., Class A Shares, (2)		29,217,500
	44,044	Google Inc., Class A, (3)		28,116,368
	52,142	Google Inc., Class C Shares, (3)		31,724,236
	17,621	IAC/InterActiveCorp		1,150,123
	4,807	J2 Global Inc.		340,576
	7,516	Netease.com, Inc., ADR		902,822
	5,270	WebMD Health Corporation, Class A, (2)		209,957
	71,023	Yahoo! Inc.,		2,053,275
		Total Internet Software & Services		106,653,347
		IT Services – 2.5%
	479	Alliance Data Systems Corporation, (2)		124,051
	10,704	Computer Sciences Corporation		657,012
	12,966	Fidelity National Information Services, Inc.		869,759
	19,208	Genpact Limited, (2)		453,501

4 Nuveen Investments

Shares		Description (1)	Value
		IT Services (continued)
	8,158	Global Payments Inc.	$	935,967
	19,648	Henry Jack and Associates Inc.		1,367,697
	29,448	Infosys Technologies Limited, Sponsored ADR		562,162
	15,639	International Business Machines Corporation		2,267,186
	5,008	Leidos Holdings Inc.		206,880
	14,732	MasterCard, Inc.		1,327,648
	31,483	Paychex, Inc.		1,499,535
	220,000	PayPal Holdings, Inc., (2)		6,828,800
	8,580	Total System Services Inc.		389,789
		Total IT Services		17,489,987
		Life Sciences Tools & Services – 0.5%
	15,384	Agilent Technologies, Inc.		528,133
	20,567	Bio-Techne Corporation		1,901,625
	4,788	Charles River Laboratories International, Inc., (2)		304,134
	14,460	ICON plc, (2)		1,026,226
		Total Life Sciences Tools & Services		3,760,118
		Machinery – 0.5%
	9,726	Caterpillar Inc.		635,691
	6,217	Deere & Company		460,058
	19,465	Graco Inc.		1,304,739
	2,000	Joy Global Inc.		29,860
	7,181	Makita Corporation, Sponsored ADR, (4)		379,541
	3,641	Nordson Corporation		229,165
	11,888	SPX Corporation		141,705
	11,888	SPX Flow Inc., (2)		409,304
	2,114	WABCO Holdings Inc.		221,611
		Total Machinery		3,811,674
		Media – 4.3%
	19,288	CBS Corporation, Class B		769,591
	300,000	Comcast Corporation, Class A, (3)		17,064,000
	14,000	Discovery Communications Inc., Class A Shares, (2)		364,420
	14,000	Discovery Communications Inc., Class C Shares, (2)		340,060
	51,332	News Corporation, Class A Shares		647,810
	12,888	News Corporation Class B Shares		165,224
	20,124	Omnicom Group, Inc.		1,326,172
	5,242	Time Warner Cable, Class A		940,258
	21,163	Time Warner Inc.		1,454,956
	205,331	Twenty First Century Fox Inc., Class A Shares		5,539,830
	6,836	WPP Group PLC, Sponsored ADR		711,149
		Total Media		29,323,470
		Multiline Retail – 0.2%
	2,698	Dollar Tree, Inc		179,849
	4,511	Kohl’s Corporation		208,904
	10,757	Macy’s, Inc.		552,049
	2,818	Nordstrom, Inc.		202,079
		Total Multiline Retail		1,142,881
		Multi-Utilities – 0.1%
	7,374	WEC Energy Group, Inc.		385,070
		Oil, Gas & Consumable Fuels – 0.3%
	9,342	Cabot Oil & Gas Corporation		204,216
	22,649	Phillips 66		1,740,349
		Total Oil, Gas & Consumable Fuels		1,944,565
		Paper & Forest Products – 0.1%
	10,899	International Paper Company		411,873

Nuveen Investments 5

QQQX	Nuveen Nasdaq 100 Dynamic Overwrite Fund
	Portfolio of Investments (continued)	September 30, 2015 (Unaudited)

Shares		Description (1)	Value
		Pharmaceuticals – 1.5%
	14,808	Allergan PLC, (2)	$	4,024,962
	6,117	Eli Lilly and Company		511,932
	8,946	Endo International PLC, (2)		619,779
	36,144	Merck & Company Inc.		1,785,152
	73,196	Pfizer Inc.		2,299,086
	6,009	Shire plc, ADR		1,233,227
		Total Pharmaceuticals		10,474,138
10,474,138		Professional Services – 0.6%
	6,314	Equifax Inc.		613,595
	2,798	IHS Inc., (2)		324,568
	11,461	Manpowergroup Inc.		938,541
	19,598	Robert Half International Inc.		1,002,634
	15,000	Verisk Analytics Inc, Class A Shares, (2)		1,108,650
		Total Professional Services		3,987,988
		Real Estate Investment Trust – 0.5%
	18,413	Apartment Investment & Management Company, Class A		681,649
	3,008	Care Capital Properties, Inc.		99,053
	9,319	Crown Castle International Corporation		734,990
	28,958	CubeSmart		787,947
	17,523	Senior Housing Properties Trust		283,873
	12,035	Ventas Inc.		674,682
		Total Real Estate Investment Trust		3,262,194
		Road & Rail – 0.3%
	23,916	CSX Corporation		643,340
	19,779	Heartland Express, Inc.		394,393
	4,374	J.B. Hunt Transports Serives Inc.		312,304
	9,051	Landstar System		574,467
	8,819	Werner Enterprises, Inc.		221,357
		Total Road & Rail		2,145,861
		Semiconductors & Semiconductor Equipment – 5.9%
	40,773	Altera Corporation		2,041,912
	33,698	Analog Devices, Inc., (3)		1,900,904
	47,386	Atmel Corporation		382,405
	28,948	Fairchild Semiconductor International Inc., Class A, (2)		406,430
	17,789	Integrated Device Technology, Inc., (2)		361,117
	776,244	Intel Corporation, (3)		23,395,994
	14,136	Intersil Corporation, Class A		165,391
	13,210	Lam Research Corporation		863,009
	45,919	Linear Technology Corporation		1,852,832
	156,609	Micron Technology, Inc., (2), (3)		2,346,003
	8,107	Microsemi Corporation, (2)		266,072
	78,000	NVIDIA Corporation		1,922,700
	40,000	NXP Semiconductors NV, (2)		3,482,800
	27,886	ON Semiconductor Corporation, (2)		262,128
	5,933	Power Integrations Inc.		250,195
	10,146	Silicon Laboratories Inc., (2)		421,465
	44,749	Siliconware Precision Industries Company Limited, Sponsored ADR		281,247
	2,774	Taiwan Semiconductor Manufacturing Company Limited, Sponsored ADR		57,561
	7,657	Tessera Technologies Inc.		248,163
		Total Semiconductors & Semiconductor Equipment		40,908,328
		Software – 8.9%
	61,118	Activision Blizzard Inc.		1,887,935
	7,378	Ansys Inc., (2)		650,297
	30,000	Autodesk, Inc., (2)		1,324,200
	51,724	Cadence Design Systems, Inc., (2)		1,069,652

6 Nuveen Investments

Shares		Description (1)	Value
		Software (continued)
	11,986	CDK Global Inc.	$	572,691
	1,160,000	Microsoft Corporation, (3)		51,341,600
	1,584	Microstrategy Inc., (2)		311,208
	11,112	Open Text Corporation		497,262
	49,954	Oracle Corporation		1,804,338
	12,402	Parametric Technology Corporation, (2)		393,640
	5,477	Red Hat, Inc., (2)		393,687
	25,778	Synopsys Inc., (2), (3)		1,190,428
		Total Software		61,436,938
		Specialty Retail – 1.2%
	4,472	Advance Auto Parts, Inc.		847,578
	18,980	Ascena Retail Group Inc., (2)		264,012
	1,202	AutoZone, Inc., (2)		870,044
	4,581	CarMax, Inc., (2)		271,745
	3,340	Dick’s Sporting Goods Inc.		165,697
	24,643	Gap, Inc.		702,326
	16,432	L Brands Inc.		1,481,016
	9,254	Rent-A-Center Inc.		224,410
	5,585	Signet Jewelers Limited		760,286
	5,134	Tiffany & Co.		396,447
	24,566	TJX Companies, Inc.		1,754,504
	2,515	Ulta Salon, Cosmetics & Fragrance, Inc., (2)		410,825
	2,384	Williams-Sonoma Inc.		182,018
		Total Specialty Retail		8,330,908
		Technology, Hardware, Storage & Peripherals – 14.1%
	855,000	Apple, Inc., (3)		94,306,500
	36,925	EMC Corporation		892,108
	19,045	HP Inc.		487,742
	24,822	SanDisk Corporation		1,348,579
		Total Technology, Hardware, Storage & Peripherals		97,034,929
		Textiles, Apparel & Luxury Goods – 0.2%
	13,384	Coach, Inc.		387,200
	2,496	PVH Corporation		254,442
	5,000	Under Armour, Inc., (2)		483,900
		Total Textiles, Apparel & Luxury Goods		1,125,542
		Tobacco – 0.4%
	20,575	Altria Group, Inc.		1,119,280
	18,760	Philip Morris International Inc.		1,488,231
		Total Tobacco		2,607,511
		Trading Companies & Distributors – 0.0%
	4,640	MSC Industrial Direct Inc., Class A		283,179
		Wireless Telecommunication Services – 0.3%
	12,000	SBA Communications Corporation, (2)		1,256,880
	19,244	Telephone and Data Systems Inc.		480,330
	13,012	United States Cellular Corporation, (2)		461,015
		Total Wireless Telecommunication Services		2,198,225
		Total Common Stocks (cost $324,844,006)		656,987,889

Nuveen Investments 7

QQQX	Nuveen Nasdaq 100 Dynamic Overwrite Fund
	Portfolio of Investments (continued)	September 30, 2015 (Unaudited)

Shares		Description (1), (5)					Value
		EXCHANGE-TRADED FUNDS – 5.1%
	325,715	PowerShares QQQ Trust, Series 1, (3)					$	33,144,759
	10,000	SPDR® S&P 500® ETF						1,916,300
		Total Exchange-Traded Funds (cost $36,040,347)						35,061,059
		Total Long-Term Investments (cost $360,884,353)						692,048,948
Principal Amount (000)		Description (1)	Coupon		Maturity		Value
		SHORT-TERM INVESTMENTS – 1.0%
		REPURCHASE AGREEMENTS – 1.0%
$	7050	Repurchase Agreement with Fixed Income Clearing Corporation, dated 9/30/15, repurchase price $7,049,782, collateralized by $6,875,000 U.S. Treasury Notes, 2.500%, due 8/15/23, value $7,192,969		0.000%		10/01/15	$	7,049,782
		Total Short-Term Investments (cost $7,049,782)						7,049,782
		Total Investments (cost $367,934,135) – 101.7%						699,098,730
		Other Assets Less Liabilities – (1.7)% (6)						(11,510,992	)
		Net Assets – 100%					$	687,587,738

Investments in Derivatives as of September 30, 2015

Options Written outstanding:

Number of Contracts			Description	Exchange-Traded/ Over-the-Counter	Counterparty	Notional Amount			Expiration Date		Strike Price		Value
	(325	)	CBOE SPX Volatility Index	Exchange-Traded	—	$	(812,500	) (7)		10/21/15	$	25.0000	$	(56,062	)
	(325	)	CBOE SPX Volatility Index	Exchange-Traded	—		(975,000	) (7)		10/21/15		30.0000		(27,625	)
	(100,623	)	Custom Basket1*	Over-the-Counter	BNP Paribas		(10,062,300	) (8)		10/15/15		103.0000		(43,660	)
	(165	)	NASDAQ 100® Index	Exchange-Traded	—		(72,187,500	) (7)		10/16/15		4,375.0000		(188,925	)
	(200	)	NASDAQ 100® Index	Exchange-Traded	—		(88,000,000	) (7)		10/16/15		4,400.0000		(155,000	)
	(80	)	NASDAQ 100® Index	Exchange-Traded	—		(34,800,000	) (7)		11/20/15		4,350.0000		(400,800	)
	(275	)	NASDAQ 100® Index	Exchange-Traded	—		(121,000,000	) (7)		11/20/15		4,400.0000		(1,221,000	)
	(145	)	Russell 2000® Index	Exchange-Traded	—		(16,965,000	) (7)		11/20/15		1,170.0000		(110,925	)
	(145	)	Russell 2000® Index	Exchange-Traded	—		(16,675,000	) (7)		11/20/15		1,150.0000		(193,575	)
	(145	)	Russell 2000® Index	Exchange-Traded	—		(16,820,000	) (7)		11/20/15		1,160.0000		(149,350	)
	(120	)	S&P 400® Midcap Index	Over-the-Counter	Deutsche Bank		(17,400,000	) (7)		10/14/15		1,450.0000		(11,144	)
	(360	)	S&P 500® Index	Exchange-Traded	—		(71,100,000	) (7)		10/16/15		1,975.0000		(322,200	)
	(180	)	S&P 500® Index	Exchange-Traded	—		(35,640,000	) (7)		10/16/15		1,980.0000		(120,600	)
	(103,088	)	Total Options Written (premium received $4,765,241)			$	(502,437,300	)					$	(3,000,866	)

* The following table represents the individual common stock holdings comprising the Custom Basket 1 Options Written as of September 30, 2015.

Shares		Description	Value
	15,250	Anadarko Petroleum Corporation	$	(4,350	)
	8,750	Apple, Inc.		(4,416	)
	13,250	Chevron Corporation		(4,438	)
	21,000	Conocophillips		(4,309	)
	13,000	EOG Resources, Inc.		(4,348	)
	13,750	Exxon Mobil Corporation		(4,348	)
	73,000	Ford Motor Company		(4,534	)
	27,000	Halliburton Company		(4,337	)
	36,500	Twitter, Inc.		(4,303	)
	31,750	Yahoo!, Inc.		(4,277	)
			$	(43,660	)

8 Nuveen Investments

Fair Value Measurements

Fair value is defined as the price that would be received upon selling an investment or transferring a liability in an orderly transaction to an independent buyer in the principal or most advantageous market for the investment. A three-tier hierarchy is used to maximize the use of observable market data and minimize the use of unobservable inputs and to establish classification of fair value measurements for disclosure purposes. Observable inputs reflect the assumptions market participants would use in pricing the asset or liability. Observable inputs are based on market data obtained from sources independent of the reporting entity. Unobservable inputs reflect the reporting entity’s own assumptions about the assumptions market participants would use in pricing the asset or liability. Unobservable inputs are based on the best information available in the circumstances. The following is a summary of the three-tiered hierarchy of valuation input levels.

Level 1 –	Inputs are unadjusted and prices are determined using quoted prices in active markets for identical securities.
Level 2 –	Prices are determined using other significant observable inputs (including quoted prices for similar securities, interest rates, prepayment speeds, credit risk, etc.).
Level 3 –	Prices are determined using significant unobservable inputs (including management’s assumptions in determining the fair value of investments).

The inputs or methodologies used for valuing securities are not an indication of the risks associated with investing in those securities. The following is a summary of the Fund’s fair value measurements as of the end of the reporting period:

	Level 1			Level 2			Level 3		Total
Long-Term Investments:
Common Stocks	$	656,608,348		$	379,541		$	—	$	656,987,889
Exchange-Trade Funds		35,061,059			—			—		35,061,059
Short-Term Investments:
Repurchase Agreements		—			7,049,782			—		7,049,782
Investments in Derivatives:
Options Written		(2,946,062	)		(54,804	)		—		(3,000,866	)
Total	$	688,723,345		$	7,374,519		$	—	$	696,097,864

Income Tax Information

The following information is presented on an income tax basis. Differences between amounts for financial statement and federal income tax purposes are primarily due to timing differences in recording income, timing differences in recognizing certain gains and losses on investment transactions and the recognition of unrealized gain or loss for tax (mark- to market) on option contracts. To the extent that differences arise that are permanent in nature, such amounts are reclassified within the capital accounts on the Statement of Assets and Liabilities presented in the annual report, based on their federal tax basis treatment; temporary differences do not require reclassification. Temporary and permanent differences do not impact the net asset value of the Fund.

As of September 30, 2015, the cost of investments ( excluding investments in derivatives) was $367,992,971.

Gross unrealized appreciation and gross unrealized depreciation of investments (excluding investments in derivatives) as of September 30, 2015, were as follows:

Gross unrealized:
Appreciation	$	335,299,195
Depreciation		(4,193,436	)
Net unrealized appreciation (depreciation) of investments	$	331,105,759

For Fund portfolio compliance purposes, the Fund’s industry classifications refer to any one or more of the industry sub-classifications used by one or more widely recognized market indexes or ratings group indexes, and/or as defined by Fund management. This definition may not apply for purposes of this report, which may combine industry sub-classifications into sectors for reporting ease.

(1) All percentages shown in the Portfolio of Investments are based on net assets.

(2) Non-income producing; issuer has not declared a dividend within the past twelve months.

(3) Investment, or portion of investment, has been pledged to collateralize the net payment obligations for investments in derivatives.

(4) For fair value measurement disclosure purposes, investment classified as Level 2.

(5) A copy of the most recent financial statements for these exchange-traded funds can be obtained directly from the Securities and Exchange Commission on its website at http://www.sec.gov.

(6) Other assets less liabilities includes the unrealized appreciation (depreciation) of certain over-the-counter derivatives as well as the exchange-cleared and exchange-traded derivatives, when applicable. Other assets less liabilities also includes the value of options.

(7) For disclosure purposes, Notional Amount is calculated by multiplying the Number of Contracts by the Strike Price by 100.

(8) For disclosure purposes, Notional Amount is calculated by multiplying the Number of Contracts by $100.

ADR American Depositary Receipt

ETF Exchange-Traded Fund

Nuveen Investments 9

Item 2. Controls and Procedures.

a. The registrant’s principal executive and principal financial officers, or persons performing similar functions, have concluded that the registrant’s disclosure controls and procedures (as defined in Rule 30a-3(c) under the Investment Company Act of 1940, as amended (the “1940 Act”) (17 CFR 270.30a-3(c))) are effective, as of a date within 90 days of the filing date of this report that includes the disclosure required by this paragraph, based on their evaluation of the controls and procedures required by Rule 30a-3(b) under the 1940 Act (17 CFR 270.30a-3(b)) and Rule 13a-15(b) or 15d-15(b) under the Securities Exchange Act of 1934 (17 CFR 240.13a-15(b) or 240.15d-15(b)).

b. There were no changes in the registrant’s internal control over financial reporting (as defined in Rule 30a-3(d) under the 1940 Act (17 CFR 270.30a-3(d)) that occurred during the registrant’s last fiscal quarter that have materially affected, or are reasonably likely to materially affect, the registrant’s internal control over financial reporting.

Item 3. Exhibits.

File as exhibits as part of this Form a separate certification for each principal executive officer and principal financial officer of the registrant as required by Rule 30a-2(a) under the 1940 Act (17 CFR 270.30a-2(a)), exactly as set forth below: EX-99 CERT Attached hereto.

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934 and the Investment Company Act of 1940, the registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized.

(Registrant)	Nuveen Nasdaq 100 Dynamic Overwrite Fund
By (Signature and Title)	/s/ Kevin J. McCarthy
	Kevin J. McCarthy
	Vice President and Secretary

Date: November 27, 2015

Pursuant to the requirements of the Securities Exchange Act of 1934 and the Investment Company Act of 1940, this report has been signed below by the following persons on behalf of the registrant and in the capacities and on the dates indicated.

By (Signature and Title)	/s/ Gifford R. Zimmerman
	Gifford R. Zimmerman
	Chief Administrative Officer (principal executive officer)
Date: November 27, 2015
By (Signature and Title)	/s/ Stephen D. Foy
	Stephen D. Foy
	Vice President and Controller (principal financial officer)
Date: November 27, 2015