<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0206</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2018-12-26</periodOfReport>

    <noSecuritiesOwned>0</noSecuritiesOwned>

    <issuer>
        <issuerCik>0000748790</issuerCik>
        <issuerName>Global Clean Energy Holdings, Inc.</issuerName>
        <issuerTradingSymbol>GCEH</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001608310</rptOwnerCik>
            <rptOwnerName>Pacific Sequoia Holdings LLC</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>250 UNIVERSITY AVENUE</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>PALO ALTO</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
            <rptOwnerZipCode>94301</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001079555</rptOwnerCik>
            <rptOwnerName>SKOLL JEFFREY S</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>250 UNIVERSITY AVENUE</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>PALO ALTO</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
            <rptOwnerZipCode>94301</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>40000000</value>
                    <footnoteId id="F1"/>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                    <footnoteId id="F2"/>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
    </nonDerivativeTable>

    <footnotes>
        <footnote id="F1">Jeffrey S. Skoll, the indirect sole member of Pacific Sequoia Holdings, LLC (&quot;PSH&quot;), may be deemed to share the power to direct the voting and disposition of the shares held by PSH. Each of the reporting persons disclaims beneficial ownership of the reported shares except to the extent of his or its respective pecuniary interest therein.</footnote>
        <footnote id="F2">The shares were assigned to PSH,  AllianceBernstein Venture Fund I, L.P. and Growthworks Canadian Fund Ltd. (collectively, the &quot;Collateral Agent&quot;) pursuant to an assignment agreement.  The Collateral Agent was designated as collateral agent pursuant to a guarantee and security agreement by and between the Collateral Agent and other parties thereto (the &quot;Security Agreement&quot;).  The shares were assigned to the Collateral Agent in partial satisfaction of the obligations owed under the Security Agreement.</footnote>
    </footnotes>

    <remarks></remarks>

    <ownerSignature>
        <signatureName>/s/ Eric Techel, Manager, Pacific Sequoia Holdings</signatureName>
        <signatureDate>2019-02-14</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ Eric Techel, by power of attorney</signatureName>
        <signatureDate>2019-02-14</signatureDate>
    </ownerSignature>
</ownershipDocument>
