Shareholders' Equity (Details 3)	12 Months Ended
	Dec. 31, 2019 $ / shares shares
Class of Warrant or Right [Line Items]
Warrants outstanding	2,859,978
Warrants outstanding and exercisable	2,859,978
December 31, 2015 [Member]
Class of Warrant or Right [Line Items]
Warrants outstanding	4,771	[1]
Exercise price per warrant | $ / shares	$ 7.5	[1]
Warrants outstanding and exercisable	4,771	[1]
November 1, 2016 [Member]
Class of Warrant or Right [Line Items]
Warrants outstanding	97,496	[2]
Exercise price per warrant | $ / shares	$ 118.75	[2]
Warrants outstanding and exercisable	97,496	[2]
Contractual term	Nov. 01, 2021	[2]
December 28, 2016 [Member]
Class of Warrant or Right [Line Items]
Warrants outstanding	1,908	[3]
Exercise price per warrant | $ / shares	$ 7.5	[3]
Warrants outstanding and exercisable	1,908	[3]
November 20, 2018 [Member]
Class of Warrant or Right [Line Items]
Warrants outstanding	126,839	[4]
Exercise price per warrant | $ / shares	$ 7.5	[4]
Warrants outstanding and exercisable	126,839	[4]
Contractual term	Nov. 20, 2023	[5]
November 20, 2018 One [Member]
Class of Warrant or Right [Line Items]
Warrants outstanding	106,680	[6]
Exercise price per warrant | $ / shares	$ 9.375	[6]
Warrants outstanding and exercisable	106,680	[6]
Contractual term	Nov. 15, 2023	[6]
February 25, 2019 [Member]
Class of Warrant or Right [Line Items]
Warrants outstanding	45,600	[7]
Exercise price per warrant | $ / shares	$ 7.187	[7]
Warrants outstanding and exercisable	45,600	[7]
Contractual term	Feb. 21, 2024	[7]
April 5, 2019 [Member]
Class of Warrant or Right [Line Items]
Warrants outstanding	408,457
Exercise price per warrant | $ / shares	$ 5.14
Warrants outstanding and exercisable	408,457
Contractual term	Oct. 07, 2024
April 5, 2019 One [Member]
Class of Warrant or Right [Line Items]
Warrants outstanding	49,015	[8]
Exercise price per warrant | $ / shares	$ 6.503	[8]
Warrants outstanding and exercisable	49,015	[8]
Contractual term	Apr. 03, 2024	[8]
June 5, 2019 and June 6, 2019 [Member]
Class of Warrant or Right [Line Items]
Warrants outstanding	1,464,665	[9]
Exercise price per warrant | $ / shares	$ 7.5	[9]
Warrants outstanding and exercisable	1,464,665	[9]
Contractual term	Jun. 05, 2024	[9]
June 5, 2019 [Member]
Class of Warrant or Right [Line Items]
Warrants outstanding	87,880	[10]
Exercise price per warrant | $ / shares	$ 9.375	[10]
Warrants outstanding and exercisable	87,880	[10]
Contractual term	Jun. 05, 2024	[10]
June 12, 2019 [Member]
Class of Warrant or Right [Line Items]
Warrants outstanding	416,667	[11]
Exercise price per warrant | $ / shares	$ 6	[11]
Warrants outstanding and exercisable	416,667	[11]
Contractual term	Dec. 12, 2024	[11]
June 10, 2019 [Member]
Class of Warrant or Right [Line Items]
Warrants outstanding	50,000	[12]
Exercise price per warrant | $ / shares	$ 7.5	[12]
Warrants outstanding and exercisable	50,000	[12]
Contractual term	Jun. 10, 2024	[12]

[1] Represents warrants for ordinary shares issuable upon an exercise price of $7.5 per share, which were granted on December 31, 2015 to Kreos Capital V (Expert) Fund Limited, or Kreos, in connection with a loan made by Kreos to us and are currently exercisable (in whole or in part) until the earlier of (i) December 30, 2025 or (ii) immediately prior to the consummation of a merger, consolidation, or reorganization of us with or into, or the sale or license of all or substantially all the assets or shares of us to, any other entity or person, other than a wholly-owned subsidiary of us, excluding any transaction in which our shareholders prior to the transaction will hold more than 50% of the voting and economic rights of the surviving entity after the transaction. None of these warrants had been exercised as of September 30, 2019.

[2] Represents warrants issued as part of our follow-on offering in November 2016. At any time, the board of directors may reduce the exercise price of the warrants to any amount and for any period of time it deems appropriate.

[3] Represents common warrants that were issued as part of the $8.0 million drawdown under the Loan Agreement which occurred on December 28, 2016. See footnote 1 for exercisability terms.

[4] Represents common warrants that were issued as part of our follow-on offering in November 2018. As of September 30, 2019, warrants to purchase an aggregate 1,651,537 ordinary shares had been exercised.

[5] Represents common warrants that were issued as part of our follow-on offering in November 2018. As of June 30, 2019, warrants to purchase an aggregate 1,651,537 ordinary shares had been exercised.

[6] Represents common warrants that were issued to the underwriters as compensation for their role in our follow-on offering in November 2018.

[7] Represents warrants that were issued to the exclusive placement agent as compensation for its role in our follow-on offering in February 2019.

[8] Represents warrants that were issued to the placement agent as compensation for its role in our April 2019 registered direct offering.

[9] Represents warrants that were issued to certain institutional investors in a warrant exercise agreement on June 5, 2019 and June 6, 2019, respectively.

[10] Represents warrants that were issued to the placement agent as compensation for its role in our June 2019 warrant exercise agreement and concurrent private placement of warrants.

[11] Represents warrants that were issued to certain institutional investors in a warrant exercise agreement in June 2019.

[12] Represents warrants that were issued to the placement agent as compensation for its role in our June 2019 registered direct offering and concurrent private placement of warrants.