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Research Collaboration Agreement and License Agreement (Details) - USD ($)
$ in Thousands
3 Months Ended 6 Months Ended
Jun. 30, 2019
Jun. 30, 2018
Jun. 30, 2019
Jun. 30, 2018
Research Collaboration Agreement and License Agreement (Textual)        
Research and development expenses $ 1,860 $ 1,897 $ 3,274 $ 4,048
License Agreement and Collaboration Agreement [Member]        
Research Collaboration Agreement and License Agreement (Textual)        
Total payment obligation     7,100  
Research and development expenses $ 868   $ 1,112  
Research collaboration agreement expire date     May 16, 2022