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Research Collaboration Agreement and License Agreement (Details) - USD ($)
$ in Thousands
12 Months Ended
Dec. 31, 2018
Dec. 31, 2017
Dec. 31, 2016
Research Collaboration Agreement and License Agreement (Textual)      
Research and development expenses $ 7,349 $ 6,042 $ 9,028
Harvard License Agreement and Collaboration Agreement [Member]      
Research Collaboration Agreement and License Agreement (Textual)      
Total payment obligation 6,500    
Research and development expenses $ 900    
Research collaboration agreement expire date May 16, 2021