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SHAREHOLDERS' EQUITY (Details 3)
6 Months Ended
Jun. 30, 2022
$ / shares
shares
Class of Warrant or Right [Line Items]  
Warrants outstanding 19,420,894
Warrants outstanding and exercisable 19,420,894
December 31, 2015 [Member]  
Class of Warrant or Right [Line Items]  
Warrants outstanding 4,771 [1]
Exercise price per warrant | $ / shares $ 7.5 [1]
Warrants outstanding and exercisable 4,771 [1]
December 28, 2016 [Member]  
Class of Warrant or Right [Line Items]  
Warrants outstanding 1,908 [2]
Exercise price per warrant | $ / shares $ 7.5 [2]
Warrants outstanding and exercisable 1,908 [2]
November 20, 2018 [Member]  
Class of Warrant or Right [Line Items]  
Warrants outstanding 126,839 [3]
Exercise price per warrant | $ / shares $ 7.5 [3]
Warrants outstanding and exercisable 126,839 [3]
Contractual term Nov. 20, 2023 [3]
November 20, 2018 One [Member]  
Class of Warrant or Right [Line Items]  
Warrants outstanding 106,680 [4]
Exercise price per warrant | $ / shares $ 9.375 [4]
Warrants outstanding and exercisable 106,680 [4]
Contractual term Nov. 15, 2023 [4]
February 25, 2019 [Member]  
Class of Warrant or Right [Line Items]  
Warrants outstanding 45,600 [5]
Exercise price per warrant | $ / shares $ 7.187 [5]
Warrants outstanding and exercisable 45,600 [5]
Contractual term Feb. 21, 2024 [5]
April 5, 2019 [Member]  
Class of Warrant or Right [Line Items]  
Warrants outstanding 408,457 [6]
Exercise price per warrant | $ / shares $ 5.14 [6]
Warrants outstanding and exercisable 408,457 [6]
Contractual term Oct. 07, 2024 [6]
April 5, 2019 One [Member]  
Class of Warrant or Right [Line Items]  
Warrants outstanding 49,015 [7]
Exercise price per warrant | $ / shares $ 6.503 [7]
Warrants outstanding and exercisable 49,015 [7]
Contractual term Apr. 03, 2024 [7]
June 5, 2019 and June 6, 2019 [Member]  
Class of Warrant or Right [Line Items]  
Warrants outstanding 1,464,665 [8]
Exercise price per warrant | $ / shares $ 7.5 [8]
Warrants outstanding and exercisable 1,464,665 [8]
Contractual term Jun. 05, 2024 [8]
June 5, 2019 [Member]  
Class of Warrant or Right [Line Items]  
Warrants outstanding 87,880 [9]
Exercise price per warrant | $ / shares $ 9.375 [9]
Warrants outstanding and exercisable 87,880 [9]
Contractual term Jun. 05, 2024 [9]
June 12, 2019 [Member]  
Class of Warrant or Right [Line Items]  
Warrants outstanding 416,667 [10]
Exercise price per warrant | $ / shares $ 6 [10]
Warrants outstanding and exercisable 416,667 [10]
Contractual term Dec. 12, 2024 [10]
June 10, 2019 [Member]  
Class of Warrant or Right [Line Items]  
Warrants outstanding 50,000 [11]
Exercise price per warrant | $ / shares $ 7.5 [11]
Warrants outstanding and exercisable 50,000 [11]
Contractual term Jun. 10, 2024 [11]
February 10, 2020 [Member]  
Class of Warrant or Right [Line Items]  
Warrants outstanding 28,400 [12]
Exercise price per warrant | $ / shares $ 1.25 [12]
Warrants outstanding and exercisable 28,400 [12]
Contractual term Feb. 10, 2025 [12]
February 10, 2020 One [Member]  
Class of Warrant or Right [Line Items]  
Warrants outstanding 105,840 [13]
Exercise price per warrant | $ / shares $ 1.563 [13]
Warrants outstanding and exercisable 105,840 [13]
Contractual term Feb. 10, 2025 [13]
July 6, 2020 [Member]  
Class of Warrant or Right [Line Items]  
Warrants outstanding 448,698 [14]
Exercise price per warrant | $ / shares $ 1.76 [14]
Warrants outstanding and exercisable 448,698 [14]
Contractual term Jan. 02, 2026 [14]
July 6, 2020 One [Member]  
Class of Warrant or Right [Line Items]  
Warrants outstanding 296,297 [15]
Exercise price per warrant | $ / shares $ 2.278 [15]
Warrants outstanding and exercisable 296,297 [15]
Contractual term Jan. 02, 2026 [15]
December 8, 2020 [Member]  
Class of Warrant or Right [Line Items]  
Warrants outstanding 586,760 [16]
Exercise price per warrant | $ / shares $ 1.34 [16]
Warrants outstanding and exercisable 586,760 [16]
Contractual term Jun. 08, 2026 [16]
December 8, 2020 [Member]  
Class of Warrant or Right [Line Items]  
Warrants outstanding 108,806 [17]
Exercise price per warrant | $ / shares $ 1.792 [17]
Warrants outstanding and exercisable 108,806 [17]
Contractual term Jun. 08, 2026 [17]
February 26, 2021 [Member]  
Class of Warrant or Right [Line Items]  
Warrants outstanding 5,460,751 [18]
Exercise price per warrant | $ / shares $ 3.6 [18]
Warrants outstanding and exercisable 5,460,751 [18]
Contractual term Aug. 26, 2026 [18]
February 26, 2021 One [Member]  
Class of Warrant or Right [Line Items]  
Warrants outstanding 655,290 [19]
Exercise price per warrant | $ / shares $ 4.578 [19]
Warrants outstanding and exercisable 655,290 [19]
Contractual term Aug. 26, 2026 [19]
September 29, 2021 [Member]  
Class of Warrant or Right [Line Items]  
Warrants outstanding 8,006,759 [20]
Exercise price per warrant | $ / shares $ 2 [20]
Warrants outstanding and exercisable 8,006,759 [20]
Contractual term Mar. 29, 2027 [20]
September 29, 2021 One [Member]  
Class of Warrant or Right [Line Items]  
Warrants outstanding 960,811 [21]
Exercise price per warrant | $ / shares $ 2.544 [21]
Warrants outstanding and exercisable 960,811 [21]
Contractual term Sep. 27, 2026 [21]
[1] Represents warrants for ordinary shares issuable upon an exercise price of $7.50 per share, which were granted on December 31, 2015 to Kreos Capital V (Expert) Fund Limited, or Kreos, in connection with a loan made by Kreos to us and are currently exercisable (in whole or in part) until the earlier of (i) December 30, 2025 or (ii) immediately prior to the consummation of a merger, consolidation, or reorganization of us with or into, or the sale or license of all or substantially all the assets or shares of us to, any other entity or person, other than a wholly-owned subsidiary of us, excluding any transaction in which the Company’s shareholders prior to the transaction will hold more than 50% of the voting and economic rights of the surviving entity after the transaction. None of these warrants had been exercised as of June 30, 2022.
[2] Represents common warrants that were issued as part of the $8.0 million drawdown under the Loan Agreement which occurred on December 28, 2016. See footnote 1 for exercisability terms.
[3] Represents common warrants that were issued as part of the Company’s follow-on public offering in November 2018.
[4] Represents common warrants that were issued to the underwriters as compensation for their role in the Company’s follow-on public offering in November 2018.
[5] Represents warrants that were issued to the exclusive placement agent as compensation for its role in the Company’s follow-on public offering in February 2019.
[6] Represents warrants that were issued to certain institutional purchasers in a private placement in the Company’s registered direct offering of ordinary shares in April 2019.
[7] Represents warrants that were issued to the placement agent as compensation for its role in the Company’s April 2019 registered direct offering.
[8] Represents warrants that were issued to certain institutional investors in a warrant exercise agreement on June 5, 2019, and June 6, 2019, respectively.
[9] Represents warrants that were issued to the placement agent as compensation for its role in the Company’s June 2019 warrant exercise agreement and concurrent private placement of warrants.
[10] Represents warrants that were issued to certain institutional investors in a warrant exercise agreement in June 2019.
[11] Represents warrants that were issued to the placement agent as compensation for its role in the Company’s June 2019 registered direct offering and concurrent private placement of warrants.
[12] Represents warrants that were issued to certain institutional purchasers in a private placement in the Company’s best efforts offering of ordinary shares in February 2020. During the year ended December 31, 2021, 3,740,100 warrants were exercised for total consideration of $4,675,125.
[13] Represents warrants that were issued to the placement agent as compensation for its role in the Company’s February 2020 best efforts offering. During the year ended December 31, 2021, 230,160 warrants were exercised for total consideration of $359,625.
[14] Represents warrants that were issued to certain institutional purchasers in a private placement in our registered direct offering of ordinary shares in July 2020. During the year ended December 31, 2021, 2,020,441 warrants were exercised for total consideration of $3,555,976.
[15] Represents warrants that were issued to the placement agent as compensation for its role in the Company’s July 2020 registered direct offering.
[16] Represents warrants that were issued to certain institutional purchasers in a private placement in our private placement offering of ordinary shares in December 2020. During the year ended December 31, 2021, 3,598,072 warrants were exercised for total consideration of $4,821,416.
[17] Represents warrants that were issued to the placement agent as compensation for its role in the Company’s December 2020 private placement. During the year ended December 31, 2021, 225,981 warrants were exercised for total consideration of $405,003.
[18] Represents warrants that were issued to certain institutional purchasers in a private placement in our private placement offering of ordinary shares in February 2021.
[19] Represents warrants that were issued to the placement agent as compensation for its role in the Company’s private placement offering in February 2021 (the “February 2021 Offering”).
[20] Represents warrants that were issued to certain institutional purchasers in a private placement in our registered direct offering of ordinary shares in September 2021.
[21] Represents warrants that were issued to the placement agent as compensation for its role in the Company’s September 2021 registered direct offering.