The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
3M CO COM 88579Y101 39,693 266,610 SH   DFND 1 266,610 0 0
ABBVIE INC COM 00287Y109 8,680 53,543 SH   DFND 1 53,543 0 0
AKARI THERAPEUTICS PLC SPONSORED ADR 00972G108 157 130,821 SH   DFND 1 130,821 0 0
ALDEYRA THERAPEUTICS INC COM 01438T106 89 20,020 SH   DFND 1 20,020 0 0
ALIBABA GROUP HOLDING LIMITED SPONSORED ADR 01609W102 235 2,160 SH   DFND 1 2,160 0 0
ALPHABET INC CLASS A CL A 38259P508 503 181 SH   DFND 1 181 0 0
ALPHABET INC CLASS C CL C 38259P706 19,551 7,000 SH   DFND 1 0 0 7,000
ALPINE IMMUNE SCIENCES INC COM 02083G100 112 12,445 SH   DFND 1 12,445 0 0
ALTRIA GROUP INC COM 02209S103 23,393 447,710 SH   DFND 1 447,710 0 0
AMETEK INC COM 031100100 1,855 13,930 SH   DFND 1 13,930 0 0
AMGEN INC COM 031162100 8,677 35,880 SH   DFND 1 35,880 0 0
ANAVEX LIFE SCIENCES CORP COM 032797300 1,054 85,585 SH   DFND 1 85,585 0 0
BANK OF AMERICA CORPORATION COM 060505104 1,749 42,440 SH   DFND 1 42,440 0 0
BANK OF NEW YORK MELLON CORP COM 064058100 30,692 618,420 SH   DFND 1 618,420 0 0
BECTON DICKINSON & CO COM 075887109 6,216 23,970 SH   DFND 1 23,970 0 0
BERKSHIRE HATHAWAY INC CLASS A CL A 084670108 414,145 783 SH   DFND 1 783 0 0
BERKSHIRE HATHAWAY INC CLASS B CL B 084670702 2,608 7,390 SH   DFND 1 7,390 0 0
BHP GROUP LIMITED SPONSORED ADR 088606108 11,387 147,400 SH   DFND 1 147,400 0 0
BOEING CO COM 097023105 4,692 24,500 SH   DFND 1 24,500 0 0
BRISTOL-MYERS SQUIBB COMPANY COM 110122108 2,723 37,280 SH   DFND 1 37,280 0 0
BRITISH AMERICAN TOBACCO PLC SPONSORED ADR 110448107 997 23,650 SH   DFND 1 23,650 0 0
CIGNA CORPORATION COM 125509109 5,487 22,899 SH   DFND 1 22,899 0 0
COCA COLA CO COM 191216100 3,001 48,400 SH   DFND 1 48,400 0 0
CORVUS PHARMACEUTICALS INC COM 221015100 82 49,959 SH   DFND 1 49,959 0 0
DANAHER CORP COM 235851102 54,316 185,170 SH   DFND 1 185,170 0 0
ECOLAB INC COM 278865100 565 3,200 SH   DFND 1 3,200 0 0
EXXON MOBIL CORPORATION COM 30231G102 24,718 299,290 SH   DFND 1 299,290 0 0
FORTIVE CORP COM 34959J108 4,305 70,650 SH   DFND 1 70,650 0 0
GILEAD SCIENCES INC COM 375558103 1,108 18,630 SH   DFND 1 18,630 0 0
HONEYWELL INTERNATIONAL INC COM 438516106 3,152 16,200 SH   DFND 1 16,200 0 0
IDEX CORPORATION COM 45167R104 399 2,080 SH   DFND 1 2,080 0 0
INTUITIVE SURGICAL INC COM 46120E602 14,906 49,410 SH   DFND 1 49,410 0 0
JACK HENRY & ASSOCIATES INC COM 426281101 3,659 18,570 SH   DFND 1 18,570 0 0
JOHNSON & JOHNSON COM 478160104 60,159 339,440 SH   DFND 1 339,440 0 0
THE KRAFT HEINZ COMPANY COM 500754106 236 6,000 SH   DFND 1 6,000 0 0
LINDE PUBLIC LIMITED COMPANY COM G5494J103 50,048 156,680 SH   DFND 1 156,680 0 0
LOCKHEED MARTIN CORP COM 539830109 3,240 7,340 SH   DFND 1 7,340 0 0
MASTERCARD INC CL A 57636Q104 3,574 10,000 SH   DFND 1 10,000 0 0
MEDTRONIC INC COM 585055106 8,772 79,060 SH   DFND 1 79,060 0 0
MERCK & CO INC COM 58933Y105 1,939 23,630 SH   DFND 1 23,630 0 0
METLIFE INC COM 59156R108 744 10,580 SH   DFND 1 10,580 0 0
MOODYS CORPORATION COM 20775CZK3 17,528 51,950 SH   DFND 1 51,950 0 0
NASDAQ INC COM 631103108 5,970 33,500 SH   DFND 1 33,500 0 0
NESTLE SA SPONSORED ADR 641069406 30,851 237,130 SH   DFND 1 237,130 0 0
NOVO NORDISK A/S SPONSORED ADR 670100205 12,982 116,900 SH   DFND 1 116,900 0 0
NUTRIEN LTD COM 67077M108 22,848 219,710 SH   DFND 1 219,710 0 0
OCULAR THERAPEUTIX INC COM 67576A100 84 17,000 SH   DFND 1 17,000 0 0
PARKER HANNIFIN CORPORATION COM 701094104 806 2,840 SH   DFND 1 2,840 0 0
PHILLIPS 66 COM 718546104 16,443 190,330 SH   DFND 1 190,330 0 0
PRUDENTIAL FINANCIAL INC COM 744320102 750 6,350 SH   DFND 1 6,350 0 0
ROCHE HOLDING AG COM 771195104 11,375 230,220 SH   DFND 1 230,220 0 0
ROPER TECHNOLOGIES INC COM 776696106 35,129 74,390 SH   DFND 1 74,390 0 0
SHELL PLC SPONSORED ADR 780259305 18,781 341,900 SH   DFND 1 341,900 0 0
STORE CAPITAL CORPORATION REIT 862121100 1,073 36,700 SH   DFND 1 36,700 0 0
UNION PACIFIC CORP COM 907818108 1,115 4,080 SH   DFND 1 4,080 0 0
US BANCORP COM 902973304 20,905 393,330 SH   DFND 1 393,330 0 0
VANGUARD FTSE EMERGING MARKETS ETF COM 922042858 2,713 58,810 SH   DFND 1 58,810 0 0
VANGUARD HEALTH CARE ETF ETF 92204A504 2,104 8,270 SH   DFND 1 8,270 0 0
VANGUARD HIGH DIVIDEND YIELD ETF ETF 921946406 273 2,430 SH   DFND 1 2,430 0 0
VANGUARD S&P 500 ETF ETF 922908363 7,971 19,200 SH   DFND 1 19,200 0 0
VEEVA SYSTEMS INC-CLASS A CL A 922475108 425 2,000 SH   DFND 1 2,000 0 0
VERIZON COMMUNICATIONS INC COM 92343V104 479 9,400 SH   DFND 1 9,400 0 0
VISA INC CLASS A CL A 92826C839 33,997 153,300 SH   DFND 1 153,300 0 0
VONTIER CORP COM 928881101 1,632 64,286 SH   DFND 1 64,286 0 0
WABTEC CORPORATION COM 929740108 6,878 71,523 SH   DFND 1 71,523 0 0
WATERS CORPORATION COM 941848103 14,461 46,590 SH   DFND 1 46,590 0 0
WELLS FARGO & CO COM 949746101 21,727 448,340 SH   DFND 1 448,340 0 0
XTRACKERS HARVEST CSI 300 CHINA A-SHARES ETF ETF 233051879 387 11,700 SH   DFND 1 11,700 0 0