The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
3M CO COM 88579Y101 47,154 265,460 SH   DFND 1 265,460 0 0
ABBVIE INC COM 00287Y109 7,164 52,913 SH   DFND 1 52,913 0 0
AKARI THERAPEUTICS PLC SPONSORED ADR 00972G108 135 89,815 SH   DFND 1 89,815 0 0
ALDEYRA THERAPEUTICS INC COM 01438T106 80 20,020 SH   DFND 1 20,020 0 0
ALPHABET INC CLASS A CL A 38259P508 524 181 SH   DFND 1 181 0 0
ALPHABET INC CLASS C CL C 38259P706 20,255 7,000 SH   DFND 1 0 0 7,000
ALPINE IMMUNE SCIENCES INC COM 02083G100 145 10,445 SH   DFND 1 10,445 0 0
ALTRIA GROUP INC COM 02209S103 21,136 446,010 SH   DFND 1 446,010 0 0
AMETEK INC COM 031100100 2,048 13,930 SH   DFND 1 13,930 0 0
AMGEN INC COM 031162100 7,901 35,120 SH   DFND 1 35,120 0 0
ANAVEX LIFE SCIENCES CORP COM 032797300 1,484 85,585 SH   DFND 1 85,585 0 0
BANK OF AMERICA CORPORATION COM 060505104 1,990 44,740 SH   DFND 1 44,740 0 0
BANK OF NEW YORK MELLON CORP COM 064058100 38,311 659,620 SH   DFND 1 659,620 0 0
BECTON DICKINSON & CO COM 075887109 6,028 23,970 SH   DFND 1 23,970 0 0
BERKSHIRE HATHAWAY INC CLASS A CL A 084670108 352,868 783 SH   DFND 1 783 0 0
BERKSHIRE HATHAWAY INC CLASS B CL B 084670702 2,210 7,390 SH   DFND 1 7,390 0 0
BHP BILLITON PLC SPONSORED ADR 05545E209 8,810 147,400 SH   DFND 1 147,400 0 0
BIODELIVERY SCIENCES INTERNATIONAL INC COM 09060J106 78 25,000 SH   DFND 1 25,000 0 0
BOEING CO COM 097023105 4,932 24,500 SH   DFND 1 24,500 0 0
BRISTOL-MYERS SQUIBB COMPANY COM 110122108 2,324 37,280 SH   DFND 1 37,280 0 0
BRITISH AMERICAN TOBACCO PLC SPONSORED ADR 110448107 885 23,650 SH   DFND 1 23,650 0 0
CIGNA CORPORATION COM 125509109 5,258 22,899 SH   DFND 1 22,899 0 0
CISCO SYSTEMS INC COM 17275R102 2,250 35,500 SH   DFND 1 35,500 0 0
COCA COLA CO COM 191216100 2,866 48,400 SH   DFND 1 48,400 0 0
CORVUS PHARMACEUTICALS INC COM 221015100 48 19,959 SH   DFND 1 19,959 0 0
DANAHER CORP COM 235851102 62,798 190,870 SH   DFND 1 190,870 0 0
ECOLAB INC COM 278865100 493 2,100 SH   DFND 1 2,100 0 0
EXXON MOBIL CORPORATION COM 30231G102 18,244 298,150 SH   DFND 1 298,150 0 0
FORTIVE CORP COM 34959J108 5,390 70,650 SH   DFND 1 70,650 0 0
GILEAD SCIENCES INC COM 375558103 1,353 18,630 SH   DFND 1 18,630 0 0
HONEYWELL INTERNATIONAL INC COM 438516106 3,378 16,200 SH   DFND 1 16,200 0 0
INTUITIVE SURGICAL INC COM 46120E602 18,723 52,110 SH   DFND 1 52,110 0 0
JACK HENRY & ASSOCIATES INC COM 426281101 3,101 18,570 SH   DFND 1 18,570 0 0
JOHNSON & JOHNSON COM 478160104 58,068 339,440 SH   DFND 1 339,440 0 0
THE KRAFT HEINZ COMPANY COM 500754106 508 14,150 SH   DFND 1 14,150 0 0
LINDE PUBLIC LIMITED COMPANY COM G5494J103 54,279 156,680 SH   DFND 1 156,680 0 0
LOCKHEED MARTIN CORP COM 539830109 2,531 7,120 SH   DFND 1 7,120 0 0
MASTERCARD INC CL A 57636Q104 3,593 10,000 SH   DFND 1 10,000 0 0
MEDTRONIC INC COM 585055106 8,179 79,060 SH   DFND 1 79,060 0 0
MERCK & CO INC COM 58933Y105 1,724 22,500 SH   DFND 1 22,500 0 0
METLIFE INC COM 59156R108 661 10,580 SH   DFND 1 10,580 0 0
MOODYS CORPORATION COM 20775CZK3 20,291 51,950 SH   DFND 1 51,950 0 0
NASDAQ INC COM 631103108 7,035 33,500 SH   DFND 1 33,500 0 0
NESTLE SA SPONSORED ADR 641069406 33,286 237,130 SH   DFND 1 237,130 0 0
NOVO NORDISK A/S SPONSORED ADR 670100205 13,093 116,900 SH   DFND 1 116,900 0 0
NUTRIEN LTD COM 67077M108 18,342 243,910 SH   DFND 1 243,910 0 0
OCULAR THERAPEUTIX INC COM 67576A100 84 12,000 SH   DFND 1 12,000 0 0
PARKER HANNIFIN CORPORATION COM 701094104 903 2,840 SH   DFND 1 2,840 0 0
PHILLIPS 66 COM 718546104 13,791 190,330 SH   DFND 1 190,330 0 0
PRUDENTIAL FINANCIAL INC COM 744320102 687 6,350 SH   DFND 1 6,350 0 0
ROCHE HOLDING AG COM 771195104 11,900 230,220 SH   DFND 1 230,220 0 0
ROPER TECHNOLOGIES INC COM 776696106 36,589 74,390 SH   DFND 1 74,390 0 0
ROYAL DUTCH SHELL PLC CLASS B COM 780259107 14,787 341,100 SH   DFND 1 341,100 0 0
STORE CAPITAL CORPORATION REIT 862121100 1,262 36,700 SH   DFND 1 36,700 0 0
UNION PACIFIC CORP COM 907818108 1,028 4,080 SH   DFND 1 4,080 0 0
US BANCORP COM 902973304 22,093 393,330 SH   DFND 1 393,330 0 0
VANGUARD FTSE EMERGING MARKETS ETF COM 922042858 2,909 58,810 SH   DFND 1 58,810 0 0
VANGUARD HEALTH CARE ETF ETF 92204A504 1,921 7,210 SH   DFND 1 7,210 0 0
VANGUARD S&P 500 ETF ETF 922908363 8,382 19,200 SH   DFND 1 19,200 0 0
VEEVA SYSTEMS INC-CLASS A CL A 922475108 511 2,000 SH   DFND 1 2,000 0 0
VERIZON COMMUNICATIONS INC COM 92343V104 488 9,400 SH   DFND 1 9,400 0 0
VISA INC CLASS A CL A 92826C839 33,222 153,300 SH   DFND 1 153,300 0 0
VONTIER CORP COM 928881101 1,724 56,086 SH   DFND 1 56,086 0 0
WABTEC CORPORATION COM 929740108 6,588 71,523 SH   DFND 1 71,523 0 0
WATERS CORPORATION COM 941848103 17,359 46,590 SH   DFND 1 46,590 0 0
WELLS FARGO & CO COM 949746101 21,511 448,340 SH   DFND 1 448,340 0 0
XTRACKERS HARVEST CSI 300 CHINA A-SHARES ETF ETF 233051879 457 11,700 SH   DFND 1 11,700 0 0