The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
3M CO COM 88579Y101 40,869 262,000 SH   DFND 1 262,000 0 0
ABBVIE INC COM 00287Y109 893 9,093 SH   DFND 1 9,093 0 0
AKARI THERAPEUTICS PLC COM 00972G108 3,270 1,500,096 SH   DFND 1 1,500,096 0 0
ALDEYRA THERAPEUTICS INC COM 01438T106 167 40,020 SH   DFND 1 40,020 0 0
ALPHABET INC CLASS A CL A 38259P508 328 231 SH   DFND 1 231 0 0
ALPHABET INC CLASS C CL C 38259P706 9,895 7,000 SH   DFND 1 0 0 7,000
ALPINE IMMUNE SCIENCES INC COM 02083G100 490 50,445 SH   DFND 1 50,445 0 0
ALTRIA GROUP INC COM 02209S103 12,556 319,890 SH   DFND 1 319,890 0 0
AMGEN INC COM 031162100 7,694 32,620 SH   DFND 1 32,620 0 0
ANAVEX LIFE SCIENCES CORP COM 032797300 490 99,578 SH   DFND 1 99,578 0 0
ANHEUSER-BUSCH INBEV NV SPONSORED ADR 03524A108 5,569 112,960 SH   DFND 1 112,960 0 0
BANK OF NEW YORK MELLON CORP COM 064058100 17,710 458,210 SH   DFND 1 458,210 0 0
BECTON DICKINSON & CO COM 075887109 5,735 23,970 SH   DFND 1 23,970 0 0
BERKSHIRE HATHAWAY INC CLASS A CL A 084670108 209,296 783 SH   DFND 1 783 0 0
BERKSHIRE HATHAWAY INC CLASS B CL B 084670702 1,319 7,390 SH   DFND 1 7,390 0 0
BHP BILLITON PLC ADR 05545E209 6,670 162,100 SH   DFND 1 162,100 0 0
BOEING CO COM 097023105 6,141 33,500 SH   DFND 1 33,500 0 0
BRITISH AMERICAN TOBACCO PLC COM 110448107 918 23,650 SH   DFND 1 23,650 0 0
CHINA MOBILE LIMITED SPONSORED ADR 16941M109 1,625 48,300 SH   DFND 1 48,300 0 0
CIGNA CORPORATION COM 125509109 4,297 22,899 SH   DFND 1 22,899 0 0
CISCO SYSTEMS INC COM 17275R102 2,075 44,500 SH   DFND 1 44,500 0 0
COCA COLA CO COM 191216100 2,163 48,400 SH   DFND 1 48,400 0 0
CORVUS PHARMACEUTICALS INC COM 221015100 166 60,959 SH   DFND 1 60,959 0 0
DANAHER CORP COM 235851102 33,357 188,640 SH   DFND 1 188,640 0 0
ECOLAB INC COM 278865100 418 2,100 SH   DFND 1 2,100 0 0
EXXON MOBIL CORPORATION COM 30231G102 12,090 270,350 SH   DFND 1 270,350 0 0
FORTIVE CORP COM 34959J108 4,346 64,240 SH   DFND 1 64,240 0 0
GENERAL ELECTRIC COMPANY COM 369604103 343 50,280 SH   DFND 1 50,280 0 0
GILEAD SCIENCES INC COM 375558103 1,433 18,630 SH   DFND 1 18,630 0 0
HONEYWELL INTERNATIONAL INC COM 438516106 2,342 16,200 SH   DFND 1 16,200 0 0
INTERNATIONAL BUSINESS MACHINES CORP COM 459200101 400 3,310 SH   DFND 1 3,310 0 0
INTUITIVE SURGICAL INC COM 46120E602 10,627 18,650 SH   DFND 1 18,650 0 0
JACK HENRY & ASSOCIATES INC COM 426281101 2,521 13,700 SH   DFND 1 13,700 0 0
JOHNSON & JOHNSON COM 478160104 47,276 336,170 SH   DFND 1 336,170 0 0
THE KRAFT HEINZ COMPANY COM 500754106 1,185 37,150 SH   DFND 1 37,150 0 0
LINDE PUBLIC LIMITED COMPANY COM G5494J103 33,233 156,680 SH   DFND 1 156,680 0 0
LOCKHEED MARTIN CORP COM 539830109 2,259 6,190 SH   DFND 1 6,190 0 0
MASTERCARD INC CL A 57636Q104 2,957 10,000 SH   DFND 1 10,000 0 0
MEDTRONIC INC COM 585055106 7,993 87,160 SH   DFND 1 87,160 0 0
MOODYS CORPORATION COM 20775CZK3 14,272 51,950 SH   DFND 1 51,950 0 0
NASDAQ INC COM 631103108 4,002 33,500 SH   DFND 1 33,500 0 0
NESTLE SA SPONSORED ADR 641069406 26,189 237,130 SH   DFND 1 237,130 0 0
NOVO NORDISK A/S SPONSORED ADR 670100205 7,655 116,900 SH   DFND 1 116,900 0 0
NUTRIEN LTD COM 67077M108 11,560 360,110 SH   DFND 1 360,110 0 0
OMNICOM GROUP INC COM 681919106 300 5,500 SH   DFND 1 5,500 0 0
PHILLIPS 66 COM 718546104 11,877 165,190 SH   DFND 1 165,190 0 0
ROCHE HOLDING AG SPONSORED ADR 771195104 9,644 222,320 SH   DFND 1 222,320 0 0
ROPER TECHNOLOGIES INC COM 776696106 27,411 70,600 SH   DFND 1 70,600 0 0
ROYAL DUTCH SHELL PLC CLASS B CL B 780259107 9,083 298,280 SH   DFND 1 298,280 0 0
STORE CAPITAL CORPORATION REIT 862121100 874 36,700 SH   DFND 1 36,700 0 0
TG THERAPEUTICS INC COM 88322Q108 195 10,000 SH   DFND 1 10,000 0 0
UNION PACIFIC CORP COM 907818108 690 4,080 SH   DFND 1 4,080 0 0
US BANCORP COM 902973304 6,258 169,970 SH   DFND 1 169,970 0 0
VANGUARD FTSE EMERGING MARKETS ETF ETF 922042858 2,329 58,810 SH   DFND 1 58,810 0 0
VANGUARD S&P 500 ETF ETF 922908363 5,003 17,650 SH   DFND 1 17,650 0 0
VISA INC CLASS A CL A 92826C839 29,613 153,300 SH   DFND 1 153,300 0 0
WABTEC CORPORATION COM 929740108 4,257 73,943 SH   DFND 1 73,943 0 0
WATERS CORPORATION COM 941848103 8,410 46,620 SH   DFND 1 46,620 0 0
WELLS FARGO & CO COM 949746101 46,127 1,801,830 SH   DFND 1 1,801,830 0 0
VEEVA SYSTEMS INC-CLASS A CL A 922475108 469 2,000 SH   DFND 1 2,000 0 0