The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
3M CO COM 88579Y101 33,749 247,230 SH   DFND 1 247,230 0 0
AKARI THERAPEUTICS PLC COM 00972G108 2,175 1,500,096 SH   DFND 1 1,500,096 0 0
ALDEYRA THERAPEUTICS INC COM 01438T106 148 60,020 SH   DFND 1 60,020 0 0
ALLERGAN PLC SPONSORED ADR G0177J108 1,953 11,030 SH   DFND 1 11,030 0 0
ALPHABET INC CLASS A CL A 38259P508 268 231 SH   DFND 1 231 0 0
ALPHABET INC CLASS C CL C 38259P706 7,721 6,640 SH   DFND 1 0 0 6,640
ALPINE IMMUNE SCIENCES INC COM 02083G100 483 167,588 SH   DFND 1 167,588 0 0
ALTRIA GROUP INC COM 02209S103 12,504 323,360 SH   DFND 1 323,360 0 0
AMERISOURCEBERGEN CORP COM 03073E105 229 2,590 SH   DFND 1 2,590 0 0
AMGEN INC COM 031162100 6,822 33,650 SH   DFND 1 33,650 0 0
ANAVEX LIFE SCIENCES CORP COM 032797300 314 99,578 SH   DFND 1 99,578 0 0
ANHEUSER-BUSCH INBEV NV SPONSORED ADR 03524A108 4,896 110,960 SH   DFND 1 110,960 0 0
APPLIED MATERIALS INC COM 038222105 212 4,630 SH   DFND 1 4,630 0 0
BANK OF NEW YORK MELLON CORP COM 064058100 14,971 444,510 SH   DFND 1 444,510 0 0
BECTON DICKINSON & CO COM 075887109 5,508 23,970 SH   DFND 1 23,970 0 0
BERKSHIRE HATHAWAY INC CLASS A CL A 084670108 212,976 783 SH   DFND 1 783 0 0
BERKSHIRE HATHAWAY INC CLASS B CL B 084670702 980 5,360 SH   DFND 1 5,360 0 0
BHP BILLITON PLC COM 05545E209 4,918 162,100 SH   DFND 1 162,100 0 0
BIOGEN INC COM 09062X103 269 850 SH   DFND 1 850 0 0
BOEING CO COM 097023105 8,635 57,900 SH   DFND 1 57,900 0 0
BRITISH AMERICAN TOBACCO PLC COM 110448107 809 23,650 SH   DFND 1 23,650 0 0
CHINA MOBILE LIMITED SPONSORED ADR 16941M109 1,819 48,300 SH   DFND 1 48,300 0 0
CIGNA CORPORATION COM 125509109 4,663 26,316 SH   DFND 1 26,316 0 0
CISCO SYSTEMS INC COM 17275R102 1,749 44,500 SH   DFND 1 44,500 0 0
COCA COLA CO COM 191216100 2,142 48,400 SH   DFND 1 48,400 0 0
CORCEPT THERAPEUTICS INC COM 218352102 200 16,790 SH   DFND 1 16,790 0 0
CORVUS PHARMACEUTICALS INC COM 221015100 129 60,959 SH   DFND 1 60,959 0 0
DANAHER CORP COM 235851102 29,869 215,800 SH   DFND 1 215,800 0 0
DEREXION DAILY CSI 300 CH INA A SHARE BEAR 1X SHARES ETF 25459Y116 478 16,000 SH   DFND 1 16,000 0 0
DIAMOND OFFSHORE DRILLING INC COM 25271C102 64 35,200 SH   DFND 1 35,200 0 0
ECOLAB INC COM 278865100 327 2,100 SH   DFND 1 2,100 0 0
EXXON MOBIL CORPORATION COM 30231G102 9,589 252,550 SH   DFND 1 252,550 0 0
FORTIVE CORP COM 34959J108 3,545 64,240 SH   DFND 1 64,240 0 0
FTS INTERNATIONAL INC COM 30283W104 4 18,640 SH   DFND 1 18,640 0 0
GAMESTOP CORP-CLASS A CL A 36467W109 77 22,120 SH   DFND 1 22,120 0 0
GENERAL ELECTRIC COMPANY COM 369604103 399 50,280 SH   DFND 1 50,280 0 0
GILEAD SCIENCES INC COM 375558103 1,619 21,650 SH   DFND 1 21,650 0 0
GRAFTECH INTERNATIONAL LTD COM 384313508 115 14,150 SH   DFND 1 14,150 0 0
HONEYWELL INTERNATIONAL INC COM 438516106 1,191 8,900 SH   DFND 1 8,900 0 0
INNOVIVA INC COM 45781M101 169 14,340 SH   DFND 1 14,340 0 0
INTERNATIONAL BUSINESS MACHINES CORP COM 459200101 367 3,310 SH   DFND 1 3,310 0 0
INTUITIVE SURGICAL INC COM 46120E602 9,236 18,650 SH   DFND 1 18,650 0 0
JACK HENRY & ASSOCIATES INC COM 426281101 2,127 13,700 SH   DFND 1 13,700 0 0
JOHNSON & JOHNSON COM 478160104 44,082 336,170 SH   DFND 1 336,170 0 0
KLA-TENCOR CORP COM 482480100 231 1,610 SH   DFND 1 1,610 0 0
THE KRAFT HEINZ COMPANY COM 500754106 919 37,150 SH   DFND 1 37,150 0 0
LAM RESEARCH CORP COM 512807108 245 1,020 SH   DFND 1 1,020 0 0
LINDE PUBLIC LIMITED COMPANY COM G5494J103 26,126 151,020 SH   DFND 1 151,020 0 0
LOCKHEED MARTIN CORP COM 539830109 1,657 4,890 SH   DFND 1 4,890 0 0
MASTERCARD INC CL A 57636Q104 2,416 10,000 SH   DFND 1 10,000 0 0
MEDTRONIC INC COM 585055106 7,525 83,440 SH   DFND 1 83,440 0 0
THE MICHAELS COS INC COM 59408Q106 25 15,450 SH   DFND 1 15,450 0 0
MOODYS CORPORATION COM 20775CZK3 10,987 51,950 SH   DFND 1 51,950 0 0
NASDAQ INC COM 631103108 2,713 28,570 SH   DFND 1 28,570 0 0
NESTLE SA SPONSORED ADR 641069406 24,422 237,130 SH   DFND 1 237,130 0 0
NIC INC COM 62914B100 267 11,620 SH   DFND 1 11,620 0 0
NOVO NORDISK A/S SPONSORED ADR 670100205 7,037 116,900 SH   DFND 1 116,900 0 0
NUTRIEN LTD COM 67077M108 12,222 360,110 SH   DFND 1 360,110 0 0
OMNICOM GROUP INC COM 681919106 443 8,070 SH   DFND 1 8,070 0 0
PHILLIPS 66 COM 718546104 12,216 227,690 SH   DFND 1 227,690 0 0
PRESTIGE CONSUMER HEALTHCARE COM 74112D101 255 6,960 SH   DFND 1 6,960 0 0
PROSHARES SHORT VIX ST FUTUR ETF 74347W130 443 14,300 SH   DFND 1 14,300 0 0
ROCHE HOLDING AG SPONSORED ADR 771195104 9,020 222,320 SH   DFND 1 222,320 0 0
ROPER TECHNOLOGIES INC COM 776696106 22,014 70,600 SH   DFND 1 70,600 0 0
ROYAL DUTCH SHELL PLC CLASS B CL B 780259107 9,611 294,280 SH   DFND 1 294,280 0 0
SOPHIRIS BIO INC COM 83578Q209 70 257,480 SH   DFND 1 257,480 0 0
SPDR PORT SHRT TRM TRSRY ETF 78468R101 9,508 309,500 SH   DFND 1 309,500 0 0
STAMPS.COM INC COM 852857200 336 2,580 SH   DFND 1 2,580 0 0
STEMLINE THERAPEUTICS INC COM 85858C107 97 20,000 SH   DFND 1 20,000 0 0
STERICYCLE INC COM 858912108 248 5,100 SH   DFND 1 5,100 0 0
STORE CAPITAL CORPORATION REIT 862121100 665 36,700 SH   DFND 1 36,700 0 0
TEGNA INC COM 87901J105 132 12,180 SH   DFND 1 12,180 0 0
TG THERAPEUTICS INC COM 88322Q108 98 10,000 SH   DFND 1 10,000 0 0
UNION PACIFIC CORP COM 907818108 575 4,080 SH   DFND 1 4,080 0 0
US BANCORP COM 902973304 4,550 132,070 SH   DFND 1 132,070 0 0
VANGUARD S&P 500 ETF ETF 922908363 4,180 17,650 SH   DFND 1 17,650 0 0
VANGUARD SHORT-TERM BOND ETF ETF 921937827 9,418 114,600 SH   DFND 1 114,600 0 0
VECTOR GROUP LTD COM 92240M108 187 19,834 SH   DFND 1 19,834 0 0
VISA INC CLASS A CL A 92826C839 24,700 153,300 SH   DFND 1 153,300 0 0
WABTEC CORPORATION COM 929740108 7,265 150,950 SH   DFND 1 150,950 0 0
WATERS CORPORATION COM 941848103 8,487 46,620 SH   DFND 1 46,620 0 0
WEIGHT WATCHERS INTL INC COM 948626106 179 10,600 SH   DFND 1 10,600 0 0
WELLS FARGO & CO COM 949746101 51,118 1,781,130 SH   DFND 1 1,781,130 0 0
VEEVA SYSTEMS INC-CLASS A CL A 922475108 313 2,000 SH   DFND 1 2,000 0 0
ZAFGEN INC COM 98885E103 116 150,000 SH   DFND 1 150,000 0 0