The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
3M CO COM 88579Y101 38,716 186,330 SH   DFND 1 186,330 0 0
ACADIA PHARMACEUTICALS INC COM 004225108 537 20,000 SH   DFND 1 20,000 0 0
AKARI THERAPEUTICS PLC COM 00972G108 5,120 1,430,096 SH   DFND 1 1,430,096 0 0
ALDEYRA THERAPEUTICS INC COM 01438T106 402 44,520 SH   DFND 1 44,520 0 0
ALLERGAN PLC SPONSORED ADR G0177J108 27,267 186,240 SH   DFND 1 186,240 0 0
ALLISON TRANSMISSION HOLDINGS,INC COM 01973R101 279 6,220 SH   DFND 1 6,220 0 0
ALPHABET INC CLASS C CL C 38259P706 4,576 3,900 SH   DFND 1 0 0 3,900
ALPINE IMMUNE SCIENCES INC COM 02083G100 844 122,972 SH   DFND 1 122,972 0 0
ALTRIA GROUP INC COM 02209S103 8,338 145,190 SH   DFND 1 145,190 0 0
AMC NETWORKS INC COM 00164V103 288 5,080 SH   DFND 1 5,080 0 0
AMGEN INC COM 031162100 6,484 34,130 SH   DFND 1 34,130 0 0
ANAVEX LIFE SCIENCES CORP COM 032797300 531 174,080 SH   DFND 1 174,080 0 0
ANHEUSER-BUSCH INBEV NV SPONSORED ADR 03524A108 10,395 123,800 SH   DFND 1 123,800 0 0
ANTHEM INC COM 036752103 327 1,140 SH   DFND 1 1,140 0 0
AT&T INC COM 00206R102 3,048 97,200 SH   DFND 1 97,200 0 0
AUTOHOME INC SPONSORED ADR 05278C107 281 2,670 SH   DFND 1 2,670 0 0
AVEO PHARMACEUTICALS INC COM 053588109 66 80,000 SH   DFND 1 80,000 0 0
BANK OF NEW YORK MELLON CORP COM 064058100 15,137 300,160 SH   DFND 1 300,160 0 0
BECTON DICKINSON & CO COM 075887109 5,694 22,800 SH   DFND 1 22,800 0 0
BERKSHIRE HATHAWAY INC CLASS A CL A 084670108 223,803 743 SH   DFND 1 743 0 0
BERKSHIRE HATHAWAY INC CLASS B CL B 084670702 482 2,400 SH   DFND 1 2,400 0 0
BHP BILLITON PLC COM 05545E209 11,260 233,230 SH   DFND 1 233,230 0 0
BIOGEN INC COM 09062X103 3,371 14,260 SH   DFND 1 14,260 0 0
BOEING CO COM 097023105 22,084 57,900 SH   DFND 1 57,900 0 0
BRIGHT SCHOLAR EDUCATION HOLDINGS LTD SPONSORED ADR 109199109 167 16,140 SH   DFND 1 16,140 0 0
BRISTOL-MYERS SQUIBB CO COM 110122108 2,962 62,080 SH   DFND 1 62,080 0 0
BRITISH AMERICAN TOBACCO PLC COM 110448107 807 19,350 SH   DFND 1 19,350 0 0
THE BUCKLE, INC COM 118440106 213 11,400 SH   DFND 1 11,400 0 0
CALITHERA BIOSCIENCES,INC COM 13089P101 337 50,000 SH   DFND 1 50,000 0 0
CANNAE HOLDINGS INC COM 13765N107 325 13,400 SH   DFND 1 13,400 0 0
CELGENE CORP COM 151020104 3,337 35,370 SH   DFND 1 35,370 0 0
CHECK POINT SOFTWARE TECHNOLOGIES LTD COM M22465104 317 2,510 SH   DFND 1 2,510 0 0
CHINA MOBILE LIMITED SPONSORED ADR 16941M109 2,463 48,300 SH   DFND 1 48,300 0 0
CIGNA CORPORATION COM 125509109 4,615 28,697 SH   DFND 1 28,697 0 0
CIRRUS LOGIC, INC COM 172755100 275 6,530 SH   DFND 1 6,530 0 0
CISCO SYSTEMS INC COM 17275R102 5,610 103,900 SH   DFND 1 103,900 0 0
COCA COLA CO COM 191216100 2,156 46,000 SH   DFND 1 46,000 0 0
COLGATE-PALMOLIVE COMPANY COM 194162103 9,739 142,090 SH   DFND 1 142,090 0 0
CONATUS PHARMACEUTICALS INC COM 20600T108 217 200,488 SH   DFND 1 200,488 0 0
CORVUS PHARMACEUTICALS INC COM 221015100 523 130,000 SH   DFND 1 130,000 0 0
DANAHER CORP COM 235851102 28,490 215,800 SH   DFND 1 215,800 0 0
DAVITA HEALTHCARE PARTNERS INC COM 23918K108 4,065 74,880 SH   DFND 1 74,880 0 0
DEUTSCHE X-TRACKERS HARVEST CSI 300 CHINA A-SHARES FUND ETF 233051879 7,091 246,800 SH   DFND 1 246,800 0 0
DIAMOND OFFSHORE DRILLING INC COM 25271C102 369 35,200 SH   DFND 1 35,200 0 0
DYNAVAX TECHNOLOGIES CORPORATION COM 268158201 772 105,573 SH   DFND 1 105,573 0 0
ECOLAB INC COM 278865100 371 2,100 SH   DFND 1 2,100 0 0
EQUIFAX INC COM 294429AN5 331 2,790 SH   DFND 1 2,790 0 0
EXXON MOBIL CORPORATION COM 30231G102 11,175 138,303 SH   DFND 1 138,303 0 0
F5 NETWORKS, INC COM 315616102 261 1,660 SH   DFND 1 1,660 0 0
FORTIVE CORP COM 34959J108 11,887 141,700 SH   DFND 1 141,700 0 0
GENERAL ELECTRIC COMPANY COM 369604103 20,830 2,085,100 SH   DFND 1 2,085,100 0 0
GENERAL MILLS,INC COM 370334104 14,769 285,400 SH   DFND 1 285,400 0 0
GILEAD SCIENCES INC COM 375558103 5,503 84,650 SH   DFND 1 84,650 0 0
GRAY TELEVISION, INC COM 389375106 468 21,890 SH   DFND 1 21,890 0 0
H&R BLOCK, INC COM 093671105 234 9,760 SH   DFND 1 9,760 0 0
HOLOGIC, INC COM 436440101 332 6,850 SH   DFND 1 6,850 0 0
HOSTESS BRANDS,INC COM 44109J106 223 17,810 SH   DFND 1 17,810 0 0
HOULIHAN LOKEY, INC COM 441593100 263 5,740 SH   DFND 1 5,740 0 0
INTERDIGITAL INC COM 45867G101 216 3,270 SH   DFND 1 3,270 0 0
INTERNATIONAL BUSINESS MACHINES CORP COM 459200101 20,362 144,310 SH   DFND 1 144,310 0 0
INTUITIVE SURGICAL INC COM 46120E602 10,641 18,650 SH   DFND 1 18,650 0 0
ISHARES CORE HIGH DIVIDEND ETF ETF 46429B663 2,279 24,430 SH   DFND 1 24,430 0 0
ISHARES MSCI RUSSIA ETF ETF 46434G798 271 7,850 SH   DFND 1 7,850 0 0
ISHARES MSCI SOUTH KOREA ETF ETF 464286772 430 7,050 SH   DFND 1 7,050 0 0
ISHARES NASDAQ BIOTECHNOLOGY ETF 464287556 3,180 28,440 SH   DFND 1 28,440 0 0
JACK HENRY & ASSOCIATES INC COM 426281101 1,901 13,700 SH   DFND 1 13,700 0 0
JOHNSON & JOHNSON COM 478160104 40,673 290,960 SH   DFND 1 290,960 0 0
KBR, INC COM 48242W106 287 15,040 SH   DFND 1 15,040 0 0
KLA-TENCOR CORPORATION COM 482480100 283 2,370 SH   DFND 1 2,370 0 0
THE KRAFT HEINZ COMPANY COM 500754106 704 21,550 SH   DFND 1 21,550 0 0
LINDE PUBLIC LIMITED COMPANY COM G5494J103 26,569 151,020 SH   DFND 1 151,020 0 0
MASTERCARD INC CL A 57636Q104 2,355 10,000 SH   DFND 1 10,000 0 0
MC DERMOTT INTERNATIONAL,INC COM 580037703 562 75,600 SH   DFND 1 75,600 0 0
MEDTRONIC INC COM 585055106 4,618 50,700 SH   DFND 1 50,700 0 0
MERSANA THERAPEUTICS INC COM 59045L106 475 90,246 SH   DFND 1 90,246 0 0
THE MICHAELS COS INC COM 59408Q106 161 14,120 SH   DFND 1 14,120 0 0
MOODYS CORPORATION COM 20775CZK3 9,317 51,450 SH   DFND 1 51,450 0 0
MSG NETWORKS INC COM 553573106 251 11,540 SH   DFND 1 11,540 0 0
NATIONAL OILWELL VARCO INC COM 637071101 1,169 43,900 SH   DFND 1 43,900 0 0
NESTLE SA SPONSORED ADR 641069406 21,650 227,130 SH   DFND 1 227,130 0 0
NOVO NORDISK A/S SPONSORED ADR 670100205 12,988 248,290 SH   DFND 1 248,290 0 0
NOW INC COM 67011P100 777 55,675 SH   DFND 1 55,675 0 0
NUTRIEN LTD COM 67077M108 17,216 326,310 SH   DFND 1 326,310 0 0
OMNICOM GROUP INC COM 681919106 401 5,500 SH   DFND 1 5,500 0 0
ONESMART INTERNATIONAL EDUCATION GROUP LIMITED SPONSORED ADR 68276W103 189 23,940 SH   DFND 1 23,940 0 0
ORACLE CORPORATION COM 68389X105 301 5,600 SH   DFND 1 5,600 0 0
PACCAR INC COM 693718108 253 3,710 SH   DFND 1 3,710 0 0
PHILLIPS 66 COM 718546104 14,425 151,570 SH   DFND 1 151,570 0 0
PREMIER, INC COM 74051N102 283 8,200 SH   DFND 1 8,200 0 0
PROTEOSTASIS THERAPEUTICS IN COM 74373B109 63 50,000 SH   DFND 1 50,000 0 0
THE PROCTER&GAMBLE COMPANY COM 742718109 13,438 129,150 SH   DFND 1 129,150 0 0
ROCHE HOLDING AG SPONSORED ADR 771195104 5,733 166,700 SH   DFND 1 166,700 0 0
ROPER TECHNOLOGIES INC COM 776696106 24,143 70,600 SH   DFND 1 70,600 0 0
ROYAL DUTCH SHELL PLC CLASS B CL B 780259107 5,030 78,660 SH   DFND 1 78,660 0 0
SANOFI-AVENTIS SA SPONSORED ADR 80105N105 3,152 71,190 SH   DFND 1 71,190 0 0
SESEN BIO INC COM 817763105 218 212,055 SH   DFND 1 212,055 0 0
SIERRA ONCOLOGY INC COM 82640U107 428 250,000 SH   DFND 1 250,000 0 0
SINCLAIR BROADCAST GROUP, INC COM 829226109 334 8,670 SH   DFND 1 8,670 0 0
SOPHIRIS BIO INC COM 83578Q209 199 200,900 SH   DFND 1 200,900 0 0
SPRING BANK PHARMACEUTICALS COM 849431101 562 53,536 SH   DFND 1 53,536 0 0
STEMLINE THERAPEUTICS INC COM 85858C107 194 15,136 SH   DFND 1 15,136 0 0
STERICYCLE INC COM 858912108 3,233 59,400 SH   DFND 1 59,400 0 0
STORE CAPITAL CORPORATION REIT 862121100 1,229 36,700 SH   DFND 1 36,700 0 0
TARO PHARMACEUTICAL INDUSTRIES LTD COM M8737E108 277 2,560 SH   DFND 1 2,560 0 0
TEGNA INC COM 87901J105 335 23,790 SH   DFND 1 23,790 0 0
TG THERAPEUTICS INC COM 88322Q108 402 50,000 SH   DFND 1 50,000 0 0
UNITED TECHNOLOGIES CORP COM 913017109 13,701 106,300 SH   DFND 1 106,300 0 0
UNITED THERAPEUTICS CORPORATION COM 91307C102 270 2,300 SH   DFND 1 2,300 0 0
US BANCORP COM 902973304 5,624 116,700 SH   DFND 1 116,700 0 0
VANGUARD CONSUMER STAPLES ETF ETF 92204A207 5,896 40,600 SH   DFND 1 40,600 0 0
VANGUARD FTSE EMERGING MARKETS ETF ETF 922042858 4,035 94,930 SH   DFND 1 94,930 0 0
VANGUARD S&P 500 ETF ETF 922908363 10,101 38,920 SH   DFND 1 38,920 0 0
VANGUARD SMALL- CAP ETF ETF 922908751 1,588 10,390 SH   DFND 1 10,390 0 0
VIKING THERAPEUTICS IN COM 92686J106 497 50,000 SH   DFND 1 50,000 0 0
VISA INC CLASS A CL A 92826C839 23,944 153,300 SH   DFND 1 153,300 0 0
VISTAGEN THERAPEUTICS INC COM 92840H202 14 10,635 SH   DFND 1 10,635 0 0
WABTEC CORPORATION COM 929740108 14,506 196,770 SH   DFND 1 196,770 0 0
WARRIOR MET COAL INC COM 93627C101 350 11,500 SH   DFND 1 11,500 0 0
WATERS CORPORATION COM 941848103 13,177 52,350 SH   DFND 1 52,350 0 0
WELLS FARGO & CO COM 949746101 74,626 1,544,420 SH   DFND 1 1,544,420 0 0
YUM!BRANDS, INC COM 988498101 298 2,990 SH   DFND 1 2,990 0 0
ZAFGEN INC COM 98885E103 412 150,521 SH   DFND 1 150,521 0 0
ZTO EXPRESS CAYMAN INC SPONSORED ADR 98980A105 299 16,330 SH   DFND 1 16,330 0 0