The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
3M CO COM 88579Y101 34,408 180,580 SH   DFND 1 180,580 0 0
ACADIA PHARMACEUTICALS INC COM 004225108 323 20,000 SH   DFND 1 20,000 0 0
AKARI THERAPEUTICS PLC COM 00972G108 1,884 1,199,697 SH   DFND 1 1,199,697 0 0
ALDEYRA THERAPEUTICS INC COM 01438T106 500 60,190 SH   DFND 1 60,190 0 0
ALLERGAN PLC SPONSORED ADR G0177J108 22,776 170,400 SH   DFND 1 170,400 0 0
ALLISON TRANSMISSION HOLDINGS,INC COM 01973R101 273 6,220 SH   DFND 1 6,220 0 0
ALPHABET INC CLASS C CL C 38259P706 4,039 3,900 SH   DFND 1 0 0 3,900
ALPINE IMMUNE SCIENCES INC COM 02083G100 453 122,972 SH   DFND 1 122,972 0 0
ALTRIA GROUP INC COM 02209S103 2,393 48,450 SH   DFND 1 48,450 0 0
AMC NETWORKS INC COM 00164V103 279 5,080 SH   DFND 1 5,080 0 0
AMERICAN EXPRESS CO COM 025816109 1,678 17,600 SH   DFND 1 17,600 0 0
AMGEN INC COM 031162100 6,644 34,130 SH   DFND 1 34,130 0 0
ANAVEX LIFE SCIENCES CORP COM 032797300 231 148,080 SH   DFND 1 148,080 0 0
ANHEUSER-BUSCH INBEV NV SPONSORED ADR 03524A108 8,147 123,800 SH   DFND 1 123,800 0 0
ANTHEM INC COM 036752103 299 1,140 SH   DFND 1 1,140 0 0
AT&T INC COM 00206R102 2,774 97,200 SH   DFND 1 97,200 0 0
AUTOHOME INC SPONSORED ADR 05278C107 209 2,670 SH   DFND 1 2,670 0 0
AVEO PHARMACEUTICALS INC COM 053588109 128 80,000 SH   DFND 1 80,000 0 0
BANK OF NEW YORK MELLON CORP COM 064058100 14,129 300,160 SH   DFND 1 300,160 0 0
BECTON DICKINSON & CO COM 075887109 5,137 22,800 SH   DFND 1 22,800 0 0
BERKSHIRE HATHAWAY INC CLASS A CL A 084670108 225,216 736 SH   DFND 1 736 0 0
BERKSHIRE HATHAWAY INC CLASS B COM 084670702 398 1,950 SH   DFND 1 1,950 0 0
BHP BILLITON PLC COM 05545E209 9,770 233,230 SH   DFND 1 233,230 0 0
BIOGEN INC COM 09062X103 4,291 14,260 SH   DFND 1 14,260 0 0
BOEING CO COM 097023105 20,737 64,300 SH   DFND 1 64,300 0 0
BRIGHT SCHOLAR EDUCATION HOLDINGS LTD SPONSORED ADR 109199109 149 16,140 SH   DFND 1 16,140 0 0
BRISTOL-MYERS SQUIBB CO COM 110122108 3,227 62,080 SH   DFND 1 62,080 0 0
BRITISH AMERICAN TOBACCO PLC COM 110448107 616 19,350 SH   DFND 1 19,350 0 0
THE BUCKLE, INC COM 118440106 220 11,400 SH   DFND 1 11,400 0 0
CALITHERA BIOSCIENCES,INC COM 13089P101 201 50,000 SH   DFND 1 50,000 0 0
CANNAE HOLDINGS INC COM 13765N107 229 13,400 SH   DFND 1 13,400 0 0
CELGENE CORP COM 151020104 2,927 45,670 SH   DFND 1 45,670 0 0
CHECK POINT SOFTWARE TECHNOLOGIES LTD COM M22465104 258 2,510 SH   DFND 1 2,510 0 0
CHINA MOBILE LIMITED SPONSORED ADR 16941M109 2,318 48,300 SH   DFND 1 48,300 0 0
CIGNA CORPORATION COM 125509109 5,450 28,697 SH   DFND 1 28,697 0 0
CIRRUS LOGIC, INC COM 172755100 217 6,530 SH   DFND 1 6,530 0 0
CISCO SYSTEMS INC COM 17275R102 6,846 158,000 SH   DFND 1 158,000 0 0
COCA COLA CO COM 191216100 2,178 46,000 SH   DFND 1 46,000 0 0
COLGATE-PALMOLIVE COMPANY COM 194162103 8,457 142,090 SH   DFND 1 142,090 0 0
CONATUS PHARMACEUTICALS INC COM 20600T108 289 167,288 SH   DFND 1 167,288 0 0
CORVUS PHARMACEUTICALS INC COM 221015100 477 130,000 SH   DFND 1 130,000 0 0
DANAHER CORP COM 235851102 22,253 215,800 SH   DFND 1 215,800 0 0
DAVITA HEALTHCARE PARTNERS INC COM 23918K108 5,438 105,680 SH   DFND 1 105,680 0 0
DEUTSCHE X-TRACKERS HARVEST CSI 300 CHINA A-SHARES FUND ETF 233051879 4,046 184,500 SH   DFND 1 184,500 0 0
DIAMOND OFFSHORE DRILLING INC COM 25271C102 332 35,200 SH   DFND 1 35,200 0 0
DYNAVAX TECHNOLOGIES CORPORATION COM 268158201 966 105,573 SH   DFND 1 105,573 0 0
ECOLAB INC COM 278865100 309 2,100 SH   DFND 1 2,100 0 0
EQUIFAX INC COM 294429AN5 260 2,790 SH   DFND 1 2,790 0 0
EXXON MOBIL CORPORATION COM 30231G102 8,755 128,393 SH   DFND 1 128,393 0 0
F5 NETWORKS, INC COM 315616102 269 1,660 SH   DFND 1 1,660 0 0
FORTIVE CORP COM 34959J108 9,587 141,700 SH   DFND 1 141,700 0 0
GENERAL ELECTRIC COMPANY COM 369604103 14,770 1,951,080 SH   DFND 1 1,951,080 0 0
GENERAL MILLS,INC COM 370334104 11,113 285,400 SH   DFND 1 285,400 0 0
GILEAD SCIENCES INC COM 375558103 5,295 84,650 SH   DFND 1 84,650 0 0
GRAY TELEVISION, INC COM 389375106 323 21,890 SH   DFND 1 21,890 0 0
H&R BLOCK, INC COM 093671105 248 9,760 SH   DFND 1 9,760 0 0
HOLOGIC, INC COM 436440101 282 6,850 SH   DFND 1 6,850 0 0
HOSTESS BRANDS,INC COM 44109J106 195 17,810 SH   DFND 1 17,810 0 0
HOULIHAN LOKEY, INC COM 441593100 211 5,740 SH   DFND 1 5,740 0 0
INTERDIGITAL INC COM 45867G101 217 3,270 SH   DFND 1 3,270 0 0
INTERNATIONAL BUSINESS MACHINES CORP COM 459200101 16,404 144,310 SH   DFND 1 144,310 0 0
INTUITIVE SURGICAL INC COM 46120E602 8,932 18,650 SH   DFND 1 18,650 0 0
ISHARES CORE HIGH DIVIDEND ETF COM 46429B663 1,561 18,500 SH   DFND 1 18,500 0 0
ISHARES NASDAQ BIOTECHNOLOGY ETF 464287556 2,498 25,900 SH   DFND 1 25,900 0 0
JACK HENRY & ASSOCIATES INC COM 426281101 1,733 13,700 SH   DFND 1 13,700 0 0
JOHNSON & JOHNSON COM 478160104 35,569 275,620 SH   DFND 1 275,620 0 0
KBR, INC COM 48242W106 228 15,040 SH   DFND 1 15,040 0 0
KLA-TENCOR CORPORATION COM 482480100 212 2,370 SH   DFND 1 2,370 0 0
THE KRAFT HEINZ COMPANY COM 500754106 12,641 293,710 SH   DFND 1 293,710 0 0
LINDE PUBLIC LIMITED COMPANY COM G5494J103 23,565 151,020 SH   DFND 1 151,020 0 0
LOEWS CORPORATION COM 540424108 442 9,700 SH   DFND 1 9,700 0 0
MASTERCARD INC CL A 57636Q104 1,887 10,000 SH   DFND 1 10,000 0 0
MC DERMOTT INTERNATIONAL,INC COM 580037703 494 75,600 SH   DFND 1 75,600 0 0
MCDONADLD'S CORP COM 580135101 1,786 10,060 SH   DFND 1 10,060 0 0
MEDTRONIC INC COM 585055106 4,612 50,700 SH   DFND 1 50,700 0 0
MERSANA THERAPEUTICS INC COM 59045L106 348 85,396 SH   DFND 1 85,396 0 0
THE MICHAELS COS INC COM 59408Q106 191 14,120 SH   DFND 1 14,120 0 0
MOODYS CORPORATION COM 20775CZK3 7,205 51,450 SH   DFND 1 51,450 0 0
MSG NETWORKS INC COM 553573106 272 11,540 SH   DFND 1 11,540 0 0
NATIONAL OILWELL VARCO INC COM 637071101 1,987 77,300 SH   DFND 1 77,300 0 0
NESTLE SA SPONSORED ADR 641069406 17,932 221,490 SH   DFND 1 221,490 0 0
NOVO NORDISK A/S SPONSORED ADR 670100205 15,620 339,040 SH   DFND 1 339,040 0 0
NOW INC COM 67011P100 648 55,675 SH   DFND 1 55,675 0 0
NUTRIEN LTD COM 67077M108 17,689 376,360 SH   DFND 1 376,360 0 0
OMNICOM GROUP INC COM 681919106 403 5,500 SH   DFND 1 5,500 0 0
ONESMART INTERNATIONAL EDUCATION GROUP LIMITED SPONSORED ADR 68276W103 187 23,940 SH   DFND 1 23,940 0 0
ORACLE CORPORATION COM 68389X105 253 5,600 SH   DFND 1 5,600 0 0
PACCAR INC COM 693718108 212 3,710 SH   DFND 1 3,710 0 0
PHILLIPS 66 COM 718546104 13,058 151,570 SH   DFND 1 151,570 0 0
PREMIER, INC COM 74051N102 306 8,200 SH   DFND 1 8,200 0 0
PROGENICS PHARMACEUTICALS INC COM 743187106 52 12,302 SH   DFND 1 12,302 0 0
THE PROCTER&GAMBLE COMPANY COM 742718109 16,012 174,200 SH   DFND 1 174,200 0 0
ROCHE HOLDING AG SPONSORED ADR 771195104 5,181 166,700 SH   DFND 1 166,700 0 0
ROPER TECHNOLOGIES INC COM 776696106 18,816 70,600 SH   DFND 1 70,600 0 0
ROYAL DUTCH SHELL PLC CLASS B CL B 780259107 4,112 68,600 SH   DFND 1 68,600 0 0
SANOFI-AVENTIS SA SPONSORED ADR 80105N105 5,949 137,040 SH   DFND 1 137,040 0 0
SENSATA TECHNOLOGIES HOLDING COM G8060N102 807 18,000 SH   DFND 1 18,000 0 0
SESEN BIO INC COM 817763105 290 204,505 SH   DFND 1 204,505 0 0
SIERRA ONCOLOGY INC COM 82640U107 330 250,000 SH   DFND 1 250,000 0 0
SINCLAIR BROADCAST GROUP, INC COM 829226109 228 8,670 SH   DFND 1 8,670 0 0
SOPHIRIS BIO INC COM 83578Q209 167 200,900 SH   DFND 1 200,900 0 0
SPRING BANK PHARMACEUTICALS COM 849431101 556 53,536 SH   DFND 1 53,536 0 0
STEMLINE THERAPEUTICS INC COM 85858C107 144 15,136 SH   DFND 1 15,136 0 0
STERICYCLE INC COM 858912108 2,179 59,400 SH   DFND 1 59,400 0 0
STORE CAPITAL CORPORATION REIT 862121100 1,039 36,700 SH   DFND 1 36,700 0 0
TARO PHARMACEUTICAL INDUSTRIES LTD COM M8737E108 217 2,560 SH   DFND 1 2,560 0 0
TEGNA INC COM 87901J105 259 23,790 SH   DFND 1 23,790 0 0
TG THERAPEUTICS INC COM 88322Q108 205 50,000 SH   DFND 1 50,000 0 0
UNITED TECHNOLOGIES CORP COM 913017109 17,394 163,350 SH   DFND 1 163,350 0 0
UNITED THERAPEUTICS CORPORATION COM 91307C102 250 2,300 SH   DFND 1 2,300 0 0
US BANCORP COM 902973304 5,333 116,700 SH   DFND 1 116,700 0 0
VANGUARD CONSUMER STAPLES ETF ETF 92204A207 5,326 40,600 SH   DFND 1 40,600 0 0
VANGUARD FTSE EMERGING MARKETS ETF COM 922042858 1,989 52,200 SH   DFND 1 52,200 0 0
VANGUARD S&P 500 ETF COM 922908363 7,490 32,590 SH   DFND 1 32,590 0 0
VIKING THERAPEUTICS IN COM 92686J106 306 40,000 SH   DFND 1 40,000 0 0
VISA INC CLASS A CL A 92826C839 22,680 171,900 SH   DFND 1 171,900 0 0
WABTEC CORPORATION COM 929740108 13,823 196,770 SH   DFND 1 196,770 0 0
WARRIOR MET COAL INC COM 93627C101 277 11,500 SH   DFND 1 11,500 0 0
WATERS CORPORATION COM 941848103 9,876 52,350 SH   DFND 1 52,350 0 0
WELLS FARGO & CO COM 949746101 71,167 1,544,420 SH   DFND 1 1,544,420 0 0
YUM!BRANDS, INC COM 988498101 275 2,990 SH   DFND 1 2,990 0 0
ZAFGEN INC COM 98885E103 641 129,521 SH   DFND 1 129,521 0 0
ZTO EXPRESS CAYMAN INC SPONSORED ADR 98980A105 259 16,330 SH   DFND 1 16,330 0 0