The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
3M CO COM 88579Y101 31,535 149,660 SH   DFND 1 149,660 0 0
58.COM, INC SPONSORED ADR 31680Q104 238 3,240 SH   DFND 1 3,240 0 0
ABEONA THERAPEUTICS INC COM 00289Y107 360 28,101 SH   DFND 1 28,101 0 0
ADAMAS PHARMACEUTICALS INC COM 00548A106 601 30,000 SH   DFND 1 30,000 0 0
AKARI THERAPEUTICS PLC COM 00972G108 2,560 1,000,000 SH   DFND 1 1,000,000 0 0
ALDEYRA THERAPEUTICS INC COM 01438T106 1,488 107,858 SH   DFND 1 107,858 0 0
ALLERGAN PLC SPONSORED ADR G0177J108 29,254 153,580 SH   DFND 1 153,580 0 0
ALLIANCE DATA SYSTEMS CORPORATION COM 018581108 288 1,220 SH   DFND 1 1,220 0 0
ALLISON TRANSMISSION HOLDINGS,INC COM 01973R101 324 6,220 SH   DFND 1 6,220 0 0
ALPHABET INC CLASS C CL C 38259P706 4,655 3,900 SH   DFND 1 0 0 3,900
ALTRIA GROUP INC COM 02209S103 2,922 48,450 SH   DFND 1 48,450 0 0
AMC NETWORKS INC COM 00164V103 337 5,080 SH   DFND 1 5,080 0 0
AMERICAN EXPRESS CO COM 025816109 1,874 17,600 SH   DFND 1 17,600 0 0
AMGEN INC COM 031162100 7,075 34,130 SH   DFND 1 34,130 0 0
ANHEUSER-BUSCH INBEV NV SPONSORED ADR 03524A108 8,490 96,950 SH   DFND 1 96,950 0 0
ANTHEM INC COM 036752103 312 1,140 SH   DFND 1 1,140 0 0
AUTOHOME INC SPONSORED ADR 05278C107 207 2,670 SH   DFND 1 2,670 0 0
BAIDU INC COM 056752108 261 1,140 SH   DFND 1 1,140 0 0
BANK OF NEW YORK MELLON CORP COM 064058100 1,290 25,300 SH   DFND 1 25,300 0 0
BECTON DICKINSON & CO COM 075887109 5,951 22,800 SH   DFND 1 22,800 0 0
BERKSHIRE HATHAWAY INC CLASS A CL A 084670108 232,000 725 SH   DFND 1 725 0 0
BERKSHIRE HATHAWAY INC CLASS B CL B 084670702 214 1,000 SH   DFND 1 1,000 0 0
BHP BILLITON PLC COM 05545E209 9,259 210,530 SH   DFND 1 210,530 0 0
BIODELIVERY SCIENCES INTERNATIONAL INC COM 09060J106 420 150,000 SH   DFND 1 150,000 0 0
BIOGEN INC COM 09062X103 5,038 14,260 SH   DFND 1 14,260 0 0
BOEING CO COM 097023105 23,913 64,300 SH   DFND 1 64,300 0 0
BRIGHT SCHOLAR EDUCATION HOLDINGS LTD SPONSORED ADR 109199109 200 16,140 SH   DFND 1 16,140 0 0
BRISTOL-MYERS SQUIBB CO COM 110122108 3,854 62,080 SH   DFND 1 62,080 0 0
BRITISH AMERICAN TOBACCO PLC COM 110448107 902 19,350 SH   DFND 1 19,350 0 0
THE BUCKLE, INC COM 118440106 263 11,400 SH   DFND 1 11,400 0 0
CA INC COM 12673P105 331 7,490 SH   DFND 1 7,490 0 0
CALITHERA BIOSCIENCES,INC COM 13089P101 525 100,000 SH   DFND 1 100,000 0 0
CANNAE HOLDINGS INC COM 13765N107 281 13,400 SH   DFND 1 13,400 0 0
CATALYST BIOSCIENCES INC COM 14888D208 323 30,000 SH   DFND 1 30,000 0 0
CELGENE CORP COM 151020104 4,132 46,170 SH   DFND 1 46,170 0 0
CHECK POINT SOFTWARE TECHNOLOGIES LTD COM M22465104 295 2,510 SH   DFND 1 2,510 0 0
CHINA MOBILE LIMITED SPONSORED ADR 16941M109 1,458 29,800 SH   DFND 1 29,800 0 0
CIGNA CORPORATION COM 125509109 312 1,500 SH   DFND 1 1,500 0 0
CIRRUS LOGIC, INC COM 172755100 252 6,530 SH   DFND 1 6,530 0 0
CISCO SYSTEMS INC COM 17275R102 7,687 158,000 SH   DFND 1 158,000 0 0
COCA COLA CO COM 191216100 2,125 46,000 SH   DFND 1 46,000 0 0
COLGATE-PALMOLIVE COMPANY COM 194162103 9,011 134,590 SH   DFND 1 134,590 0 0
CORVUS PHARMACEUTICALS INC COM 221015100 275 32,090 SH   DFND 1 32,090 0 0
CTRIP.COM INTERNATIONAL, LTD SPONSORED ADR 22943F100 225 6,050 SH   DFND 1 6,050 0 0
DANAHER CORP COM 235851102 23,449 215,800 SH   DFND 1 215,800 0 0
DAVITA HEALTHCARE PARTNERS INC COM 23918K108 19,336 269,940 SH   DFND 1 269,940 0 0
DEUTSCHE X-TRACKERS HARVEST CSI 300 CHINA A-SHARES FUND ETF 233051879 2,446 96,500 SH   DFND 1 96,500 0 0
DIAMOND OFFSHORE DRILLING INC COM 25271C102 704 35,200 SH   DFND 1 35,200 0 0
DYNAVAX TECHNOLOGIES CORPORATION COM 268158201 1,931 155,755 SH   DFND 1 155,755 0 0
ECOLAB INC COM 278865100 329 2,100 SH   DFND 1 2,100 0 0
EXPRESS SCRIPTS HOLDING INC COM 30219G108 10,616 111,740 SH   DFND 1 111,740 0 0
EXXON MOBIL CORPORATION COM 30231G102 11,086 130,393 SH   DFND 1 130,393 0 0
F5 NETWORKS, INC COM 315616102 331 1,660 SH   DFND 1 1,660 0 0
FORTIVE CORP COM 34959J108 11,931 141,700 SH   DFND 1 141,700 0 0
GENERAL ELECTRIC COMPANY COM 369604103 5,889 521,600 SH   DFND 1 521,600 0 0
GENERAL MILLS,INC COM 370334104 11,614 270,600 SH   DFND 1 270,600 0 0
GILEAD SCIENCES INC COM 375558103 6,536 84,650 SH   DFND 1 84,650 0 0
GRAY TELEVISION, INC COM 389375106 383 21,890 SH   DFND 1 21,890 0 0
H&R BLOCK, INC COM 093671105 251 9,760 SH   DFND 1 9,760 0 0
HOLOGIC, INC COM 436440101 281 6,850 SH   DFND 1 6,850 0 0
HOSTESS BRANDS,INC COM 44109J106 197 17,810 SH   DFND 1 17,810 0 0
HOULIHAN LOKEY, INC COM 441593100 258 5,740 SH   DFND 1 5,740 0 0
INTERDIGITAL INC COM 45867G101 262 3,270 SH   DFND 1 3,270 0 0
INTERNATIONAL BUSINESS MACHINES CORP COM 459200101 21,924 144,990 SH   DFND 1 144,990 0 0
INTUITIVE SURGICAL INC COM 46120E602 10,705 18,650 SH   DFND 1 18,650 0 0
ISHARES CORE HIGH DIVIDEND ETF COM 46429B663 1,675 18,500 SH   DFND 1 18,500 0 0
ISHARES NASDAQ BIOTECHNOLOGY ETF 464287556 3,158 25,900 SH   DFND 1 25,900 0 0
JACK HENRY & ASSOCIATES INC COM 426281101 2,193 13,700 SH   DFND 1 13,700 0 0
JOHNSON & JOHNSON COM 478160104 37,515 271,510 SH   DFND 1 271,510 0 0
KBR, INC COM 48242W106 318 15,040 SH   DFND 1 15,040 0 0
KLA-TENCOR CORPORATION COM 482480100 241 2,370 SH   DFND 1 2,370 0 0
THE KRAFT HEINZ COMPANY COM 500754106 14,005 254,130 SH   DFND 1 254,130 0 0
LOEWS CORPORATION COM 540424108 487 9,700 SH   DFND 1 9,700 0 0
MASTERCARD INC CL A 57636Q104 2,226 10,000 SH   DFND 1 10,000 0 0
MC DERMOTT INTERNATIONAL,INC COM 580037703 1,412 76,638 SH   DFND 1 76,638 0 0
MCDONADLD'S CORP COM 580135101 1,683 10,060 SH   DFND 1 10,060 0 0
MCKESSON CORPORATION COM 58155Q103 231 1,740 SH   DFND 1 1,740 0 0
MEDTRONIC INC COM 585055106 4,987 50,700 SH   DFND 1 50,700 0 0
THE MICHAELS COS INC COM 59408Q106 229 14,120 SH   DFND 1 14,120 0 0
MSG NETWORKS INC COM 553573106 298 11,540 SH   DFND 1 11,540 0 0
NATIONAL OILWELL VARCO INC COM 637071101 9,697 225,100 SH   DFND 1 225,100 0 0
NESTLE SA SPONSORED ADR 641069406 18,428 221,490 SH   DFND 1 221,490 0 0
NOVO NORDISK A/S SPONSORED ADR 670100205 15,982 339,040 SH   DFND 1 339,040 0 0
NOW INC COM 67011P100 921 55,675 SH   DFND 1 55,675 0 0
NUTRIEN LTD COM 67077M108 21,716 376,360 SH   DFND 1 376,360 0 0
OCULAR THERAPEUTIX INC COM 67576A100 826 120,001 SH   DFND 1 120,001 0 0
OMNICOM GROUP INC COM 681919106 374 5,500 SH   DFND 1 5,500 0 0
ONESMART INTERNATIONAL EDUCATION GROUP LIMITED SPONSORED ADR 68276W103 214 23,940 SH   DFND 1 23,940 0 0
ORACLE CORPORATION COM 68389X105 289 5,600 SH   DFND 1 5,600 0 0
PACCAR INC COM 693718108 253 3,710 SH   DFND 1 3,710 0 0
PHILLIPS 66 COM 718546104 27,669 245,470 SH   DFND 1 245,470 0 0
PRAXAIR INC COM 74005P104 24,273 151,020 SH   DFND 1 151,020 0 0
PREMIER, INC COM 74051N102 375 8,200 SH   DFND 1 8,200 0 0
THE PROCTER&GAMBLE COMPANY COM 742718109 14,499 174,200 SH   DFND 1 174,200 0 0
PROGENICS PHARMACEUTICALS INC COM 743187106 627 100,000 SH   DFND 1 100,000 0 0
RMR GROUP INC COM 74967R106 307 3,310 SH   DFND 1 3,310 0 0
ROCHE HOLDING AG SPONSORED ADR 771195104 5,028 166,700 SH   DFND 1 166,700 0 0
ROPER TECHNOLOGIES INC COM 776696106 21,037 71,020 SH   DFND 1 71,020 0 0
ROYAL DUTCH SHELL PLC CLASS B CL B 780259107 4,752 67,000 SH   DFND 1 67,000 0 0
SANOFI-AVENTIS SA SPONSORED ADR 80105N105 6,122 137,040 SH   DFND 1 137,040 0 0
SAREPTA THERAPEUTICS INC COM 803607100 1,615 10,000 SH   DFND 1 10,000 0 0
SENSATA TECHNOLOGIES HOLDING COM G8060N102 892 18,000 SH   DFND 1 18,000 0 0
SESEN BIO INC COM 817763105 141 65,592 SH   DFND 1 65,592 0 0
SINCLAIR BROADCAST GROUP, INC COM 829226109 246 8,670 SH   DFND 1 8,670 0 0
SOPHIRIS BIO INC COM 83578Q209 474 170,000 SH   DFND 1 170,000 0 0
SPRING BANK PHARMACEUTICALS COM 849431101 137 11,336 SH   DFND 1 11,336 0 0
STERICYCLE INC COM 858912108 2,793 47,600 SH   DFND 1 47,600 0 0
STORE CAPITAL CORPORATION REIT 862121100 1,020 36,700 SH   DFND 1 36,700 0 0
SYNERGY PHARMACEUTICALS INC COM 871639308 4,250 2,500,000 SH   DFND 1 2,500,000 0 0
SYNTEL INC COM 87162H103 1,281 31,270 SH   DFND 1 31,270 0 0
TARO PHARMACEUTICAL INDUSTRIES LTD COM M8737E108 252 2,560 SH   DFND 1 2,560 0 0
TEGNA INC COM 87901J105 285 23,790 SH   DFND 1 23,790 0 0
TG THERAPEUTICS INC COM 88322Q108 896 160,000 SH   DFND 1 160,000 0 0
UNITED TECHNOLOGIES CORP COM 913017109 22,838 163,350 SH   DFND 1 163,350 0 0
UNITED THERAPEUTICS CORPORATION COM 91307C102 294 2,300 SH   DFND 1 2,300 0 0
US BANCORP COM 902973304 6,057 114,700 SH   DFND 1 114,700 0 0
VANGUARD CONSUMER STAPLES ETF ETF 92204A207 5,689 40,600 SH   DFND 1 40,600 0 0
VANGUARD FTSE EMERGING MARKETS ETF COM 922042858 1,402 34,200 SH   DFND 1 34,200 0 0
VANGUARD S&P 500 ETF COM 922908363 6,861 25,690 SH   DFND 1 25,690 0 0
VISA INC CLASS A CL A 92826C839 25,800 171,900 SH   DFND 1 171,900 0 0
WABTEC CORPORATION COM 929740108 20,218 192,770 SH   DFND 1 192,770 0 0
WALKER & DUNLOP INC COM 93148P102 232 4,390 SH   DFND 1 4,390 0 0
WARRIOR MET COAL INC COM 93627C101 311 11,500 SH   DFND 1 11,500 0 0
WATERS CORPORATION COM 941848103 10,084 51,800 SH   DFND 1 51,800 0 0
WELLS FARGO & CO COM 949746101 81,175 1,544,420 SH   DFND 1 1,544,420 0 0
YUM!BRANDS, INC COM 988498101 272 2,990 SH   DFND 1 2,990 0 0
ZTO EXPRESS CAYMAN INC SPONSORED ADR 98980A105 271 16,330 SH   DFND 1 16,330 0 0