The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
3M CO COM 88579Y101 26,969 114,580 SH   DFND 1 114,580 0 0
ACADIA PHARMACEUTICALS INC COM 004225108 1,204 40,000 SH   DFND 1 40,000 0 0
ACHAOGEN INC COM 004449104 644 60,000 SH   DFND 1 60,000 0 0
ADAMAS PHARMACEUTICALS INC COM 00548A106 1,017 30,000 SH   DFND 1 30,000 0 0
AKARI THERAPEUTICS PLC COM 00972G108 655 151,334 SH   DFND 1 151,334 0 0
ALDEYRA THERAPEUTICS INC COM 01438T106 733 107,858 SH   DFND 1 107,858 0 0
ALLERGAN PLC SPONSORED ADR G0177J108 14,804 90,500 SH   DFND 1 90,500 0 0
ALPHABET INC CL C 38259P706 4,081 3,900 SH   DFND 1 0 0 3,900
AMAG PHARMACEUTICALS INC COM 00163U106 1,060 80,000 SH   DFND 1 80,000 0 0
AMERICAN EXPRESS CO COM 025816109 1,748 17,600 SH   DFND 1 17,600 0 0
AMGEN INC COM 031162100 10,081 57,970 SH   DFND 1 57,970 0 0
ANHEUSER-BUSCH INBEV NV SPONSORED ADR 03524A108 1,127 10,100 SH   DFND 1 10,100 0 0
APPLE INC COM 037833100 228 1,350 SH   DFND 1 1,350 0 0
AXOVANT SCIENCES LTD COM G0750W104 377 71,607 SH   DFND 1 71,607 0 0
BAIDU INC COM 056752108 262 1,120 SH   DFND 1 1,120 0 0
BECTON DICKINSON & CO COM 075887109 4,881 22,800 SH   DFND 1 22,800 0 0
BERKSHIRE HATHAWAY INC CL A 084670108 210,998 709 SH   DFND 1 709 0 0
BEST BUY CO INC COM 086516101 278 4,060 SH   DFND 1 4,060 0 0
BHP BILLITON PLC COM 05545E209 5,207 129,200 SH   DFND 1 129,200 0 0
BIODELIVERY SCIENCES INTERNATIONAL INC COM 09060J106 1,774 601,285 SH   DFND 1 601,285 0 0
BIOGEN INC COM 09062X103 7,238 22,720 SH   DFND 1 22,720 0 0
BIOVERATIV INC COM 09075E100 593 11,000 SH   DFND 1 11,000 0 0
BOEING CO COM 097023105 18,963 64,300 SH   DFND 1 64,300 0 0
BRISTOL-MYERS SQUIBB CO COM 110122108 4,755 77,600 SH   DFND 1 77,600 0 0
CA INC COM 12673P105 204 6,130 SH   DFND 1 6,130 0 0
CELGENE CORP COM 151020104 7,511 71,970 SH   DFND 1 71,970 0 0
CHANGYOUCOM LTD COM 15911M107 267 7,340 SH   DFND 1 7,340 0 0
CHICAGO BRIDGE & IRON COMPANY N Y REGISTRY SH 167250109 1,501 93,000 SH   DFND 1 93,000 0 0
CIGNA CORPORATION COM 125509109 262 1,290 SH   DFND 1 1,290 0 0
CISCO SYSTEMS INC COM 17275R102 6,277 163,890 SH   DFND 1 163,890 0 0
COCA COLA CO COM 191216100 2,110 46,000 SH   DFND 1 46,000 0 0
CSG SYSTEMS INTERNATIONAL INC COM 126349109 234 5,350 SH   DFND 1 5,350 0 0
DANAHER CORP COM 235851102 20,031 215,800 SH   DFND 1 215,800 0 0
DAVITA HEALTHCARE PARTNERS INC COM 23918K108 24,126 333,920 SH   DFND 1 333,920 0 0
DEUTSCHE X-TRACKERS HARVEST CSI 300 CHINA A-SHARES FUND ETF 233051879 1,610 51,900 SH   DFND 1 51,900 0 0
DIAMOND OFFSHORE DRILLING INC COM 25271C102 2,116 113,800 SH   DFND 1 113,800 0 0
DYNAVAX TECHNOLOGIES CORPORATION COM 268158201 2,034 108,755 SH   DFND 1 108,755 0 0
ECOLAB INC COM 278865100 282 2,100 SH   DFND 1 2,100 0 0
EXPRESS SCRIPTS HOLDING INC COM 30219G108 10,047 134,600 SH   DFND 1 134,600 0 0
EXXON MOBIL CORPORATION COM 30231G102 6,816 81,493 SH   DFND 1 81,493 0 0
FORTIVE CORP COM 34959J108 10,252 141,700 SH   DFND 1 141,700 0 0
GENERAL ELECTRIC COMPANY COM 369604103 1,312 75,200 SH   DFND 1 75,200 0 0
GENTEX CORPORATION COM 371901109 203 9,680 SH   DFND 1 9,680 0 0
GILEAD SCIENCES INC COM 375558103 10,598 147,930 SH   DFND 1 147,930 0 0
INTERNATIONAL BUSINESS MACHINES CORP COM 459200101 46,716 304,500 SH   DFND 1 304,500 0 0
INTUITIVE SURGICAL INC COM 46120E602 8,507 23,310 SH   DFND 1 23,310 0 0
JACK HENRY & ASSOCIATES INC COM 426281101 1,602 13,700 SH   DFND 1 13,700 0 0
JOHNSON & JOHNSON COM 478160104 24,855 177,890 SH   DFND 1 177,890 0 0
THE KRAFT HEINZ COMPANY COM 500754106 2,023 26,020 SH   DFND 1 26,020 0 0
L BRANDS INC COM 501797104 245 4,070 SH   DFND 1 4,070 0 0
LOEWS CORPORATION COM 540424108 485 9,700 SH   DFND 1 9,700 0 0
MASTERCARD INC CL A 57636Q104 1,514 10,000 SH   DFND 1 10,000 0 0
MCDONADLD'S CORP COM 580135101 1,732 10,060 SH   DFND 1 10,060 0 0
MEDTRONIC INC COM 585055106 4,094 50,700 SH   DFND 1 50,700 0 0
THE MICHAELS COS INC COM 59408Q106 204 8,450 SH   DFND 1 8,450 0 0
MICHAEL KORS HOLDINGS LTD COM G60754101 331 5,260 SH   DFND 1 5,260 0 0
NATIONAL OILWELL VARCO INC COM 637071101 12,023 333,800 SH   DFND 1 333,800 0 0
NESTLE SA SPONSORED ADR 641069406 4,203 48,890 SH   DFND 1 48,890 0 0
NETEASE INC COM 64110W102 242 700 SH   DFND 1 700 0 0
NOVO NORDISK A/S SPONSORED ADR 670100205 22,745 423,800 SH   DFND 1 423,800 0 0
NOW INC COM 67011P100 614 55,675 SH   DFND 1 55,675 0 0
NVR INC COM 62944T105 316 90 SH   DFND 1 90 0 0
OCULAR THERAPEUTIX INC COM 67576A100 356 80,011 SH   DFND 1 80,011 0 0
OMNICOM GROUP INC COM 681919106 306 4,200 SH   DFND 1 4,200 0 0
PHILLIPS 66 COM 718546104 23,527 232,600 SH   DFND 1 232,600 0 0
POTASH CORP SASK INC COM 73755L107 19,430 940,900 SH   DFND 1 940,900 0 0
PRAXAIR INC COM 74005P104 23,471 151,740 SH   DFND 1 151,740 0 0
PROGENICS PHARMACEUTICALS INC COM 743187106 1,190 200,000 SH   DFND 1 200,000 0 0
QUALCOMM INC COM 747525103 221 3,450 SH   DFND 1 3,450 0 0
RAYTHEON COMPANY COM 755111507 242 1,290 SH   DFND 1 1,290 0 0
ROBERT HALF INTERNATIONAL INC COM 770323103 237 4,260 SH   DFND 1 4,260 0 0
ROCHE HOLDING AG SPONSORED ADR 771195104 4,945 156,600 SH   DFND 1 156,600 0 0
ROPER TECHNOLOGIES INC COM 776696106 18,394 71,020 SH   DFND 1 71,020 0 0
SANOFI-AVENTIS SA SPONSORED ADR 80105N105 7,366 171,300 SH   DFND 1 171,300 0 0
SAREPTATHERAPEUTICS INC COM 803607100 1,391 25,000 SH   DFND 1 25,000 0 0
SCRIPPS NETWORKS INTERACTIVE INC COM 811065101 214 2,510 SH   DFND 1 2,510 0 0
SILICON MOTION TECHNOLOGY CORPORATION COM 82706C108 224 4,230 SH   DFND 1 4,230 0 0
STERICYCLE INC COM 858912108 2,890 42,500 SH   DFND 1 42,500 0 0
STEVEN MADDEN LTD COM 556269108 247 5,290 SH   DFND 1 5,290 0 0
STORE CAPITAL CORPORATION REIT 862121100 956 36,700 SH   DFND 1 36,700 0 0
SYNCHRONY FINANCIAL COM 87165B103 243 6,300 SH   DFND 1 6,300 0 0
SYNERGY PHARMACEUTICALS INC COM 871639308 4,237 1,900,000 SH   DFND 1 1,900,000 0 0
SYNTEL INC COM 87162H103 719 31,270 SH   DFND 1 31,270 0 0
TEMPUR SEALY INTERNATIONAL INC COM 88023U101 273 4,350 SH   DFND 1 4,350 0 0
TG THERAPEUTICS INC COM 88322Q108 1,312 160,000 SH   DFND 1 160,000 0 0
TUNIU CORPORATION COM 89977P106 180 23,520 SH   DFND 1 23,520 0 0
UBIQUITI NETWORKS INC COM 90347A100 281 3,950 SH   DFND 1 3,950 0 0
UNITED RENTALS INC COM 911363109 270 1,570 SH   DFND 1 1,570 0 0
UNITED TECHNOLOGIES CORP COM 913017109 21,132 165,650 SH   DFND 1 165,650 0 0
UNITED THERAPEUTICS CORPORATION COM 91307C102 1,700 11,490 SH   DFND 1 11,490 0 0
USANA HEALTH SCIENCES INC COM 90328M107 255 3,440 SH   DFND 1 3,440 0 0
US BANCORP COM 902973304 6,049 112,900 SH   DFND 1 112,900 0 0
VANGUARD FTSE EMERGING MARKETS ETF COM 922042858 505 11,000 SH   DFND 1 11,000 0 0
VANGUARD S&P 500 ETF COM 922908363 4,513 18,400 SH   DFND 1 18,400 0 0
VERISIGN INC COM 92343E102 255 2,230 SH   DFND 1 2,230 0 0
VIPSHOP HOLDINGS LTD COM 92763W103 169 14,450 SH   DFND 1 14,450 0 0
VISA INC CL A 92826C839 19,600 171,900 SH   DFND 1 171,900 0 0
WABASH NATIONAL CORPORATION COM 929566107 206 9,510 SH   DFND 1 9,510 0 0
WABTEC CORPORATION COM 929740108 15,697 192,770 SH   DFND 1 192,770 0 0
WATERS CORPORATION COM 941848103 10,007 51,800 SH   DFND 1 51,800 0 0
WELLS FARGO & CO COM 949746101 93,700 1,544,420 SH   DFND 1 1,544,420 0 0