X0306 4 2017-11-21 1 0001604950 scPharmaceuticals Inc. SCPH 0001171005 SILVERSTEIN JONATHAN C/O SCPHARMACEUTICALS INC 2400 DISTRICT AVENUE, SUITE 310 BURLINGTON MA 01830 1 0 0 0 Common Stock 2017-11-21 4 C 0 2576532 A 2576532 I By: OrbiMed Private Investments VI, L.P. Series B Preferred Stock 2017-11-21 4 C 0 18500000 0.00 D Common Stock 2576532 0 I By: OrbiMed Private Investments VI, L.P. Represents the total number of shares of Common Stock received by OrbiMed Private Investments VI, L.P. ("OPI VI"), upon conversion of the Issuer's Series B Preferred Stock in connection with the closing of the Issuer's initial public offering. The shares of Series B Preferred Stock are held of record by OPI VI. OrbiMed Capital GP VI LLC ("GP VI") is the sole general partner of OPI VI, and OrbiMed Advisors LLC ("Advisors"), a registered adviser under the Investment Advisers Act of 1940, as amended, is the sole managing member of GP VI. Jonathan Silverstein, a natural person, is a managing member of, and holder of a controlling interest in Advisors. The reporting person disclaims beneficial ownership of such shares except to the extent of his pecuniary interest, if any, and this report shall not be deemed an admission that the reporting person is the beneficial owner of all of the reported shares for purposes of Section 16 or any other purpose. All series of Convertible Preferred Stock automatically converted into the Issuer's Common Stock on a 7.180193-for-1 basis on November 21, 2017 and had no expiration date. /s/ Courtney Gaughan, Attorney-in-Fact 2017-11-21