<?xml version="1.0" encoding="UTF-8"?><own:edgarSubmission xmlns:com="http://www.sec.gov/edgar/common" xmlns:own="http://www.sec.gov/edgar/ownership">
  <!-- Generated by Workiva -->
  <own:headerData>
    <own:submissionType>144</own:submissionType>
    <own:filerInfo>
      <own:filer>
        <own:filerCredentials>
          <own:cik>0002010019</own:cik>
          <own:ccc>XXXXXXXX</own:ccc>
        </own:filerCredentials>
      </own:filer>
      <own:liveTestFlag>LIVE</own:liveTestFlag>



    </own:filerInfo>
  </own:headerData>
  <own:formData>
    <own:issuerInfo>
      <own:issuerCik>0001604821</own:issuerCik>
      <own:issuerName>NATERA, INC.</own:issuerName>
      <own:secFileNumber>001-37478</own:secFileNumber>
      <own:issuerAddress>
        <com:street1>13011 MCCALLEN PASS</com:street1>
        <com:street2>BLDG A, STE 100</com:street2>
        <com:city>AUSTIN</com:city>
        <com:stateOrCountry>TX</com:stateOrCountry>
        <com:zipCode>78753</com:zipCode>
      </own:issuerAddress>
      <own:issuerContactPhone>6509809190</own:issuerContactPhone>
      <own:nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>SOLOMON MOSHKEVICH</own:nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <own:relationshipsToIssuer>
        <own:relationshipToIssuer>OFFICER</own:relationshipToIssuer>
      </own:relationshipsToIssuer>
    </own:issuerInfo>
    <own:securitiesInformation>
      <own:securitiesClassTitle>Common Stock</own:securitiesClassTitle>
      <own:brokerOrMarketmakerDetails>
        <own:name>ETrade Corporation</own:name>
        <own:address>
          <com:street1>3 Edison Financial</com:street1>
          <com:city>Alphareta</com:city>
          <com:stateOrCountry>GA</com:stateOrCountry>
          <com:zipCode>30005</com:zipCode>
        </own:address>
      </own:brokerOrMarketmakerDetails>
      <own:noOfUnitsSold>998</own:noOfUnitsSold>
      <own:aggregateMarketValue>261466.02</own:aggregateMarketValue>
      <own:noOfUnitsOutstanding>143215382</own:noOfUnitsOutstanding>
      <own:approxSaleDate>07/27/2026</own:approxSaleDate>
      <own:securitiesExchangeName>NASDAQ</own:securitiesExchangeName>
    </own:securitiesInformation>
    <own:securitiesToBeSold>
      <own:securitiesClassTitle>Common Stock</own:securitiesClassTitle>
      <own:acquiredDate>01/26/2024</own:acquiredDate>
      <own:natureOfAcquisitionTransaction>Restricted Stock Units</own:natureOfAcquisitionTransaction>
      <own:nameOfPersonfromWhomAcquired>Issuer</own:nameOfPersonfromWhomAcquired>
      <own:isGiftTransaction>N</own:isGiftTransaction>
      <own:amountOfSecuritiesAcquired>31352</own:amountOfSecuritiesAcquired>
      <own:paymentDate>01/26/2024</own:paymentDate>
      <own:natureOfPayment>Services rendered</own:natureOfPayment>
    </own:securitiesToBeSold>
    <own:nothingToReportFlagOnSecuritiesSoldInPast3Months>N</own:nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <own:securitiesSoldInPast3Months>
      <own:sellerDetails>
        <own:name>SOLOMON MOSHKEVICH</own:name>
        <own:address>
          <com:street1>13011 MCCALLEN PASS</com:street1>
          <com:street2>BLDG A, STE 100</com:street2>
          <com:city>AUSTIN</com:city>
          <com:stateOrCountry>TX</com:stateOrCountry>
          <com:zipCode>78753</com:zipCode>
        </own:address>
      </own:sellerDetails>
      <own:securitiesClassTitle>COMMON STOCK</own:securitiesClassTitle>
      <own:saleDate>07/01/2026</own:saleDate>
      <own:amountOfSecuritiesSold>3000</own:amountOfSecuritiesSold>
      <own:grossProceeds>818710.5</own:grossProceeds>
    </own:securitiesSoldInPast3Months>
    <own:securitiesSoldInPast3Months>
      <own:sellerDetails>
        <own:name>SOLOMON MOSHKEVICH</own:name>
        <own:address>
          <com:street1>13011 MCCALLEN PASS</com:street1>
          <com:street2>BLDG A, STE 100</com:street2>
          <com:city>AUSTIN</com:city>
          <com:stateOrCountry>TX</com:stateOrCountry>
          <com:zipCode>78753</com:zipCode>
        </own:address>
      </own:sellerDetails>
      <own:securitiesClassTitle>COMMON STOCK</own:securitiesClassTitle>
      <own:saleDate>06/01/2026</own:saleDate>
      <own:amountOfSecuritiesSold>3000</own:amountOfSecuritiesSold>
      <own:grossProceeds>655294.78</own:grossProceeds>
    </own:securitiesSoldInPast3Months>
    <own:securitiesSoldInPast3Months>
      <own:sellerDetails>
        <own:name>SOLOMON MOSHKEVICH</own:name>
        <own:address>
          <com:street1>13011 MCCALLEN PASS</com:street1>
          <com:street2>BLDG A, STE 100</com:street2>
          <com:city>AUSTIN</com:city>
          <com:stateOrCountry>TX</com:stateOrCountry>
          <com:zipCode>78753</com:zipCode>
        </own:address>
      </own:sellerDetails>
      <own:securitiesClassTitle>COMMON STOCK</own:securitiesClassTitle>
      <own:saleDate>05/26/2026</own:saleDate>
      <own:amountOfSecuritiesSold>1652</own:amountOfSecuritiesSold>
      <own:grossProceeds>335091.27</own:grossProceeds>
    </own:securitiesSoldInPast3Months>
    <own:securitiesSoldInPast3Months>
      <own:sellerDetails>
        <own:name>SOLOMON MOSHKEVICH</own:name>
        <own:address>
          <com:street1>13011 MCCALLEN PASS</com:street1>
          <com:street2>BLDG A, STE 100</com:street2>
          <com:city>AUSTIN</com:city>
          <com:stateOrCountry>TX</com:stateOrCountry>
          <com:zipCode>78753</com:zipCode>
        </own:address>
      </own:sellerDetails>
      <own:securitiesClassTitle>COMMON STOCK</own:securitiesClassTitle>
      <own:saleDate>05/01/2026</own:saleDate>
      <own:amountOfSecuritiesSold>3000</own:amountOfSecuritiesSold>
      <own:grossProceeds>610065.14</own:grossProceeds>
    </own:securitiesSoldInPast3Months>
    <own:securitiesSoldInPast3Months>
      <own:sellerDetails>
        <own:name>SOLOMON MOSHKEVICH</own:name>
        <own:address>
          <com:street1>13011 MCCALLEN PASS</com:street1>
          <com:street2>BLDG A, STE 100</com:street2>
          <com:city>AUSTIN</com:city>
          <com:stateOrCountry>TX</com:stateOrCountry>
          <com:zipCode>78753</com:zipCode>
        </own:address>
      </own:sellerDetails>
      <own:securitiesClassTitle>COMMON STOCK</own:securitiesClassTitle>
      <own:saleDate>05/01/2026</own:saleDate>
      <own:amountOfSecuritiesSold>405</own:amountOfSecuritiesSold>
      <own:grossProceeds>83494.8</own:grossProceeds>
    </own:securitiesSoldInPast3Months>
    <own:securitiesSoldInPast3Months>
      <own:sellerDetails>
        <own:name>SOLOMON MOSHKEVICH</own:name>
        <own:address>
          <com:street1>13011 MCCALLEN PASS</com:street1>
          <com:street2>BLDG A, STE 100</com:street2>
          <com:city>AUSTIN</com:city>
          <com:stateOrCountry>TX</com:stateOrCountry>
          <com:zipCode>78753</com:zipCode>
        </own:address>
      </own:sellerDetails>
      <own:securitiesClassTitle>COMMON STOCK</own:securitiesClassTitle>
      <own:saleDate>04/27/2026</own:saleDate>
      <own:amountOfSecuritiesSold>2182</own:amountOfSecuritiesSold>
      <own:grossProceeds>445340.9</own:grossProceeds>
    </own:securitiesSoldInPast3Months>
    <own:remarks>The securities to be sold were acquired upon the vesting of restricted stock units during the period of 07/26/26 through 07/26/26.</own:remarks>
    <own:noticeSignature>
      <own:noticeDate>07/27/2026</own:noticeDate>
      <own:signature>SOLOMON MOSHKEVICH</own:signature>
    </own:noticeSignature>
  </own:formData>
</own:edgarSubmission>
