<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001646649</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0001604821</issuerCik>
      <issuerName>Natera, Inc.</issuerName>
      <secFileNumber>001-37478</secFileNumber>
      <issuerAddress>
        <com:street1>13011 MCCALLEN PASS</com:street1>
        <com:street2>BUILDING A SUITE 100</com:street2>
        <com:city>AUSTIN</com:city>
        <com:stateOrCountry>TX</com:stateOrCountry>
        <com:zipCode>78753</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>650-249-9090</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Sheena Jonathan</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Director</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Charles Schwab &amp; Co., Inc.</name>
        <address>
          <com:street1>3000 Schwab Way</com:street1>
          <com:city>Westlake</com:city>
          <com:stateOrCountry>TX</com:stateOrCountry>
          <com:zipCode>76262</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>6000</noOfUnitsSold>
      <aggregateMarketValue>1201500.00</aggregateMarketValue>
      <noOfUnitsOutstanding>141731250</noOfUnitsOutstanding>
      <approxSaleDate>03/20/2026</approxSaleDate>
      <securitiesExchangeName>NASDAQ</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>COMMON</securitiesClassTitle>
      <acquiredDate>04/30/2012</acquiredDate>
      <natureOfAcquisitionTransaction>FOUNDERS SHARES</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>ISSUER</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>6000</amountOfSecuritiesAcquired>
      <paymentDate>04/30/2012</paymentDate>
      <natureOfPayment>NA</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Jonathan Sheena</name>
        <address>
          <com:street1>C/O 13011 McCallen Pass,</com:street1>
          <com:street2>Building A Suit 100</com:street2>
          <com:city>Austin</com:city>
          <com:stateOrCountry>TX</com:stateOrCountry>
          <com:zipCode>78753</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>COMMON</securitiesClassTitle>
      <saleDate>01/20/2026</saleDate>
      <amountOfSecuritiesSold>2981</amountOfSecuritiesSold>
      <grossProceeds>699755.00</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>JONATHAN SHEENA</name>
        <address>
          <com:street1>C/O 13011 McCallen Pass</com:street1>
          <com:street2>Building A Suite 100</com:street2>
          <com:city>Austin</com:city>
          <com:stateOrCountry>TX</com:stateOrCountry>
          <com:zipCode>78753</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>COMMON</securitiesClassTitle>
      <saleDate>01/21/2026</saleDate>
      <amountOfSecuritiesSold>3163</amountOfSecuritiesSold>
      <grossProceeds>741611.00</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>JONATHAN SHEENA C/O</name>
        <address>
          <com:street1>13011 McCallen Pass</com:street1>
          <com:street2>Building A Suite 100</com:street2>
          <com:city>Austin</com:city>
          <com:stateOrCountry>TX</com:stateOrCountry>
          <com:zipCode>78753</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>COMMON</securitiesClassTitle>
      <saleDate>01/23/2026</saleDate>
      <amountOfSecuritiesSold>1500</amountOfSecuritiesSold>
      <grossProceeds>365914.00</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>JONATHAN SHEENA</name>
        <address>
          <com:street1>C/O 13011 McCallen Pass</com:street1>
          <com:street2>Building A Suite 100</com:street2>
          <com:city>Austin</com:city>
          <com:stateOrCountry>TX</com:stateOrCountry>
          <com:zipCode>78753</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>COMMON</securitiesClassTitle>
      <saleDate>01/27/2026</saleDate>
      <amountOfSecuritiesSold>291</amountOfSecuritiesSold>
      <grossProceeds>69994.00</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>JONATHAN SHEENA</name>
        <address>
          <com:street1>C/O 13011 McCallen Pass</com:street1>
          <com:street2>Building A Suite 100</com:street2>
          <com:city>Austin</com:city>
          <com:stateOrCountry>TX</com:stateOrCountry>
          <com:zipCode>78753</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>COMMON</securitiesClassTitle>
      <saleDate>01/28/2026</saleDate>
      <amountOfSecuritiesSold>191</amountOfSecuritiesSold>
      <grossProceeds>45393.00</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>JONATHAN SHEENA</name>
        <address>
          <com:street1>C/O 13011 McCallen Pass</com:street1>
          <com:street2>Building A Suite 100</com:street2>
          <com:city>Austin</com:city>
          <com:stateOrCountry>TX</com:stateOrCountry>
          <com:zipCode>78753</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>COMMON</securitiesClassTitle>
      <saleDate>02/03/2026</saleDate>
      <amountOfSecuritiesSold>435</amountOfSecuritiesSold>
      <grossProceeds>100384.00</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>JONATHAN SHEENA</name>
        <address>
          <com:street1>C/O 13011 McCallen Pass</com:street1>
          <com:street2>Building A Suite 100</com:street2>
          <com:city>Austin</com:city>
          <com:stateOrCountry>TX</com:stateOrCountry>
          <com:zipCode>78753</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>COMMON</securitiesClassTitle>
      <saleDate>03/02/2026</saleDate>
      <amountOfSecuritiesSold>3070</amountOfSecuritiesSold>
      <grossProceeds>614710.00</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>JONATHAN SHEENA</name>
        <address>
          <com:street1>C/O 13011 McCallen Pass</com:street1>
          <com:street2>Building A Suite 100</com:street2>
          <com:city>Austin</com:city>
          <com:stateOrCountry>TX</com:stateOrCountry>
          <com:zipCode>78753</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>COMMON</securitiesClassTitle>
      <saleDate>03/04/2026</saleDate>
      <amountOfSecuritiesSold>1500</amountOfSecuritiesSold>
      <grossProceeds>308601.00</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>JONATHAN SHEENA</name>
        <address>
          <com:street1>C/O 13011 McCallen Pass</com:street1>
          <com:street2>Building A Suite 100</com:street2>
          <com:city>Austin</com:city>
          <com:stateOrCountry>TX</com:stateOrCountry>
          <com:zipCode>78753</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>COMMON</securitiesClassTitle>
      <saleDate>03/10/2026</saleDate>
      <amountOfSecuritiesSold>127</amountOfSecuritiesSold>
      <grossProceeds>25924.00</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>JONATHAN SHEENA</name>
        <address>
          <com:street1>C/O 13011 McCallen Pass</com:street1>
          <com:street2>Building A Suite 100</com:street2>
          <com:city>Austin</com:city>
          <com:stateOrCountry>TX</com:stateOrCountry>
          <com:zipCode>78753</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>COMMON</securitiesClassTitle>
      <saleDate>03/18/2026</saleDate>
      <amountOfSecuritiesSold>3070</amountOfSecuritiesSold>
      <grossProceeds>608370.00</grossProceeds>
    </securitiesSoldInPast3Months>
    <remarks>FULL ACCOUNT TITLES: CARALUNA 1 TRUST CARALUNA 1 LLC, CARALUNA 2 TRUST CARALUNA 2 LLC</remarks>
    <noticeSignature>
      <noticeDate>03/20/2026</noticeDate>
      <planAdoptionDates>
        <planAdoptionDate>06/04/2025</planAdoptionDate>
      </planAdoptionDates>
      <signature>Jonathan Sheena</signature>
    </noticeSignature>
  </formData>
</edgarSubmission>
