<?xml version="1.0" encoding="UTF-8"?><own:edgarSubmission xmlns:com="http://www.sec.gov/edgar/common" xmlns:own="http://www.sec.gov/edgar/ownership">
  <!-- Generated by Workiva -->
  <own:headerData>
    <own:submissionType>144</own:submissionType>
    <own:filerInfo>
      <own:filer>
        <own:filerCredentials>
          <own:cik>0001711968</own:cik>
          <own:ccc>XXXXXXXX</own:ccc>
        </own:filerCredentials>
      </own:filer>
      <own:liveTestFlag>LIVE</own:liveTestFlag>



    </own:filerInfo>
  </own:headerData>
  <own:formData>
    <own:issuerInfo>
      <own:issuerCik>0001604821</own:issuerCik>
      <own:issuerName>NATERA, INC.</own:issuerName>
      <own:secFileNumber>001-37478</own:secFileNumber>
      <own:issuerAddress>
        <com:street1>13011 MCCALLEN PASS</com:street1>
        <com:street2>BLDG A, STE 100</com:street2>
        <com:city>AUSTIN</com:city>
        <com:stateOrCountry>TX</com:stateOrCountry>
        <com:zipCode>78753</com:zipCode>
      </own:issuerAddress>
      <own:issuerContactPhone>6509809190</own:issuerContactPhone>
      <own:nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>STEVEN CHAPMAN</own:nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <own:relationshipsToIssuer>
        <own:relationshipToIssuer>OFFICER</own:relationshipToIssuer>
        <own:relationshipToIssuer>DIRECTOR</own:relationshipToIssuer>
      </own:relationshipsToIssuer>
    </own:issuerInfo>
    <own:securitiesInformation>
      <own:securitiesClassTitle>Common Stock</own:securitiesClassTitle>
      <own:brokerOrMarketmakerDetails>
        <own:name>ETrade Corporation</own:name>
        <own:address>
          <com:street1>3 Edison Financial</com:street1>
          <com:city>Alphareta</com:city>
          <com:stateOrCountry>GA</com:stateOrCountry>
          <com:zipCode>30005</com:zipCode>
        </own:address>
      </own:brokerOrMarketmakerDetails>
      <own:noOfUnitsSold>3525</own:noOfUnitsSold>
      <own:aggregateMarketValue>909555.75</own:aggregateMarketValue>
      <own:noOfUnitsOutstanding>143215382</own:noOfUnitsOutstanding>
      <own:approxSaleDate>07/28/2026</own:approxSaleDate>
      <own:securitiesExchangeName>NASDAQ</own:securitiesExchangeName>
    </own:securitiesInformation>
    <own:securitiesToBeSold>
      <own:securitiesClassTitle>Common Stock</own:securitiesClassTitle>
      <own:acquiredDate>01/27/2023</own:acquiredDate>
      <own:natureOfAcquisitionTransaction>Restricted Stock Units</own:natureOfAcquisitionTransaction>
      <own:nameOfPersonfromWhomAcquired>Issuer</own:nameOfPersonfromWhomAcquired>
      <own:isGiftTransaction>N</own:isGiftTransaction>
      <own:amountOfSecuritiesAcquired>127265</own:amountOfSecuritiesAcquired>
      <own:paymentDate>01/27/2023</own:paymentDate>
      <own:natureOfPayment>Services rendered</own:natureOfPayment>
    </own:securitiesToBeSold>
    <own:nothingToReportFlagOnSecuritiesSoldInPast3Months>N</own:nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <own:securitiesSoldInPast3Months>
      <own:sellerDetails>
        <own:name>STEVEN CHAPMAN</own:name>
        <own:address>
          <com:street1>13011 MCCALLEN PASS</com:street1>
          <com:street2>BLDG A, STE 100</com:street2>
          <com:city>AUSTIN</com:city>
          <com:stateOrCountry>TX</com:stateOrCountry>
          <com:zipCode>78753</com:zipCode>
        </own:address>
      </own:sellerDetails>
      <own:securitiesClassTitle>COMMON STOCK</own:securitiesClassTitle>
      <own:saleDate>07/27/2026</own:saleDate>
      <own:amountOfSecuritiesSold>2190</own:amountOfSecuritiesSold>
      <own:grossProceeds>570474.8</own:grossProceeds>
    </own:securitiesSoldInPast3Months>
    <own:securitiesSoldInPast3Months>
      <own:sellerDetails>
        <own:name>STEVEN CHAPMAN</own:name>
        <own:address>
          <com:street1>13011 MCCALLEN PASS</com:street1>
          <com:street2>BLDG A, STE 100</com:street2>
          <com:city>AUSTIN</com:city>
          <com:stateOrCountry>TX</com:stateOrCountry>
          <com:zipCode>78753</com:zipCode>
        </own:address>
      </own:sellerDetails>
      <own:securitiesClassTitle>COMMON STOCK</own:securitiesClassTitle>
      <own:saleDate>06/04/2026</own:saleDate>
      <own:amountOfSecuritiesSold>41124</own:amountOfSecuritiesSold>
      <own:grossProceeds>9089777.54</own:grossProceeds>
    </own:securitiesSoldInPast3Months>
    <own:securitiesSoldInPast3Months>
      <own:sellerDetails>
        <own:name>STEVEN CHAPMAN</own:name>
        <own:address>
          <com:street1>13011 MCCALLEN PASS</com:street1>
          <com:street2>BLDG A, STE 100</com:street2>
          <com:city>AUSTIN</com:city>
          <com:stateOrCountry>TX</com:stateOrCountry>
          <com:zipCode>78753</com:zipCode>
        </own:address>
      </own:sellerDetails>
      <own:securitiesClassTitle>COMMON STOCK</own:securitiesClassTitle>
      <own:saleDate>05/01/2026</own:saleDate>
      <own:amountOfSecuritiesSold>902</own:amountOfSecuritiesSold>
      <own:grossProceeds>185956.32</own:grossProceeds>
    </own:securitiesSoldInPast3Months>
    <own:securitiesSoldInPast3Months>
      <own:sellerDetails>
        <own:name>STEVEN CHAPMAN</own:name>
        <own:address>
          <com:street1>13011 MCCALLEN PASS</com:street1>
          <com:street2>BLDG A, STE 100</com:street2>
          <com:city>AUSTIN</com:city>
          <com:stateOrCountry>TX</com:stateOrCountry>
          <com:zipCode>78753</com:zipCode>
        </own:address>
      </own:sellerDetails>
      <own:securitiesClassTitle>COMMON STOCK</own:securitiesClassTitle>
      <own:saleDate>04/27/2026</own:saleDate>
      <own:amountOfSecuritiesSold>5838</own:amountOfSecuritiesSold>
      <own:grossProceeds>1191774.74</own:grossProceeds>
    </own:securitiesSoldInPast3Months>
    <own:remarks>The securities to be sold were acquired upon the vesting of restricted stock units during the period of July 27, 2026 through July 27, 2026.</own:remarks>
    <own:noticeSignature>
      <own:noticeDate>07/28/2026</own:noticeDate>
      <own:signature>Steven Chapman</own:signature>
    </own:noticeSignature>
  </own:formData>
</own:edgarSubmission>
