Exhibit 5.1

August 7, 2026

Natera, Inc.

13011 McCallen Pass

Building A Suite 100

Austin, TX 78753

Ladies and Gentlemen:

We refer to the registration statement on Form S-8 (the “Registration Statement”) to be filed by Natera,

Inc., a Delaware corporation (the “Company”), with the Securities and Exchange Commission (the

“Commission”) in connection with the registration under the Securities Act of 1933, as amended (the

“Act”), of an aggregate of 3,200,000 shares of the Company’s common stock, $0.0001 par value per share

(the “Shares”), that are subject to issuance by the Company upon the exercise or settlement of awards

granted or to be granted under the Company’s Amended and Restated 2015 Equity Incentive Plan. The

Company’s Amended and Restated 2015 Equity Incentive Plan is referred to in this letter as the “Plan”.

In connection with this opinion, we have reviewed the actions proposed to be taken by you in connection

with the issuance and sale of the Shares to be issued under the Plan. We have also examined and relied

upon the Registration Statement and the originals or copies certified to our satisfaction of such other

documents, records, certificates, memoranda and other instruments as in our judgment are necessary or

appropriate to enable us to render the opinion expressed below. With your consent, we have relied upon

certificates and other assurances of officers of the Company as to factual matters without having

independently verified such factual matters. We have assumed the genuineness and authenticity of all

documents submitted to us as originals, and the conformity to originals of all documents submitted to us

as copies thereof and the due execution and delivery of all documents where due execution and delivery
are a prerequisite to the effectiveness thereof.

This opinion is being furnished in connection with the requirements of Item 601(b)(5) of Regulation S-K

under the Act, and no opinion is expressed herein as to any matter pertaining to the contents of the

Registration Statement, other than as expressly stated herein with respect to the issue of the Shares. Our

opinion is limited to the matters stated herein and no opinion is implied or may be inferred beyond the

matters expressly stated. Our opinion herein is expressed solely with respect to the federal laws of the

United States and the General Corporation Law of the State of Delaware. Our opinion is based on these

laws as in effect on the date hereof, and we disclaim any obligation to advise you of facts, circumstances,

events or developments which hereafter may be brought to our attention and which may alter, affect or

modify the opinion expressed herein. We are not rendering any opinion as to compliance with any federal

or state antifraud law, rule or regulation relating to securities, or to the sale or issuance thereof.

Based upon and subject to the foregoing, we advise you that, in our opinion, when the Shares have been

issued and sold by the Company pursuant to the applicable provisions of the Plan and pursuant to the

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agreements which accompany the Plan, and in accordance with the Registration Statement, such Shares

will be validly issued, fully paid and nonassessable.

We hereby consent to the filing of this opinion as an exhibit to the Registration Statement. In giving such

consent, we do not thereby admit that we are in the category of persons whose consent is required under

Section 7 of the Act or the rules and regulations of the Commission thereunder.

Sincerely,

/s/ Gunderson Dettmer Stough
Villeneuve Franklin & Hachigian, LLP

GUNDERSON DETTMER STOUGH

VILLENEUVE FRANKLIN & HACHIGIAN, LLP

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