Consolidated Statements of Cash Flows - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2024	Dec. 31, 2023	Dec. 31, 2022
Operating activities:
Net loss	$ (190,426)	$ (434,801)	$ (547,799)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization	30,968	24,097	16,702
Expensed in-process research and development		2,679	9,290
Non-cash lease expense	15,325	14,519	13,770
Stock-based compensation	274,428	191,808	152,384
Amortization of premiums and accretion of purchase discounts on investment securities	(618)	1,087	4,837
Loss on investments			906
Foreign exchange adjustment	462	265	(2)
Amortization of debt discount and issuance cost	991	1,292	1,259
Non-cash interest expense	2,835	52	302
Non-cash expense recovery	(442)
Changes in operating assets and liabilities:
Accounts receivable	(35,876)	(33,904)	(122,311)
Inventory	(3,985)	(5,353)	(8,497)
Operating lease right-of-use assets		8,354	622
Prepaid expenses and other assets	10,807	(26,072)	(1,202)
Accounts payable	13,210	(15,458)	5,462
Accrued compensation	40,328	21,619	3,069
Operating lease liabilities	(16,819)	(12,448)	(9,999)
Other accrued liabilities	(6,376)	10,347	47,650
Deferred revenue	852	4,962	2,056
Net cash provided by (used in) operating activities	135,664	(246,955)	(431,501)
Investing activities:
Purchases of investments	(122,010)	(98,303)	(86,947)
Proceeds from sale of investments	24,822		248,482
Proceeds from maturity of investments	314,400	306,000	216,500
Purchases of property and equipment	(66,423)	(39,199)	(47,697)
Investment in related party	(2,670)
Cash paid for acquisition of intangible assets	(10,495)
Net cash provided by investing activities	137,624	168,498	330,338
Financing activities:
Proceeds from exercise of stock options	12,988	3,892	6,411
Proceeds from the issuance of common stock under the employee stock purchase plan	17,298	15,128	13,037
Proceeds from public offering, net of issuance cost		235,441	433,192
Proceeds from Credit Line			30,000
Cash redemption on Convertible Note	(82)
Net cash provided by financing activities	30,204	254,461	482,640
Net change in cash, cash equivalents and restricted cash	303,492	176,004	381,477
Beginning cash, cash equivalents and restricted cash	642,095	466,091	84,614
Ending cash, cash equivalents and restricted cash	945,587	642,095	466,091
Supplemental disclosure of cash flow information:
Cash paid for income taxes	1,307	295	549
Cash paid for interest	7,897	11,346	8,060
Non-cash activities:
Purchases of property and equipment in accounts payable and accruals	9,374	1,582	$ (1,940)
Acquisition of warrants	9,424
Amounts accrued for acquisition of intangible assets	1,400
Issuance of common stock for IPR&D milestone		14,435
Issuance of common stock for bonuses	24,071	19,774
Stock-based compensation included in capitalized software development costs	2,263	$ 629
Debt and interest converted into equity	$ 286,730