Leases (Details) $ in Thousands	12 Months Ended
	Dec. 31, 2024 USD ($) ft² location lease	Dec. 31, 2023 USD ($)	Dec. 31, 2022 USD ($)
Lessee, Lease, Description [Line Items]
Operating lease liabilities, current portion included in other accrued liabilities	$ 10,168	$ 11,621
Operating Lease, Liability, Current, Statement of Financial Position [Extensible List]	Other Accrued Liability, Current	Other Accrued Liability, Current
Operating lease liabilities, long-term portion	$ 96,588	$ 67,025
Operating lease liabilities	106,756	78,646
Noncash activities related to right-of-use assets	$ 38,800	2,100
Weighted average remaining lease term	7 years 9 months 3 days
Weighted average discount rate (as a percent)	7.20%
Lease expense	$ 15,300	14,500	$ 13,800
Operating lease payments	$ 16,800	$ 12,400	$ 9,400
Minimum
Lessee, Lease, Description [Line Items]
Term of lease	1 year
Maximum
Lessee, Lease, Description [Line Items]
Term of lease	5 years
Austin TX, Long-term Lease
Lessee, Lease, Description [Line Items]
Lease space (area) | ft²	94,000
Number of office space locations | lease	2
Term of lease	132 months
First Expansion Premises
Lessee, Lease, Description [Line Items]
Lease space (area) | ft²	32,500
Second Expansion Premises
Lessee, Lease, Description [Line Items]
Lease space (area) | ft²	65,222
Corporate Headquarters Lease
Lessee, Lease, Description [Line Items]
Lease space (area) | ft²	136,000
Number of office space locations | location	2
Annual lease payment	$ 9,700
Renewal term of lease	60 months
"First Space" Sublease
Lessee, Lease, Description [Line Items]
Lease space (area) | ft²	88,000
"Second Space" Sublease
Lessee, Lease, Description [Line Items]
Lease space (area) | ft²	48,000
Corporate Headquarters Lease Amendment
Lessee, Lease, Description [Line Items]
Renewal term of lease	48 months
Lease expense	$ 9,300
Tukwila, WA Lease
Lessee, Lease, Description [Line Items]
Lease space (area) | ft²	10,000
Term of lease	62 months
Renewal term of lease	5 years
South San Francisco, CA Lease
Lessee, Lease, Description [Line Items]
Lease space (area) | ft²	11,395
Term of lease	36 months
Renewal term of lease	3 years
Lease expense	$ 900
Pleasanton, CA Lease
Lessee, Lease, Description [Line Items]
Lease space (area) | ft²	16,319
Annual lease payment	$ 500
Term of lease	60 months
Laboratory space in Canada
Lessee, Lease, Description [Line Items]
Lease space (area) | ft²	7,107
Annual lease payment	$ 200
Term of lease	24 months