Consolidated Statements of Operations and Comprehensive Loss - USD ($) shares in Thousands, $ in Thousands	12 Months Ended
	Dec. 31, 2024	Dec. 31, 2023	Dec. 31, 2022
Revenues
Total revenues	$ 1,696,911	$ 1,082,571	$ 820,222
Cost and expenses
Research and development	404,138	320,678	316,415
Selling, general and administrative	841,314	618,307	588,591
Total cost and expenses	1,919,205	1,528,816	1,361,262
Loss from operations	(222,294)	(446,245)	(541,040)
Interest expense	(10,685)	(12,638)	(9,319)
Interest and other income, net	43,248	24,353	3,538
Loss before income taxes	(189,731)	(434,530)	(546,821)
Income tax expense	(695)	(271)	(978)
Net loss	(190,426)	(434,801)	(547,799)
Unrealized gain (loss) on available-for-sale securities, net of tax	2,741	13,277	(14,075)
Comprehensive loss	$ (187,685)	$ (421,524)	$ (561,874)
Net loss per share (Note 13):
Basic (in dollars per share)	$ (1.53)	$ (3.78)	$ (5.57)
Diluted (in dollars per share)	$ (1.53)	$ (3.78)	$ (5.57)
Weighted-average number of shares used in computing basic and diluted net loss per share:
Basic (in shares)	124,718	114,997	98,408
Diluted (in shares)	124,718	114,997	98,408
Product
Revenues
Total revenues	$ 1,685,074	$ 1,068,522	$ 797,307
Cost and expenses
Cost of revenues	672,304	588,564	453,632
Licensing and other
Revenues
Total revenues	11,837	14,049	22,915
Cost and expenses
Cost of revenues	$ 1,449	$ 1,267	$ 2,624