Consolidated Statements of Cash Flows - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2023	Dec. 31, 2022	Dec. 31, 2021
Operating activities:
Net loss	$ (434,801)	$ (547,799)	$ (471,716)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization	24,097	16,702	11,254
Expensed in-process research and development	2,679	9,290	35,604
Non-cash lease expense	14,519	13,770	10,926
Stock-based compensation	191,808	152,384	115,219
Premium amortization and discount accretion on investment securities	1,087	4,837	7,814
(Gain) loss on investments		906	(46)
Foreign exchange adjustment	265	(2)	(11)
Amortization of debt discount and issuance cost	1,292	1,259	1,227
Non-cash interest expense	52	302	94
Changes in operating assets and liabilities:
Accounts receivable	(33,904)	(122,311)	(43,509)
Inventory	(5,353)	(8,497)	(6,878)
Operating lease right-of-use assets	8,354	622
Prepaid expenses and other assets	(26,072)	(1,202)	(3,182)
Accounts payable	(15,458)	5,462	19,222
Accrued compensation	21,619	3,069	10,569
Operating lease liabilities	(12,448)	(9,999)	(10,296)
Other accrued liabilities	10,347	47,650	32,682
Deferred revenue	4,962	2,056	(44,209)
Net cash used in operating activities	(246,955)	(431,501)	(335,236)
Investing activities:
Purchases of investments	(98,303)	(86,947)	(876,095)
Proceeds from sale of investments		248,482	187,580
Proceeds from maturity of investments	306,000	216,500	532,910
Purchases of property and equipment, net	(39,199)	(47,697)	(41,030)
Cash paid for acquisition of an asset			(8,558)
Net cash provided by (used in) investing activities	168,498	330,338	(205,193)
Financing activities:
Proceeds from exercise of stock options	3,892	6,411	11,816
Proceeds from issuance of common stock under employee stock purchase plan	15,128	13,037	13,550
Proceeds from public offering, net of issuance cost	235,441	433,192	550,822
Proceeds from Credit Line		30,000
Net cash provided by financing activities	254,461	482,640	576,188
Net change in cash, cash equivalents and restricted cash	176,004	381,477	35,759
Beginning cash, cash equivalents and restricted cash	466,091	84,614	48,855
Ending cash, cash equivalents and restricted cash	642,095	466,091	84,614
Supplemental disclosure of cash flow information:
Cash paid for income taxes	295	549	283
Cash paid for interest	11,346	8,060	7,077
Non-cash investing and financing activities:
Purchases of property and equipment in accounts payable and accruals	1,582	$ (1,940)	$ 5,173
Issuance of common stock for IPR&D milestone	14,435
Issuance of common stock for bonuses	19,774
Stock-based compensation included in capitalized software development costs	$ 629