Consolidated Statements of Stockholders' Equity - USD ($) $ in Thousands	Common stock	Additional Paid-in Capital	Accumulated Other Comprehensive Income (Loss)	Accumulated Deficit	Total
Balance at Dec. 31, 2020	$ 9	$ 1,411,286	$ 4,259	$ (929,318)	$ 486,236
Balance (in shares) at Dec. 31, 2020	86,223,000
Issuance of common stock upon exercise of stock options		11,816			11,816
Issuance of common stock upon exercise of stock options (in shares)	1,165,000
Issuance of common stock under employee stock purchase plan		13,550			13,550
Issuance of common stock under employee stock purchase plan (in shares)	186,000
Issuance of common stock for IPR&D		30,601			30,601
Issuance of common stock for IPR&D (in shares)	274,000
Vesting of restricted stock units (in shares)	2,117,000
Stock based compensation		115,219			115,219
Unrealized gain (loss) on available-for sale securities			(6,546)		(6,546)
Cumulative-effect adjustment upon adoption		(82,876)		6,198	(76,678)
Issuance of common stock for public offering, net	$ 1	550,821			550,822
Issuance of common stock for public offering, net (in shares)	5,175,000
Net loss				(471,716)	(471,716)
Balance at Dec. 31, 2021	$ 10	2,050,417	(2,287)	(1,394,836)	653,304
Balance (in shares) at Dec. 31, 2021	95,140,000
Issuance of common stock upon exercise of stock options		6,411			6,411
Issuance of common stock upon exercise of stock options (in shares)	828,000
Issuance of common stock under employee stock purchase plan		13,037			13,037
Issuance of common stock under employee stock purchase plan (in shares)	437,000
Issuance of common stock for IPR&D		9,290			9,290
Issuance of common stock for IPR&D (in shares)	225,000
Vesting of restricted stock units (in shares)	1,480,000
Stock based compensation		152,384			152,384
Unrealized gain (loss) on available-for sale securities			(14,075)		(14,075)
Issuance of common stock for public offering, net	$ 1	433,191			433,192
Issuance of common stock for public offering, net (in shares)	13,145,000
Net loss				(547,799)	(547,799)
Balance at Dec. 31, 2022	$ 11	2,664,730	(16,362)	(1,942,635)	$ 705,744
Balance (in shares) at Dec. 31, 2022	111,255,000				111,255,000
Issuance of common stock upon exercise of stock options		3,892			$ 3,892
Issuance of common stock upon exercise of stock options (in shares)	298,000
Issuance of common stock under employee stock purchase plan		15,128			15,128
Issuance of common stock under employee stock purchase plan (in shares)	392,000
Issuance of common stock for IPR&D	$ 336	14,435			14,435
Vesting of restricted stock units (in shares)	2,401,000
Stock based compensation		192,437			192,437
Issuance of common stock for bonuses		19,774			19,774
Issuance of common stock for bonuses (in shares)	349,000
Unrealized gain (loss) on available-for sale securities			13,277		13,277
Issuance of common stock for public offering, net		235,441			235,441
Issuance of common stock for public offering, net (in shares)	4,550,000
Net loss				(434,801)	(434,801)
Balance at Dec. 31, 2023	$ 11	$ 3,145,837	$ (3,085)	$ (2,377,436)	$ 765,327
Balance (in shares) at Dec. 31, 2023	119,581,000				119,581,000