Consolidated Statements of Operations and Comprehensive Loss - USD ($) shares in Thousands, $ in Thousands	12 Months Ended
	Dec. 31, 2023	Dec. 31, 2022	Dec. 31, 2021
Revenues
Total revenues	$ 1,082,571	$ 820,222	$ 625,486
Cost and expenses
Research and development	320,678	316,415	264,208
Selling, general and administrative	618,307	588,591	511,034
Total cost and expenses	1,528,816	1,361,262	1,093,660
Loss from operations	(446,245)	(541,040)	(468,174)
Interest expense	(12,638)	(9,319)	(8,305)
Interest and other income, net	24,353	3,538	5,381
Loss before income taxes	(434,530)	(546,821)	(471,098)
Income tax expense	(271)	(978)	(618)
Net loss	(434,801)	(547,799)	(471,716)
Unrealized gain (loss) on available-for-sale securities, net of tax	13,277	(14,075)	(6,546)
Comprehensive loss	$ (421,524)	$ (561,874)	$ (478,262)
Net Loss per Share
Basic (in dollars per share)	$ (3.78)	$ (5.57)	$ (5.21)
Diluted (in dollars per share)	$ (3.78)	$ (5.57)	$ (5.21)
Weighted-average number of shares used in computing basic and diluted net loss per share:
Basic (in shares)	114,997	98,408	90,558
Diluted (in shares)	114,997	98,408	90,558
Product
Revenues
Total revenues	$ 1,068,522	$ 797,307	$ 580,080
Cost and expenses
Cost of revenues	588,564	453,632	315,195
Licensing and other
Revenues
Total revenues	14,049	22,915	45,406
Cost and expenses
Cost of revenues	$ 1,267	$ 2,624	$ 3,223