Summary of Significant Accounting Policies - Asset acquisition (Details) - USD ($) $ in Thousands		1 Months Ended			3 Months Ended	12 Months Ended
	Sep. 10, 2021	Mar. 31, 2023	Dec. 31, 2022	Nov. 30, 2022	Mar. 31, 2023	Dec. 31, 2023	Dec. 31, 2022	Dec. 31, 2021
Asset Acquisition [Line Items]
Research and development						$ 320,678	$ 316,415	$ 264,208
In-process research and development acquisition
Asset Acquisition [Line Items]
Asset acquisition, consideration	$ 35,600	$ 15,000	$ 10,000
Issuance of common stock	276,346
Value of common stock issued	$ 30,900			$ 10,000	$ 15,000
Cash consideration	3,900
Net liabilities assumed	200
Acquisition related costs	600
Research and development	35,600
Value of additional shares potentially issuable	$ 35,000
Number of additional shares potentially issuable	269,547