Condensed Consolidated Statements of Cash Flows - USD ($) $ in Thousands	9 Months Ended
	Sep. 30, 2023	Sep. 30, 2022
Operating activities:
Net loss	$ (356,770)	$ (405,226)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization	17,186	12,772
Expensed in-process research and development	2,679
Premium amortization and discount accretion on investment securities	1,929	3,971
Stock-based compensation	142,896	116,398
Non-cash lease expense	11,011	9,989
Amortization of debt discount and issuance cost	966	941
Foreign exchange adjustment	265	(12)
Loss on investments		532
Non-cash interest expense	85	100
Changes in operating assets and liabilities:
Accounts receivable	(10,762)	(114,288)
Inventory	(6,669)	(13,520)
Prepaid expenses and other assets	7,356	486
Accounts payable	(8,951)	8,367
Accrued compensation	15,177	1,285
Operating lease liabilities	(8,424)	(7,207)
Other accrued liabilities	(2,072)	35,422
Deferred revenue	5,268	(384)
Cash used in operating activities	(188,830)	(350,374)
Investing activities:
Purchases of investments		(86,947)
Proceeds from sale of investments		214,738
Proceeds from maturity of investments	173,500	216,500
Purchases of property and equipment, net	(29,667)	(35,870)
Cash provided by investing activities	143,833	308,421
Financing activities:
Proceeds from exercise of stock options	3,501	5,971
Proceeds from issuance of common stock under employee stock purchase plan	8,674	8,496
Proceeds from public offering, net of issuance cost	235,441
Cash provided by financing activities	247,616	14,467
Net change in cash, cash equivalents and restricted cash	202,619	(27,486)
Cash, cash equivalents and restricted cash, beginning of period	466,091	84,614
Cash, cash equivalents and restricted cash, end of period	668,710	57,128
Supplemental disclosure of cash flow information:
Cash paid for interest	6,907	4,008
Non-cash investing and financing activities:
Purchases of property and equipment in accounts payable and accruals	(1,168)	$ 458
Issuance of common stock for IPR&D acquisition	14,435
Issuance of common stock for bonuses	$ 19,771