Condensed Consolidated Statements of Stockholders' Equity - USD ($) shares in Thousands, $ in Thousands	Common stock	Additional Paid-in Capital	Accumulated Other Comprehensive Loss	Accumulated Deficit	Total
Balance at Dec. 31, 2021	$ 10	$ 2,050,417	$ (2,287)	$ (1,394,836)	$ 653,304
Balance (in shares) at Dec. 31, 2021	95,140
Issuance of common stock upon exercise of stock options		5,971			5,971
Issuance of common stock upon exercise of stock options (in shares)	785
Issuance of common stock under employee stock purchase plan		8,496			8,496
Issuance of common stock under employee stock purchase plan (in shares)	285
Vesting of restricted stock units (in shares)	1,090
Stock based compensation		116,398			116,398
Unrealized gain (loss) on available-for sale securities			(17,322)		(17,322)
Net loss				(405,226)	(405,226)
Balance at Sep. 30, 2022	$ 10	2,181,282	(19,609)	(1,800,062)	361,621
Balance (in shares) at Sep. 30, 2022	97,300
Balance at Jun. 30, 2022	$ 10	2,139,551	(16,397)	(1,678,582)	444,582
Balance (in shares) at Jun. 30, 2022	96,903
Issuance of common stock upon exercise of stock options		1,393			1,393
Issuance of common stock upon exercise of stock options (in shares)	84
Vesting of restricted stock units (in shares)	313
Stock based compensation		40,338			40,338
Unrealized gain (loss) on available-for sale securities			(3,212)		(3,212)
Net loss				(121,480)	(121,480)
Balance at Sep. 30, 2022	$ 10	2,181,282	(19,609)	(1,800,062)	361,621
Balance (in shares) at Sep. 30, 2022	97,300
Balance at Dec. 31, 2022	$ 11	2,664,730	(16,362)	(1,942,635)	$ 705,744
Balance (in shares) at Dec. 31, 2022	111,255				111,255
Issuance of common stock upon exercise of stock options		3,501			$ 3,501
Issuance of common stock upon exercise of stock options (in shares)	265
Issuance of common stock under employee stock purchase plan		8,674			8,674
Issuance of common stock under employee stock purchase plan (in shares)	219
Issuance of common stock for IPR&D milestone		14,435			14,435
Issuance of common stock for IPR&D milestone (in shares)	336
Vesting of restricted stock units (in shares)	2,016
Stock based compensation		142,896			142,896
Issuance of common stock for bonuses		19,771			19,771
Issuance of common stock for bonuses (in shares)	349
Unrealized gain (loss) on available-for sale securities			10,966		10,966
Issuance of common stock for public offering, net		235,441			235,441
Issuance of common stock for public offering, net (in shares)	4,550
Net loss				(356,770)	(356,770)
Balance at Sep. 30, 2023	$ 11	3,089,448	(5,396)	(2,299,405)	$ 784,658
Balance (in shares) at Sep. 30, 2023	118,990				118,990
Balance at Jun. 30, 2023	$ 11	2,795,714	(9,203)	(2,190,375)	$ 596,147
Balance (in shares) at Jun. 30, 2023	114,051
Issuance of common stock upon exercise of stock options		562			562
Issuance of common stock upon exercise of stock options (in shares)	48
Vesting of restricted stock units (in shares)	341
Stock based compensation		57,731			57,731
Unrealized gain (loss) on available-for sale securities			3,807		3,807
Issuance of common stock for public offering, net		235,441			235,441
Issuance of common stock for public offering, net (in shares)	4,550
Net loss				(109,030)	(109,030)
Balance at Sep. 30, 2023	$ 11	$ 3,089,448	$ (5,396)	$ (2,299,405)	$ 784,658
Balance (in shares) at Sep. 30, 2023	118,990				118,990